Improved matrix purification using a graphene oxide-coated melamine sponge for UPLC-MS/MS-based determination of 37 veterinary drugs in milks
A rapid and highly sensitive method was established for the analysis of 37 veterinary drug residues in milk using a modified QuEChERS method based on a reduced graphene oxide-coated melamine sponge (rGO@MeS) coupled with UPLC-MS/MS. Under optimal chromatographic and mass spectrometric conditions, th...
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| Veröffentlicht in: | Analytical methods 2024-02, Vol.16 (6), p.856-863 |
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| creator | Xu, Xu Lv, Jia Zhou, Jintian Ji, Baocheng Yang, Lanrui Xu, Gaigai Hou, Zhuchen Li, Lulu Bai, Yanhong |
| description | A rapid and highly sensitive method was established for the analysis of 37 veterinary drug residues in milk using a modified QuEChERS method based on a reduced graphene oxide-coated melamine sponge (rGO@MeS) coupled with UPLC-MS/MS. Under optimal chromatographic and mass spectrometric conditions, the effects of different dehydrated salts (MgSO
4
and Na
2
SO
4
) and metal chelating agents (Na
2
EDTA) on extraction efficiency were first investigated. Next, the influence of a dynamic and static purification mode was evaluated in terms of drug recoveries. Calibration curves of 37 veterinary drugs were constructed in the range 0.6-500 μg kg
−1
, and good linearities were obtained with all determination coefficients (
R
2
) ≥0.992. The limits of detection (LODs) and quantitation (LOQs) were in the range 0.3-1.1 μg kg
−1
and 0.6-3.5 μg kg
−1
, respectively. The recoveries of all compounds were in the range 61.3-118.2% at three spiked levels (20, 100, and 200 μg kg
−1
) with RSDs ≤15.4% for both intra- and inter-day precisions. Compared to pristine melamine sponges and commercial adsorbents (C18, PSA, and GCB), rGO@MeS demonstrated an equal or even better purification performance in terms of recoveries, matrix effects, and matrix removal efficiency. This method is rapid, simple, efficient, and appropriate for the qualitative and quantitative analyses of 37 veterinary drug residues in milk, providing a new detection strategy and technical support for the routine analysis of animal-derived food.
A fast and convenient matrix purification method based on a reduced graphene oxide coated melamine sponge was developed for the analysis of 37 veterinary drugs in milks using UPLC-MS/MS. |
| doi_str_mv | 10.1039/d3ay01797d |
| format | Article |
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4
and Na
2
SO
4
) and metal chelating agents (Na
2
EDTA) on extraction efficiency were first investigated. Next, the influence of a dynamic and static purification mode was evaluated in terms of drug recoveries. Calibration curves of 37 veterinary drugs were constructed in the range 0.6-500 μg kg
−1
, and good linearities were obtained with all determination coefficients (
R
2
) ≥0.992. The limits of detection (LODs) and quantitation (LOQs) were in the range 0.3-1.1 μg kg
−1
and 0.6-3.5 μg kg
−1
, respectively. The recoveries of all compounds were in the range 61.3-118.2% at three spiked levels (20, 100, and 200 μg kg
−1
) with RSDs ≤15.4% for both intra- and inter-day precisions. Compared to pristine melamine sponges and commercial adsorbents (C18, PSA, and GCB), rGO@MeS demonstrated an equal or even better purification performance in terms of recoveries, matrix effects, and matrix removal efficiency. This method is rapid, simple, efficient, and appropriate for the qualitative and quantitative analyses of 37 veterinary drug residues in milk, providing a new detection strategy and technical support for the routine analysis of animal-derived food.
A fast and convenient matrix purification method based on a reduced graphene oxide coated melamine sponge was developed for the analysis of 37 veterinary drugs in milks using UPLC-MS/MS.</description><identifier>ISSN: 1759-9660</identifier><identifier>EISSN: 1759-9679</identifier><identifier>DOI: 10.1039/d3ay01797d</identifier><identifier>PMID: 38240139</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animal-based foods ; Chelating agents ; Chelation ; Dehydration ; Drugs ; Graphene ; Melamine ; Purification ; Qualitative analysis ; Residues ; Sodium sulfate ; Spectrometry ; Technical services ; Veterinary medicine</subject><ispartof>Analytical methods, 2024-02, Vol.16 (6), p.856-863</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-70009765a59571ab46b42e0b18cf955953eae5d0d4f024b707aa4b3395c1eb9d3</cites><orcidid>0000-0002-2074-0351</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38240139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xu</creatorcontrib><creatorcontrib>Lv, Jia</creatorcontrib><creatorcontrib>Zhou, Jintian</creatorcontrib><creatorcontrib>Ji, Baocheng</creatorcontrib><creatorcontrib>Yang, Lanrui</creatorcontrib><creatorcontrib>Xu, Gaigai</creatorcontrib><creatorcontrib>Hou, Zhuchen</creatorcontrib><creatorcontrib>Li, Lulu</creatorcontrib><creatorcontrib>Bai, Yanhong</creatorcontrib><title>Improved matrix purification using a graphene oxide-coated melamine sponge for UPLC-MS/MS-based determination of 37 veterinary drugs in milks</title><title>Analytical methods</title><addtitle>Anal Methods</addtitle><description>A rapid and highly sensitive method was established for the analysis of 37 veterinary drug residues in milk using a modified QuEChERS method based on a reduced graphene oxide-coated melamine sponge (rGO@MeS) coupled with UPLC-MS/MS. Under optimal chromatographic and mass spectrometric conditions, the effects of different dehydrated salts (MgSO
4
and Na
2
SO
4
) and metal chelating agents (Na
2
EDTA) on extraction efficiency were first investigated. Next, the influence of a dynamic and static purification mode was evaluated in terms of drug recoveries. Calibration curves of 37 veterinary drugs were constructed in the range 0.6-500 μg kg
−1
, and good linearities were obtained with all determination coefficients (
R
2
) ≥0.992. The limits of detection (LODs) and quantitation (LOQs) were in the range 0.3-1.1 μg kg
−1
and 0.6-3.5 μg kg
−1
, respectively. The recoveries of all compounds were in the range 61.3-118.2% at three spiked levels (20, 100, and 200 μg kg
−1
) with RSDs ≤15.4% for both intra- and inter-day precisions. Compared to pristine melamine sponges and commercial adsorbents (C18, PSA, and GCB), rGO@MeS demonstrated an equal or even better purification performance in terms of recoveries, matrix effects, and matrix removal efficiency. This method is rapid, simple, efficient, and appropriate for the qualitative and quantitative analyses of 37 veterinary drug residues in milk, providing a new detection strategy and technical support for the routine analysis of animal-derived food.
A fast and convenient matrix purification method based on a reduced graphene oxide coated melamine sponge was developed for the analysis of 37 veterinary drugs in milks using UPLC-MS/MS.</description><subject>Animal-based foods</subject><subject>Chelating agents</subject><subject>Chelation</subject><subject>Dehydration</subject><subject>Drugs</subject><subject>Graphene</subject><subject>Melamine</subject><subject>Purification</subject><subject>Qualitative analysis</subject><subject>Residues</subject><subject>Sodium sulfate</subject><subject>Spectrometry</subject><subject>Technical services</subject><subject>Veterinary medicine</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpd0U1LwzAYB_AgivPt4l0JeBGhmjRNsxxlvsJEQXfwVNLm6cxsm5q0oh_C72zm5gRPCf_88pDwR2ifklNKmDzTTH0SKqTQa2iLCi4jmQq5vtqnZIC2vZ8RkkqW0k00YMM4IZTJLfR1W7fOvoPGteqc-cBt70xpCtUZ2-Dem2aKFZ461b5AA9h-GA1RYVU3vwGVqk1IfWubKeDSOjx5GI-iu8ezu8coVz4gDR24oBYDbYmZwO_zLETuE2vXTz02Da5N9ep30UapKg97y3UHTa4un0Y30fj--nZ0Po6KWKZdJAghUqRccckFVXmS5kkMJKfDopQ8hAwUcE10UpI4yQURSiU5Y5IXFHKp2Q46XswNf3_rwXdZbXwBVaUasL3PYhkzSankNNCjf3Rme9eE1_2oeMgYj4M6WajCWe8dlFnrTB0-mFGSzUvKLtj5809JFwEfLkf2eQ16RX9bCeBgAZwvVqd_LbNv0h2W6A</recordid><startdate>20240208</startdate><enddate>20240208</enddate><creator>Xu, Xu</creator><creator>Lv, Jia</creator><creator>Zhou, Jintian</creator><creator>Ji, Baocheng</creator><creator>Yang, Lanrui</creator><creator>Xu, Gaigai</creator><creator>Hou, Zhuchen</creator><creator>Li, Lulu</creator><creator>Bai, Yanhong</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2074-0351</orcidid></search><sort><creationdate>20240208</creationdate><title>Improved matrix purification using a graphene oxide-coated melamine sponge for UPLC-MS/MS-based determination of 37 veterinary drugs in milks</title><author>Xu, Xu ; Lv, Jia ; Zhou, Jintian ; Ji, Baocheng ; Yang, Lanrui ; Xu, Gaigai ; Hou, Zhuchen ; Li, Lulu ; Bai, Yanhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-70009765a59571ab46b42e0b18cf955953eae5d0d4f024b707aa4b3395c1eb9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal-based foods</topic><topic>Chelating agents</topic><topic>Chelation</topic><topic>Dehydration</topic><topic>Drugs</topic><topic>Graphene</topic><topic>Melamine</topic><topic>Purification</topic><topic>Qualitative analysis</topic><topic>Residues</topic><topic>Sodium sulfate</topic><topic>Spectrometry</topic><topic>Technical services</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xu</creatorcontrib><creatorcontrib>Lv, Jia</creatorcontrib><creatorcontrib>Zhou, Jintian</creatorcontrib><creatorcontrib>Ji, Baocheng</creatorcontrib><creatorcontrib>Yang, Lanrui</creatorcontrib><creatorcontrib>Xu, Gaigai</creatorcontrib><creatorcontrib>Hou, Zhuchen</creatorcontrib><creatorcontrib>Li, Lulu</creatorcontrib><creatorcontrib>Bai, Yanhong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xu</au><au>Lv, Jia</au><au>Zhou, Jintian</au><au>Ji, Baocheng</au><au>Yang, Lanrui</au><au>Xu, Gaigai</au><au>Hou, Zhuchen</au><au>Li, Lulu</au><au>Bai, Yanhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved matrix purification using a graphene oxide-coated melamine sponge for UPLC-MS/MS-based determination of 37 veterinary drugs in milks</atitle><jtitle>Analytical methods</jtitle><addtitle>Anal Methods</addtitle><date>2024-02-08</date><risdate>2024</risdate><volume>16</volume><issue>6</issue><spage>856</spage><epage>863</epage><pages>856-863</pages><issn>1759-9660</issn><eissn>1759-9679</eissn><abstract>A rapid and highly sensitive method was established for the analysis of 37 veterinary drug residues in milk using a modified QuEChERS method based on a reduced graphene oxide-coated melamine sponge (rGO@MeS) coupled with UPLC-MS/MS. Under optimal chromatographic and mass spectrometric conditions, the effects of different dehydrated salts (MgSO
4
and Na
2
SO
4
) and metal chelating agents (Na
2
EDTA) on extraction efficiency were first investigated. Next, the influence of a dynamic and static purification mode was evaluated in terms of drug recoveries. Calibration curves of 37 veterinary drugs were constructed in the range 0.6-500 μg kg
−1
, and good linearities were obtained with all determination coefficients (
R
2
) ≥0.992. The limits of detection (LODs) and quantitation (LOQs) were in the range 0.3-1.1 μg kg
−1
and 0.6-3.5 μg kg
−1
, respectively. The recoveries of all compounds were in the range 61.3-118.2% at three spiked levels (20, 100, and 200 μg kg
−1
) with RSDs ≤15.4% for both intra- and inter-day precisions. Compared to pristine melamine sponges and commercial adsorbents (C18, PSA, and GCB), rGO@MeS demonstrated an equal or even better purification performance in terms of recoveries, matrix effects, and matrix removal efficiency. This method is rapid, simple, efficient, and appropriate for the qualitative and quantitative analyses of 37 veterinary drug residues in milk, providing a new detection strategy and technical support for the routine analysis of animal-derived food.
A fast and convenient matrix purification method based on a reduced graphene oxide coated melamine sponge was developed for the analysis of 37 veterinary drugs in milks using UPLC-MS/MS.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38240139</pmid><doi>10.1039/d3ay01797d</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2074-0351</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1759-9660 |
| ispartof | Analytical methods, 2024-02, Vol.16 (6), p.856-863 |
| issn | 1759-9660 1759-9679 |
| language | eng |
| recordid | cdi_proquest_journals_2923283352 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Animal-based foods Chelating agents Chelation Dehydration Drugs Graphene Melamine Purification Qualitative analysis Residues Sodium sulfate Spectrometry Technical services Veterinary medicine |
| title | Improved matrix purification using a graphene oxide-coated melamine sponge for UPLC-MS/MS-based determination of 37 veterinary drugs in milks |
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