CowScape: Quantitative reconstruction of the conformational landscape of biological macromolecules from cryo-EM data

Cryo-EM data processing typically focuses on the structure of the main conformational state under investigation and discards images that belong to other states. This approach can reach atomic resolution, but ignores vast amounts of valuable information about the underlying conformational ensemble an...

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Veröffentlicht in:	arXiv.org 2024-02
Hauptverfasser:	Lambrecht, Felix, Kröpelin, Andreas, Lüttich, Mario, Habeck, Michael, Haselbach, David, Stark, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Data processing Density Image classification Image reconstruction Macromolecules Principal components analysis Variability
Online-Zugang:	Volltext
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