High Thermosensitivity of MDA-MB-231 Cells as a Prerequisite for Thermoradiosensitization of Triple-Negative Breast Cancer in Clinical Practice
This work is dedicated to analysis of the thermal sensitivity and efficiency of thermosensitization to γ-radiation of three cell lines of breast cancer of different molecular subtypes. It has been established that the cells of the studied lines differ in sensitivity to hyperthermia and, as a result,...
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| Veröffentlicht in: | Biology bulletin of the Russian Academy of Sciences 2023-12, Vol.50 (12), p.3293-3300 |
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| container_issue | 12 |
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| container_title | Biology bulletin of the Russian Academy of Sciences |
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| creator | Yakimova, A. O. Kabakov, A. E. |
| description | This work is dedicated to analysis of the thermal sensitivity and efficiency of thermosensitization to γ-radiation of three cell lines of breast cancer of different molecular subtypes. It has been established that the cells of the studied lines differ in sensitivity to hyperthermia and, as a result, in the effectiveness of thermoradiosensitization, which raises the question of finding criteria for assessing the rationale of using hyperthermia in each specific case. It has been shown that the level of heat-responsive expression of the
HSP70
gene and also the level of cell genomic instability can serve as such criteria. It was found that the efficiency of thermoradiosensitization is significantly higher in MDA-MB-231 cells compared to the cells of other lines studied. The data obtained suggest that the use of hyperthermia as a radiotherapy-sensitizing cotreatment may be particularly promising toward triple negative breast cancer. |
| doi_str_mv | 10.1134/S1062359023120245 |
| format | Article |
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HSP70
gene and also the level of cell genomic instability can serve as such criteria. It was found that the efficiency of thermoradiosensitization is significantly higher in MDA-MB-231 cells compared to the cells of other lines studied. The data obtained suggest that the use of hyperthermia as a radiotherapy-sensitizing cotreatment may be particularly promising toward triple negative breast cancer.</description><identifier>ISSN: 1062-3590</identifier><identifier>EISSN: 1608-3059</identifier><identifier>DOI: 10.1134/S1062359023120245</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Breast cancer ; breast neoplasms ; bulls ; Cell Biology ; Ecology ; fever ; genes ; genetic instability ; Genomic instability ; Hsp70 protein ; Hyperthermia ; Life Sciences ; Radiation therapy ; Radiobiological Bases of Radiation Therapy of Tumors ; thermosensitivity ; Tumor cell lines ; Zoology ; γ Radiation</subject><ispartof>Biology bulletin of the Russian Academy of Sciences, 2023-12, Vol.50 (12), p.3293-3300</ispartof><rights>Pleiades Publishing, Inc. 2023. ISSN 1062-3590, Biology Bulletin, 2023, Vol. 50, No. 12, pp. 3293–3300. © Pleiades Publishing, Inc., 2023. Russian Text © The Author(s), 2023, published in Radiatsionnaya Biologiya. Radioekologiya, 2023, Vol. 63, No. 1, pp. 71–79.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c301t-9866c064aa6b781252cb42ca5cf6b8d377b462282ff058d92c9f06cc1d22106d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1062359023120245$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1062359023120245$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Yakimova, A. O.</creatorcontrib><creatorcontrib>Kabakov, A. E.</creatorcontrib><title>High Thermosensitivity of MDA-MB-231 Cells as a Prerequisite for Thermoradiosensitization of Triple-Negative Breast Cancer in Clinical Practice</title><title>Biology bulletin of the Russian Academy of Sciences</title><addtitle>Biol Bull Russ Acad Sci</addtitle><description>This work is dedicated to analysis of the thermal sensitivity and efficiency of thermosensitization to γ-radiation of three cell lines of breast cancer of different molecular subtypes. It has been established that the cells of the studied lines differ in sensitivity to hyperthermia and, as a result, in the effectiveness of thermoradiosensitization, which raises the question of finding criteria for assessing the rationale of using hyperthermia in each specific case. It has been shown that the level of heat-responsive expression of the
HSP70
gene and also the level of cell genomic instability can serve as such criteria. It was found that the efficiency of thermoradiosensitization is significantly higher in MDA-MB-231 cells compared to the cells of other lines studied. The data obtained suggest that the use of hyperthermia as a radiotherapy-sensitizing cotreatment may be particularly promising toward triple negative breast cancer.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Breast cancer</subject><subject>breast neoplasms</subject><subject>bulls</subject><subject>Cell Biology</subject><subject>Ecology</subject><subject>fever</subject><subject>genes</subject><subject>genetic instability</subject><subject>Genomic instability</subject><subject>Hsp70 protein</subject><subject>Hyperthermia</subject><subject>Life Sciences</subject><subject>Radiation therapy</subject><subject>Radiobiological Bases of Radiation Therapy of Tumors</subject><subject>thermosensitivity</subject><subject>Tumor cell lines</subject><subject>Zoology</subject><subject>γ Radiation</subject><issn>1062-3590</issn><issn>1608-3059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kd9KwzAUh4soOKcP4F3AG2-qyUmTtZdb_TNhU8F5XbL0dMvo2i1pB_MlfGUzNhEUIZCQ8_0-TnKC4JLRG8Z4dPvGqAQuEgqcAYVIHAUdJmkcciqSY3_25XBXPw3OnFtQSiMeQSf4HJrZnEzmaJe1w8qZxmxMsyV1QcZ3_XA8CL2QpFiWjii_yKtFi-vWeBJJUdtD1qrcfAs-VGPqaqeYWLMqMXzGmb_aIBlYVK4hqao0WmIqkpamMlqVXqt0YzSeByeFKh1eHPZu8P5wP0mH4ejl8Sntj0LNKWvCJJZSUxkpJae9mIEAPY1AK6ELOY1z3utNIwkQQ1FQEecJ6KSgUmuWA_ivyHk3uN57V7Zet-iabGmc9s9UFdatyzgT3AuElB69-oUu6tZWvrsMEs56ggNLPMX2lLa1cxaLbGXNUtltxmi2G1H2Z0Q-A_uM82w1Q_tj_j_0BX4lkkY</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Yakimova, A. O.</creator><creator>Kabakov, A. E.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20231201</creationdate><title>High Thermosensitivity of MDA-MB-231 Cells as a Prerequisite for Thermoradiosensitization of Triple-Negative Breast Cancer in Clinical Practice</title><author>Yakimova, A. O. ; Kabakov, A. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-9866c064aa6b781252cb42ca5cf6b8d377b462282ff058d92c9f06cc1d22106d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Breast cancer</topic><topic>breast neoplasms</topic><topic>bulls</topic><topic>Cell Biology</topic><topic>Ecology</topic><topic>fever</topic><topic>genes</topic><topic>genetic instability</topic><topic>Genomic instability</topic><topic>Hsp70 protein</topic><topic>Hyperthermia</topic><topic>Life Sciences</topic><topic>Radiation therapy</topic><topic>Radiobiological Bases of Radiation Therapy of Tumors</topic><topic>thermosensitivity</topic><topic>Tumor cell lines</topic><topic>Zoology</topic><topic>γ Radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yakimova, A. O.</creatorcontrib><creatorcontrib>Kabakov, A. E.</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yakimova, A. O.</au><au>Kabakov, A. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Thermosensitivity of MDA-MB-231 Cells as a Prerequisite for Thermoradiosensitization of Triple-Negative Breast Cancer in Clinical Practice</atitle><jtitle>Biology bulletin of the Russian Academy of Sciences</jtitle><stitle>Biol Bull Russ Acad Sci</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>50</volume><issue>12</issue><spage>3293</spage><epage>3300</epage><pages>3293-3300</pages><issn>1062-3590</issn><eissn>1608-3059</eissn><abstract>This work is dedicated to analysis of the thermal sensitivity and efficiency of thermosensitization to γ-radiation of three cell lines of breast cancer of different molecular subtypes. It has been established that the cells of the studied lines differ in sensitivity to hyperthermia and, as a result, in the effectiveness of thermoradiosensitization, which raises the question of finding criteria for assessing the rationale of using hyperthermia in each specific case. It has been shown that the level of heat-responsive expression of the
HSP70
gene and also the level of cell genomic instability can serve as such criteria. It was found that the efficiency of thermoradiosensitization is significantly higher in MDA-MB-231 cells compared to the cells of other lines studied. The data obtained suggest that the use of hyperthermia as a radiotherapy-sensitizing cotreatment may be particularly promising toward triple negative breast cancer.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1062359023120245</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biology bulletin of the Russian Academy of Sciences, 2023-12, Vol.50 (12), p.3293-3300 |
| issn | 1062-3590 1608-3059 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biochemistry Biomedical and Life Sciences Breast cancer breast neoplasms bulls Cell Biology Ecology fever genes genetic instability Genomic instability Hsp70 protein Hyperthermia Life Sciences Radiation therapy Radiobiological Bases of Radiation Therapy of Tumors thermosensitivity Tumor cell lines Zoology γ Radiation |
| title | High Thermosensitivity of MDA-MB-231 Cells as a Prerequisite for Thermoradiosensitization of Triple-Negative Breast Cancer in Clinical Practice |
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