Ir(tri-N-heterocyclic carbene)-catalyzed upgrading of glycerol: C-C bond formation for the synthesis of α-hydroxy acids
Ir(triNHC) complexes catalyzed glycerol and alcohol dehydrogenative coupling, yielding diverse α-hydroxy acids. Unlike conventional conditions, Ir(triNHC) facilitated additional C-C bond formation after lactic acid production from glycerol, exhibiting high TOFs. This protocol successfully converted...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-02, Vol.22 (8), p.1613-1618 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Byeon, Heemin Kim, Jaeho Lee, Mi-hyun Jang, Hye-Young |
| description | Ir(triNHC) complexes catalyzed glycerol and alcohol dehydrogenative coupling, yielding diverse α-hydroxy acids. Unlike conventional conditions, Ir(triNHC) facilitated additional C-C bond formation after lactic acid production from glycerol, exhibiting high TOFs. This protocol successfully converted 1,2-propanediol and sorbitol into α-hydroxy acids, highlighting biomass-derived sources' potential as valuable platform chemicals.
Unveiling the catalytic excellence of Ir(triNHC) complexes, we pioneered their role in the dehydrogenative coupling of glycerol-sustainable C3 source-and alcohol, resulting in diverse hydroxy acids with high turnover frequencies. |
| doi_str_mv | 10.1039/d3ob02035e |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2024-02, Vol.22 (8), p.1613-1618 |
| issn | 1477-0520 1477-0539 1477-0539 |
| language | eng |
| recordid | cdi_proquest_journals_2928800216 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Acid production Acids Bonding Covalent bonds Dehydrogenation Glycerol Hydroxy acids Lactic acid Sorbitol |
| title | Ir(tri-N-heterocyclic carbene)-catalyzed upgrading of glycerol: C-C bond formation for the synthesis of α-hydroxy acids |
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