The physiological role of phytosomal curcumin to mitigate hemolytic anemia and cytogenic effect induced by phenylhydrazine in rats

We investigates the physiological efficacy of encapsulated curcumin in the treatment of adult Albino Wistar rats with phenylhydrazine (PHZ)-induced hemolytic anemia. Thirty adult male rats were employed in this investigation, and randomly parted into five groups. One was used as a negative control group (NCG) and fed on chow and water. Animals in the T1 group received an i.p PHZ (40mg/kg B.W) for two days; those in the T2 group received PHZ (40 mg/kg) and oral curcumin at 50 mg/kg daily for four weeks; and those in the T3 and T4 groups received PHZ (40 mg/kg) and phytosome-loaded curcumin at 25 & 50 mg/Kg daily for four weeks, respectively. All of the animals were sacrificed as the experimentation done. Haematological parameters were done for additional biochemical analyses. Analyses of cytogenic activity and hematological parameters were assessed. The current study shows that loaded curcumin on phytosomes with a sufficient polydisperssin index maintains the stability of phytosomes and exhibits a strong ability to attenuate anemic effects that were caused by phenyl hydrazine. This might hold out the possibility of developing a fresh approach to treating various forms of pathological and physiological anemia. Ultimately, we discovered that phytosom was easily loaded and enclosed within an appropriate size and shape. By enhancing hematological parameters in addition to its physiological role in reducing the genotoxic effect of phenylhyrazine, curcumin and its liposome are regarded as an effective treatment for anemia in rats.