Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis
The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis tha...
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creator | Gómez, Natalia Fernanda Pascual Del Pilar Sanz Martín, María Chong, María Auxiliadora Semiglia Cruz, Nelly Daniela Zurita Hernández, Rosa Méndez Molina, Iñigo Guerra Sanz, Iñigo García Tejerina, Angels Figuerola Rueda, Fernando Ramasco |
description | The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures. Statistically significant positive differences were observed in the mean value of the PCT between the group that obtained positive cultures and the group that did not (
< 0.0001). The AUC-ROC of PCT values as a guide to the causal bacteria type was 0.68 (95%CI: 0.57-0.78,
< 0.0021). The PCT value that showed the best diagnostic characteristics for identifying Gram-negative rods (GNR) as the causative agent in blood cultures was 2.1 ng/mL. The positive predictive value (PPV) was 78, 9% (66.3-88.1%). The AUC-ROC of the PCT values for sepsis diagnosis, with any positive culture that could be assessed, was 0.67 (95%CI: 0.63-0.73,
< 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL. |
doi_str_mv | 10.3390/jpm14020208 |
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< 0.0001). The AUC-ROC of PCT values as a guide to the causal bacteria type was 0.68 (95%CI: 0.57-0.78,
< 0.0021). The PCT value that showed the best diagnostic characteristics for identifying Gram-negative rods (GNR) as the causative agent in blood cultures was 2.1 ng/mL. The positive predictive value (PPV) was 78, 9% (66.3-88.1%). The AUC-ROC of the PCT values for sepsis diagnosis, with any positive culture that could be assessed, was 0.67 (95%CI: 0.63-0.73,
< 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm14020208</identifier><identifier>PMID: 38392641</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bacteria ; Biomarkers ; Blood ; Blood tests ; Health aspects ; Hospitals ; Infection ; Laboratories ; Medical examination ; Medical research ; Medicine, Experimental ; Microbiology ; Patients ; Procalcitonin ; Sepsis ; Septic shock ; Statistical analysis</subject><ispartof>Journal of personalized medicine, 2024-02, Vol.14 (2), p.208</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-664480fc76f8818eb4e2c6a66ba9f3f7695fb4e75126dcf5fa47e797741533213</citedby><cites>FETCH-LOGICAL-c388t-664480fc76f8818eb4e2c6a66ba9f3f7695fb4e75126dcf5fa47e797741533213</cites><orcidid>0000-0003-3045-4890 ; 0000-0002-7564-1668 ; 0000-0003-2178-5348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38392641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez, Natalia Fernanda Pascual</creatorcontrib><creatorcontrib>Del Pilar Sanz Martín, María</creatorcontrib><creatorcontrib>Chong, María Auxiliadora Semiglia</creatorcontrib><creatorcontrib>Cruz, Nelly Daniela Zurita</creatorcontrib><creatorcontrib>Hernández, Rosa Méndez</creatorcontrib><creatorcontrib>Molina, Iñigo Guerra</creatorcontrib><creatorcontrib>Sanz, Iñigo García</creatorcontrib><creatorcontrib>Tejerina, Angels Figuerola</creatorcontrib><creatorcontrib>Rueda, Fernando Ramasco</creatorcontrib><title>Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures. Statistically significant positive differences were observed in the mean value of the PCT between the group that obtained positive cultures and the group that did not (
< 0.0001). The AUC-ROC of PCT values as a guide to the causal bacteria type was 0.68 (95%CI: 0.57-0.78,
< 0.0021). The PCT value that showed the best diagnostic characteristics for identifying Gram-negative rods (GNR) as the causative agent in blood cultures was 2.1 ng/mL. The positive predictive value (PPV) was 78, 9% (66.3-88.1%). The AUC-ROC of the PCT values for sepsis diagnosis, with any positive culture that could be assessed, was 0.67 (95%CI: 0.63-0.73,
< 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL.</description><subject>Bacteria</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Blood tests</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Infection</subject><subject>Laboratories</subject><subject>Medical examination</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Microbiology</subject><subject>Patients</subject><subject>Procalcitonin</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Statistical analysis</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkc9LXDEQx0NRqqin3kugR9ltfr0k7yjSqrCiYD0_stnJOst7yTbJWvrfN6K1Fpw5zGTy-SYhX0I-cTaXsmdfN9uJKyZa2g_kUDDTzZQSeu9Nf0BOStmwFrYTQrOP5EBa2Qut-CHB-wJhN0YohaZAb3PybvRYU8RIF_AIY6Eh5bYBK_QV45rWB6DX6HNaYhrTGpuA3mSEWF3FFGkT3raurQv9hfWB3sG2YDkm-8GNBU5e6hG5__7tx_nlbHFzcXV-tph5aW2daa2UZcEbHazlFpYKhNdO66XrgwxG911oM9NxoVc-dMEpA6Y3RvFOSsHlEfnyfO42p587KHXYpF2O7cpB9JL1nWBS_aPWboQBY0g1Oz9h8cOZsYoprrVu1PwdquUKJvQpQsA2_09w-ixo31NKhjBsM04u_x44G54MG94Y1ujPL0_dLSdYvbJ_7ZF_AMHoj2o</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Gómez, Natalia Fernanda Pascual</creator><creator>Del Pilar Sanz Martín, María</creator><creator>Chong, María Auxiliadora Semiglia</creator><creator>Cruz, Nelly Daniela Zurita</creator><creator>Hernández, Rosa Méndez</creator><creator>Molina, Iñigo Guerra</creator><creator>Sanz, Iñigo García</creator><creator>Tejerina, Angels Figuerola</creator><creator>Rueda, Fernando Ramasco</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0003-3045-4890</orcidid><orcidid>https://orcid.org/0000-0002-7564-1668</orcidid><orcidid>https://orcid.org/0000-0003-2178-5348</orcidid></search><sort><creationdate>20240201</creationdate><title>Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis</title><author>Gómez, Natalia Fernanda Pascual ; Del Pilar Sanz Martín, María ; Chong, María Auxiliadora Semiglia ; Cruz, Nelly Daniela Zurita ; Hernández, Rosa Méndez ; Molina, Iñigo Guerra ; Sanz, Iñigo García ; Tejerina, Angels Figuerola ; Rueda, Fernando Ramasco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-664480fc76f8818eb4e2c6a66ba9f3f7695fb4e75126dcf5fa47e797741533213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bacteria</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Blood tests</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Infection</topic><topic>Laboratories</topic><topic>Medical examination</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Microbiology</topic><topic>Patients</topic><topic>Procalcitonin</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez, Natalia Fernanda Pascual</creatorcontrib><creatorcontrib>Del Pilar Sanz Martín, María</creatorcontrib><creatorcontrib>Chong, María Auxiliadora Semiglia</creatorcontrib><creatorcontrib>Cruz, Nelly Daniela Zurita</creatorcontrib><creatorcontrib>Hernández, Rosa Méndez</creatorcontrib><creatorcontrib>Molina, Iñigo Guerra</creatorcontrib><creatorcontrib>Sanz, Iñigo García</creatorcontrib><creatorcontrib>Tejerina, Angels Figuerola</creatorcontrib><creatorcontrib>Rueda, Fernando Ramasco</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez, Natalia Fernanda Pascual</au><au>Del Pilar Sanz Martín, María</au><au>Chong, María Auxiliadora Semiglia</au><au>Cruz, Nelly Daniela Zurita</au><au>Hernández, Rosa Méndez</au><au>Molina, Iñigo Guerra</au><au>Sanz, Iñigo García</au><au>Tejerina, Angels Figuerola</au><au>Rueda, Fernando Ramasco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis</atitle><jtitle>Journal of personalized medicine</jtitle><addtitle>J Pers Med</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>14</volume><issue>2</issue><spage>208</spage><pages>208-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures. Statistically significant positive differences were observed in the mean value of the PCT between the group that obtained positive cultures and the group that did not (
< 0.0001). The AUC-ROC of PCT values as a guide to the causal bacteria type was 0.68 (95%CI: 0.57-0.78,
< 0.0021). The PCT value that showed the best diagnostic characteristics for identifying Gram-negative rods (GNR) as the causative agent in blood cultures was 2.1 ng/mL. The positive predictive value (PPV) was 78, 9% (66.3-88.1%). The AUC-ROC of the PCT values for sepsis diagnosis, with any positive culture that could be assessed, was 0.67 (95%CI: 0.63-0.73,
< 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38392641</pmid><doi>10.3390/jpm14020208</doi><orcidid>https://orcid.org/0000-0003-3045-4890</orcidid><orcidid>https://orcid.org/0000-0002-7564-1668</orcidid><orcidid>https://orcid.org/0000-0003-2178-5348</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Bacteria Biomarkers Blood Blood tests Health aspects Hospitals Infection Laboratories Medical examination Medical research Medicine, Experimental Microbiology Patients Procalcitonin Sepsis Septic shock Statistical analysis |
title | Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis |
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