Pharmacokinetic Properties of 99mTc-PSMA: A New Radiopharmaceutical for SPECT Imaging of Prostate Cancer
Prostate-specific membrane antigen (PSMA), which is overexpressed in advanced prostate cancer, is a well-established target for the development of antitumor diagnostic and therapeutic radiopharmaceuticals. The aim of this work is the preclinical study of the pharmacokinetics of a new radiopharmaceut...
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| Veröffentlicht in: | Physics of atomic nuclei 2023-12, Vol.86 (11), p.2513-2518 |
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| creator | Tishchenko, V. K. Vlasova, O. P. Ivannikov, A. I. Dorovatovskiy, S. A. Pankratov, A. A. Morozova, N. B. Fedorova, A. V. Lebedeva, A. A. Kuzenkova, K. A. Stepchenkova, E. D. Khailov, A. M. Shegai, P. V. Ivanov, S. A. Kaprin, A. D. |
| description | Prostate-specific membrane antigen (PSMA), which is overexpressed in advanced prostate cancer, is a well-established target for the development of antitumor diagnostic and therapeutic radiopharmaceuticals. The aim of this work is the preclinical study of the pharmacokinetics of a new radiopharmaceutical
99m
Tc-PSMA. Tumor uptake of
99m
Tc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of
99m
Tc-PSMA throughout the study was observed in the kidneys. Tumor uptake of
99m
Tc-PSMA was higher than in other organs and tissues, except the kidneys |
| doi_str_mv | 10.1134/S1063778823110455 |
| format | Article |
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99m
Tc-PSMA. Tumor uptake of
99m
Tc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of
99m
Tc-PSMA throughout the study was observed in the kidneys. Tumor uptake of
99m
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99m
Tc-PSMA. Tumor uptake of
99m
Tc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of
99m
Tc-PSMA throughout the study was observed in the kidneys. Tumor uptake of
99m
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99m
Tc-PSMA. Tumor uptake of
99m
Tc-PSMA is 1.81–3.91%/g with a maximum uptake of 3.91 ± 0.35%/g at 3 h of post-injection. The highest uptake (up to 140.11%/g) of
99m
Tc-PSMA throughout the study was observed in the kidneys. Tumor uptake of
99m
Tc-PSMA was higher than in other organs and tissues, except the kidneys</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1063778823110455</doi><tpages>6</tpages></addata></record> |
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| subjects | Kidneys Medical Physics and Biophysics Particle and Nuclear Physics Physics Physics and Astronomy Radiochemistry |
| title | Pharmacokinetic Properties of 99mTc-PSMA: A New Radiopharmaceutical for SPECT Imaging of Prostate Cancer |
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