Electrosynthesis of Aryliminophosphoranes in Continuous Flow
A practical electrochemical method for synthesizing aryliminophosphoranes from widely available nitro(hetero)arenes in a continuous‐flow system is presented. The utilization of flow technology offers several advantages to our approach, including the elimination of the need for a supporting electroly...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2024-02, Vol.366 (4), p.955-960 |
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| container_title | Advanced synthesis & catalysis |
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| creator | Costa e Silva, Rodrigo Vega, Clara Regnier, Morgan Capaldo, Luca Wesenberg, Lars Lowe, Grace Thiago de Oliveira, Kleber Noël, Timothy |
| description | A practical electrochemical method for synthesizing aryliminophosphoranes from widely available nitro(hetero)arenes in a continuous‐flow system is presented. The utilization of flow technology offers several advantages to our approach, including the elimination of the need for a supporting electrolyte and enhanced scalability. Our method demonstrates good tolerance towards various functional groups, with electron‐deficient nitroarenes being particularly suitable for this strategy. In addition, we have demonstrated the versatility of aryliminophosphoranes as intermediates in synthesizing anilines, amines, and amides. To further enhance the utility of our approach, we have developed a telescoped method that utilizes a tube‐in‐tube setup for the in‐situ production of isocyanates. |
| doi_str_mv | 10.1002/adsc.202300635 |
| format | Article |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Amides Amines Aniline Aromatic compounds Continuous flow flow electrochemistry Functional groups iminophosphoranes Isocyanates nitroarenes paired electrolysis Synthesis undivided cell |
| title | Electrosynthesis of Aryliminophosphoranes in Continuous Flow |
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