Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion
The nature and associations of gallbladder (GB) "adenomyoma" (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs. To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM. Cholecystectomy cohorts analyzed were 19...
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| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2024-02, Vol.148 (2), p.206-214 |
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| creator | Dursun, Nevra Memis, Bahar Pehlivanoglu, Burcin Taskin, Orhun Cig Okcu, Oguzhan Akkas, Gizem Bagci, Pelin Balci, Serdar Saka, Burcu Araya, Juan Carlos Bellolio, Enrique Roa, Juan Carlos Jang, Kee-Taek Losada, Hector Maithel, Shishir K Sarmiento, Juan Reid, Michelle D Jang, Jin-Young Cheng, Jeanette D Basturk, Olca Koshiol, Jill Adsay, N Volkan |
| description | The nature and associations of gallbladder (GB) "adenomyoma" (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs.
To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM.
Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM.
Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio = 1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ("adenomyomatosis"). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM).
AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name "adeno-myoma" is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flat-type high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found. |
| doi_str_mv | 10.5858/arpa.2022-0379-OA |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2928642365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A785207116</galeid><sourcerecordid>A785207116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-e5221193c256ac2407f377bdf60afe88b042c8f5836166143df0f914f297c3523</originalsourceid><addsrcrecordid>eNptkl1r2zAUhsVYWdNuP2A3QzDYVZ3pw_LH7kxou0FGYGzX4kSWYhXZ8iRnkH_Rn1y56bYWggTiSM97xHt4EXpPyVJUovoMYYQlI4xlhJd1tmleoQUVOc8YLcRrtCCE8KyuK3GOLmK8S2XNGH2DznlJec6YWKD7ptWD7w--h4i9wVOn8S04t3XQtjp8wc2QNrhDtI_vN0H_3utBHa7wytnBKj_C1Hnnd1bhJkavLEzWD_EKw9DiH9ody86OePJ4BUHZ9B_MvQB_B2d86BPyR-O1jol8i84MuKjfPZ2X6NfN9c_V12y9uf22ataZyksxZVokJ7TmiokCFMtJaXhZbltTEDC6qrYkZ6oyouIFLQqa89YQU9PcsLpUXDB-iT4e-47BJ0dxknd-H5LTKFnNqiJnvBD_qR04Le1g_BRA9TYq2ZSVYKSktEhUdoLa6UEHcH7QxqbrF_zyBJ9Wq_s00VOCT88EnQY3ddG7_eNoX4L0CKrgYwzayDHYHsJBUiLnzMg5M3LOjJwzIzdN0nx4msR-2-v2n-JvSPgDytm7ow</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2928642365</pqid></control><display><type>article</type><title>Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion</title><source>Allen Press Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Dursun, Nevra ; Memis, Bahar ; Pehlivanoglu, Burcin ; Taskin, Orhun Cig ; Okcu, Oguzhan ; Akkas, Gizem ; Bagci, Pelin ; Balci, Serdar ; Saka, Burcu ; Araya, Juan Carlos ; Bellolio, Enrique ; Roa, Juan Carlos ; Jang, Kee-Taek ; Losada, Hector ; Maithel, Shishir K ; Sarmiento, Juan ; Reid, Michelle D ; Jang, Jin-Young ; Cheng, Jeanette D ; Basturk, Olca ; Koshiol, Jill ; Adsay, N Volkan</creator><creatorcontrib>Dursun, Nevra ; Memis, Bahar ; Pehlivanoglu, Burcin ; Taskin, Orhun Cig ; Okcu, Oguzhan ; Akkas, Gizem ; Bagci, Pelin ; Balci, Serdar ; Saka, Burcu ; Araya, Juan Carlos ; Bellolio, Enrique ; Roa, Juan Carlos ; Jang, Kee-Taek ; Losada, Hector ; Maithel, Shishir K ; Sarmiento, Juan ; Reid, Michelle D ; Jang, Jin-Young ; Cheng, Jeanette D ; Basturk, Olca ; Koshiol, Jill ; Adsay, N Volkan</creatorcontrib><description>The nature and associations of gallbladder (GB) "adenomyoma" (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs.
To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM.
Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM.
Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio = 1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ("adenomyomatosis"). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM).
AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name "adeno-myoma" is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flat-type high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found.</description><identifier>ISSN: 0003-9985</identifier><identifier>ISSN: 1543-2165</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/arpa.2022-0379-OA</identifier><identifier>PMID: 37134225</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Analysis ; Cancer ; Care and treatment ; Cholecystectomy ; Cholecystitis ; Clinical pathology ; Diagnosis ; Females ; Gallbladder ; Gallbladder cancer ; Gallbladder diseases ; Kruskal-Wallis test ; Localization ; Normal distribution ; Patient outcomes ; Statistical analysis ; Tumors ; Variables ; Variance analysis</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2024-02, Vol.148 (2), p.206-214</ispartof><rights>2024 College of American Pathologists.</rights><rights>COPYRIGHT 2024 College of American Pathologists</rights><rights>Copyright College of American Pathologists Feb 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-e5221193c256ac2407f377bdf60afe88b042c8f5836166143df0f914f297c3523</citedby><cites>FETCH-LOGICAL-c475t-e5221193c256ac2407f377bdf60afe88b042c8f5836166143df0f914f297c3523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37134225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dursun, Nevra</creatorcontrib><creatorcontrib>Memis, Bahar</creatorcontrib><creatorcontrib>Pehlivanoglu, Burcin</creatorcontrib><creatorcontrib>Taskin, Orhun Cig</creatorcontrib><creatorcontrib>Okcu, Oguzhan</creatorcontrib><creatorcontrib>Akkas, Gizem</creatorcontrib><creatorcontrib>Bagci, Pelin</creatorcontrib><creatorcontrib>Balci, Serdar</creatorcontrib><creatorcontrib>Saka, Burcu</creatorcontrib><creatorcontrib>Araya, Juan Carlos</creatorcontrib><creatorcontrib>Bellolio, Enrique</creatorcontrib><creatorcontrib>Roa, Juan Carlos</creatorcontrib><creatorcontrib>Jang, Kee-Taek</creatorcontrib><creatorcontrib>Losada, Hector</creatorcontrib><creatorcontrib>Maithel, Shishir K</creatorcontrib><creatorcontrib>Sarmiento, Juan</creatorcontrib><creatorcontrib>Reid, Michelle D</creatorcontrib><creatorcontrib>Jang, Jin-Young</creatorcontrib><creatorcontrib>Cheng, Jeanette D</creatorcontrib><creatorcontrib>Basturk, Olca</creatorcontrib><creatorcontrib>Koshiol, Jill</creatorcontrib><creatorcontrib>Adsay, N Volkan</creatorcontrib><title>Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>The nature and associations of gallbladder (GB) "adenomyoma" (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs.
To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM.
Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM.
Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio = 1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ("adenomyomatosis"). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM).
AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name "adeno-myoma" is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flat-type high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found.</description><subject>Analysis</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cholecystectomy</subject><subject>Cholecystitis</subject><subject>Clinical pathology</subject><subject>Diagnosis</subject><subject>Females</subject><subject>Gallbladder</subject><subject>Gallbladder cancer</subject><subject>Gallbladder diseases</subject><subject>Kruskal-Wallis test</subject><subject>Localization</subject><subject>Normal distribution</subject><subject>Patient outcomes</subject><subject>Statistical analysis</subject><subject>Tumors</subject><subject>Variables</subject><subject>Variance 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Associations, and Relationship to Carcinoma of a Malformative Lesion</title><author>Dursun, Nevra ; Memis, Bahar ; Pehlivanoglu, Burcin ; Taskin, Orhun Cig ; Okcu, Oguzhan ; Akkas, Gizem ; Bagci, Pelin ; Balci, Serdar ; Saka, Burcu ; Araya, Juan Carlos ; Bellolio, Enrique ; Roa, Juan Carlos ; Jang, Kee-Taek ; Losada, Hector ; Maithel, Shishir K ; Sarmiento, Juan ; Reid, Michelle D ; Jang, Jin-Young ; Cheng, Jeanette D ; Basturk, Olca ; Koshiol, Jill ; Adsay, N Volkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-e5221193c256ac2407f377bdf60afe88b042c8f5836166143df0f914f297c3523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cholecystectomy</topic><topic>Cholecystitis</topic><topic>Clinical pathology</topic><topic>Diagnosis</topic><topic>Females</topic><topic>Gallbladder</topic><topic>Gallbladder cancer</topic><topic>Gallbladder diseases</topic><topic>Kruskal-Wallis test</topic><topic>Localization</topic><topic>Normal distribution</topic><topic>Patient outcomes</topic><topic>Statistical analysis</topic><topic>Tumors</topic><topic>Variables</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dursun, Nevra</creatorcontrib><creatorcontrib>Memis, Bahar</creatorcontrib><creatorcontrib>Pehlivanoglu, Burcin</creatorcontrib><creatorcontrib>Taskin, Orhun Cig</creatorcontrib><creatorcontrib>Okcu, Oguzhan</creatorcontrib><creatorcontrib>Akkas, Gizem</creatorcontrib><creatorcontrib>Bagci, Pelin</creatorcontrib><creatorcontrib>Balci, Serdar</creatorcontrib><creatorcontrib>Saka, Burcu</creatorcontrib><creatorcontrib>Araya, Juan Carlos</creatorcontrib><creatorcontrib>Bellolio, 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dursun, Nevra</au><au>Memis, Bahar</au><au>Pehlivanoglu, Burcin</au><au>Taskin, Orhun Cig</au><au>Okcu, Oguzhan</au><au>Akkas, Gizem</au><au>Bagci, Pelin</au><au>Balci, Serdar</au><au>Saka, Burcu</au><au>Araya, Juan Carlos</au><au>Bellolio, Enrique</au><au>Roa, Juan Carlos</au><au>Jang, Kee-Taek</au><au>Losada, Hector</au><au>Maithel, Shishir K</au><au>Sarmiento, Juan</au><au>Reid, Michelle D</au><au>Jang, Jin-Young</au><au>Cheng, Jeanette D</au><au>Basturk, Olca</au><au>Koshiol, Jill</au><au>Adsay, N Volkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>148</volume><issue>2</issue><spage>206</spage><epage>214</epage><pages>206-214</pages><issn>0003-9985</issn><issn>1543-2165</issn><eissn>1543-2165</eissn><abstract>The nature and associations of gallbladder (GB) "adenomyoma" (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs.
To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM.
Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM.
Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio = 1.9 (177:94) and mean size = 1.3 cm (range, 0.3-5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive ("adenomyomatosis"). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma arose from AM (invasion was confined to AM, and dysplasia was predominantly in AM).
AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component (ie, the name "adeno-myoma" is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, flat-type high-grade dysplasia or carcinoma in situ, and invasive carcinoma (1.8%, 5 of 283). It is recommended that gross examination of GBs include serial slicing of the fundus for AM detection and total submission if one is found.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>37134225</pmid><doi>10.5858/arpa.2022-0379-OA</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9985 |
| ispartof | Archives of pathology & laboratory medicine (1976), 2024-02, Vol.148 (2), p.206-214 |
| issn | 0003-9985 1543-2165 1543-2165 |
| language | eng |
| recordid | cdi_proquest_journals_2928642365 |
| source | Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Analysis Cancer Care and treatment Cholecystectomy Cholecystitis Clinical pathology Diagnosis Females Gallbladder Gallbladder cancer Gallbladder diseases Kruskal-Wallis test Localization Normal distribution Patient outcomes Statistical analysis Tumors Variables Variance analysis |
| title | Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-08T07%3A16%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adenomyomas%20of%20the%20Gallbladder:%20An%20Analysis%20of%20Frequency,%20Clinicopathologic%20Associations,%20and%20Relationship%20to%20Carcinoma%20of%20a%20Malformative%20Lesion&rft.jtitle=Archives%20of%20pathology%20&%20laboratory%20medicine%20(1976)&rft.au=Dursun,%20Nevra&rft.date=2024-02-01&rft.volume=148&rft.issue=2&rft.spage=206&rft.epage=214&rft.pages=206-214&rft.issn=0003-9985&rft.eissn=1543-2165&rft_id=info:doi/10.5858/arpa.2022-0379-OA&rft_dat=%3Cgale_proqu%3EA785207116%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2928642365&rft_id=info:pmid/37134225&rft_galeid=A785207116&rfr_iscdi=true |