Benign Odontogenic Tumors: Origins, Immunophenotypic Features, and Genetic Alterations
Odontogenic tumors are lesions derived from the epithelial and/or mesenchymal elements of the tooth-forming apparatus and are therefore found within the jaw bone or soft tissue overlying teeth. These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable...
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Veröffentlicht in: | Current oral health reports 2016-06, Vol.3 (2), p.93-101 |
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description | Odontogenic tumors are lesions derived from the epithelial and/or mesenchymal elements of the tooth-forming apparatus and are therefore found within the jaw bone or soft tissue overlying teeth. These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable of aggressive growth and locally invasive behavior with a high rate of recurrence. Benign odontogenic tumors can pose diagnostic challenges because of overlapping histology, a lack of distinct phenotypic and molecular features, and an unclear pathogenesis of the tumors. In this article, we will review the possible origins, immunophenotypic features, and genetic alterations of the common benign odontogenic tumors. |
doi_str_mv | 10.1007/s40496-016-0087-x |
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These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable of aggressive growth and locally invasive behavior with a high rate of recurrence. Benign odontogenic tumors can pose diagnostic challenges because of overlapping histology, a lack of distinct phenotypic and molecular features, and an unclear pathogenesis of the tumors. 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In this article, we will review the possible origins, immunophenotypic features, and genetic alterations of the common benign odontogenic tumors.</description><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cyclin-dependent kinases</subject><subject>Cytokines</subject><subject>Dental enamel</subject><subject>Hypotheses</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Oral Neoplasia (F Alawi and A Le</subject><subject>Section Editors</subject><subject>Topical Collection on Oral Neoplasia</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>2196-3002</issn><issn>2196-3002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1UE1Lw0AQXUTBUvsDvAW8Gp3dTTaJt1psLRR6qV6XNZmNKc1u3E2g_fduiaAXD8N8vfeGeYTcUnigANmjTyApRAw0BORZfLwgE0bDhAOwyz_1NZl5vwcAShOgKZ2Q92c0TW2ibWVNb-vQlNFuaK3zT9HWNXVj_H20btvB2O4Tje1PXUAsUfWDw7BSpopWaLAP0_mhR6f6xhp_Q660Onic_eQpeVu-7Bav8Wa7Wi_mm7hknB7jHMtc8QREWVJdUkx5lSDXH2lZVVTnwKBKCqoANYDiQmuRhidTIRALQauCT8ndqNs5-zWg7-XeDs6Ek5IVnGWpyFgaUHRElc5671DLzjWtcidJQZ4dlKODMojLs4PyGDhs5PiANTW6X-X_Sd-ainRB</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Jiang, Chunmiao</creator><creator>Xu, Qilin</creator><creator>Zhang, Qunzhou</creator><creator>Wang, Steven</creator><creator>Carrasco, Lee R.</creator><creator>Le, Anh D.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20160601</creationdate><title>Benign Odontogenic Tumors: Origins, Immunophenotypic Features, and Genetic Alterations</title><author>Jiang, Chunmiao ; 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These tooth development-associated tumors are generally benign, but several odontogenic tumors are capable of aggressive growth and locally invasive behavior with a high rate of recurrence. Benign odontogenic tumors can pose diagnostic challenges because of overlapping histology, a lack of distinct phenotypic and molecular features, and an unclear pathogenesis of the tumors. In this article, we will review the possible origins, immunophenotypic features, and genetic alterations of the common benign odontogenic tumors.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40496-016-0087-x</doi><tpages>9</tpages></addata></record> |
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subjects | Cell adhesion & migration Cell growth Cyclin-dependent kinases Cytokines Dental enamel Hypotheses Kinases Medicine Medicine & Public Health Oral and Maxillofacial Surgery Oral Neoplasia (F Alawi and A Le Section Editors Topical Collection on Oral Neoplasia Tumor necrosis factor-TNF Tumors |
title | Benign Odontogenic Tumors: Origins, Immunophenotypic Features, and Genetic Alterations |
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