High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study
Background: The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown. Objective: We performed a cross-sectional stu...
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| Veröffentlicht in: | The open AIDS journal 2023-01, Vol.17, p.1-9 |
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| container_title | The open AIDS journal |
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| creator | Višković, Klaudija Marinelli, Annibale Nedeljko, Katrin Bržan, Petra Povalej Bogdanić, Nikolina Begovac, Josip |
| description | Background: The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown. Objective: We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group. Methods: MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73m2 and 25 with an eGFR |
| doi_str_mv | 10.2174/18746136-vl6-e221226-2022-11 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2922952796</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2922952796</sourcerecordid><originalsourceid>FETCH-proquest_journals_29229527963</originalsourceid><addsrcrecordid>eNqNjU1LAzEQhoMoWD_-w4Beo5tpm1pvZa1UUCh-1GMJu7M2JSaayVb7n_yRZsWDR0_zMO8z7whxqoozVKPBuboYDbTqa7lxWhKiQtQSC0Sp1I7odbHs8t0_vC8OmNdFoVHrYU98zezLCuaRNsaRrwhCA7fhgyJMP1OkV5u2cEe1NQ4mMVHsoDSuso2tTLLBg_Uwu1lY31CVqIZ53pJPDM82rcD4-gdCm6BcxeBtBffkc8mVZTJMlzCBheGqdSbCk0vRcGjzURkDs-TcmX9k_SG19fZI7DXGMR3_zkNxcj19LGfyLYb3ljgt16GNWecljhHHQxyNdf9_1jeTrWm_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2922952796</pqid></control><display><type>article</type><title>High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Višković, Klaudija ; Marinelli, Annibale ; Nedeljko, Katrin ; Bržan, Petra Povalej ; Bogdanić, Nikolina ; Begovac, Josip</creator><creatorcontrib>Višković, Klaudija ; Marinelli, Annibale ; Nedeljko, Katrin ; Bržan, Petra Povalej ; Bogdanić, Nikolina ; Begovac, Josip</creatorcontrib><description>Background: The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown. Objective: We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group. Methods: MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73m2 and 25 with an eGFR <60 mL/min/ 1.73m2) and 141 HIV-uninfected patients (68 with eGFR<60 ml/min/L73m2). Results: MAC was most frequently found in PLWH with CKD (76%). The prevalence of MAC among PLWH was 54.0% (95% confidence interval [CI], 40.4-67.0%), whereas, in HIV-uninfected, it was 34.0% (95% CI, 26.7-42.2%, P=0.013). Age and CKD were consistently associated with MAC in our multivariable models, and there was also a sign that PLWH had higher odds of having MAC. Conclusion: We found a higher prevalence of MAC in PAD-asymptomatic PLWH compared to HIV-uninfected ones and provided evidence that HIV infection could be associated with MAC.</description><identifier>ISSN: 1874-6136</identifier><identifier>EISSN: 1874-6136</identifier><identifier>DOI: 10.2174/18746136-vl6-e221226-2022-11</identifier><language>eng</language><publisher>Sharjah: Benham Science Publishers</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Asymptomatic ; Atherosclerosis ; Blood pressure ; Body mass index ; Calcification ; Cardiovascular disease ; Coronary vessels ; Cross-sectional studies ; Diabetes ; Hemodialysis ; HIV ; Hospitals ; Human immunodeficiency virus ; Hypertension ; Infections ; Kidney diseases ; Metabolic disorders ; Nephrology ; Regression analysis ; Ultrasonic imaging ; Vein & artery diseases</subject><ispartof>The open AIDS journal, 2023-01, Vol.17, p.1-9</ispartof><rights>Copyright Benham Science Publishers 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Višković, Klaudija</creatorcontrib><creatorcontrib>Marinelli, Annibale</creatorcontrib><creatorcontrib>Nedeljko, Katrin</creatorcontrib><creatorcontrib>Bržan, Petra Povalej</creatorcontrib><creatorcontrib>Bogdanić, Nikolina</creatorcontrib><creatorcontrib>Begovac, Josip</creatorcontrib><title>High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study</title><title>The open AIDS journal</title><description>Background: The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown. Objective: We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group. Methods: MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73m2 and 25 with an eGFR <60 mL/min/ 1.73m2) and 141 HIV-uninfected patients (68 with eGFR<60 ml/min/L73m2). Results: MAC was most frequently found in PLWH with CKD (76%). The prevalence of MAC among PLWH was 54.0% (95% confidence interval [CI], 40.4-67.0%), whereas, in HIV-uninfected, it was 34.0% (95% CI, 26.7-42.2%, P=0.013). Age and CKD were consistently associated with MAC in our multivariable models, and there was also a sign that PLWH had higher odds of having MAC. Conclusion: We found a higher prevalence of MAC in PAD-asymptomatic PLWH compared to HIV-uninfected ones and provided evidence that HIV infection could be associated with MAC.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Antiretroviral drugs</subject><subject>Asymptomatic</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Calcification</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Hemodialysis</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Kidney diseases</subject><subject>Metabolic disorders</subject><subject>Nephrology</subject><subject>Regression analysis</subject><subject>Ultrasonic imaging</subject><subject>Vein & artery diseases</subject><issn>1874-6136</issn><issn>1874-6136</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNjU1LAzEQhoMoWD_-w4Beo5tpm1pvZa1UUCh-1GMJu7M2JSaayVb7n_yRZsWDR0_zMO8z7whxqoozVKPBuboYDbTqa7lxWhKiQtQSC0Sp1I7odbHs8t0_vC8OmNdFoVHrYU98zezLCuaRNsaRrwhCA7fhgyJMP1OkV5u2cEe1NQ4mMVHsoDSuso2tTLLBg_Uwu1lY31CVqIZ53pJPDM82rcD4-gdCm6BcxeBtBffkc8mVZTJMlzCBheGqdSbCk0vRcGjzURkDs-TcmX9k_SG19fZI7DXGMR3_zkNxcj19LGfyLYb3ljgt16GNWecljhHHQxyNdf9_1jeTrWm_</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Višković, Klaudija</creator><creator>Marinelli, Annibale</creator><creator>Nedeljko, Katrin</creator><creator>Bržan, Petra Povalej</creator><creator>Bogdanić, Nikolina</creator><creator>Begovac, Josip</creator><general>Benham Science Publishers</general><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20230101</creationdate><title>High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study</title><author>Višković, Klaudija ; Marinelli, Annibale ; Nedeljko, Katrin ; Bržan, Petra Povalej ; Bogdanić, Nikolina ; Begovac, Josip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_29229527963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Antiretroviral drugs</topic><topic>Asymptomatic</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Calcification</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Cross-sectional studies</topic><topic>Diabetes</topic><topic>Hemodialysis</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Kidney diseases</topic><topic>Metabolic disorders</topic><topic>Nephrology</topic><topic>Regression analysis</topic><topic>Ultrasonic imaging</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Višković, Klaudija</creatorcontrib><creatorcontrib>Marinelli, Annibale</creatorcontrib><creatorcontrib>Nedeljko, Katrin</creatorcontrib><creatorcontrib>Bržan, Petra Povalej</creatorcontrib><creatorcontrib>Bogdanić, Nikolina</creatorcontrib><creatorcontrib>Begovac, Josip</creatorcontrib><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The open AIDS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Višković, Klaudija</au><au>Marinelli, Annibale</au><au>Nedeljko, Katrin</au><au>Bržan, Petra Povalej</au><au>Bogdanić, Nikolina</au><au>Begovac, Josip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study</atitle><jtitle>The open AIDS journal</jtitle><date>2023-01-01</date><risdate>2023</risdate><volume>17</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1874-6136</issn><eissn>1874-6136</eissn><abstract>Background: The association between HIV infection and increased risk of atherosclerotic peripheral artery disease (PAD) has been documented. Still, the relationship between HIV infection and lower extremity medial arterial calcification (MAC) is unknown. Objective: We performed a cross-sectional study to compare the frequency of MAC diagnosed by vascular ultrasound in PAD-asymptomatic people living with HIV (PLWH) with and without chronic kidney disease (CKD) compared to HIV-uninfected participants as a control group. Methods: MAC was defined as smooth, linear, and non-stenotic hyperechogenicity in the arterial wall compared to the surrounding tissues. We studied 191 patients: 50 PLWH (25 with an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73m2 and 25 with an eGFR <60 mL/min/ 1.73m2) and 141 HIV-uninfected patients (68 with eGFR<60 ml/min/L73m2). Results: MAC was most frequently found in PLWH with CKD (76%). The prevalence of MAC among PLWH was 54.0% (95% confidence interval [CI], 40.4-67.0%), whereas, in HIV-uninfected, it was 34.0% (95% CI, 26.7-42.2%, P=0.013). Age and CKD were consistently associated with MAC in our multivariable models, and there was also a sign that PLWH had higher odds of having MAC. Conclusion: We found a higher prevalence of MAC in PAD-asymptomatic PLWH compared to HIV-uninfected ones and provided evidence that HIV infection could be associated with MAC.</abstract><cop>Sharjah</cop><pub>Benham Science Publishers</pub><doi>10.2174/18746136-vl6-e221226-2022-11</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome AIDS Antiretroviral drugs Asymptomatic Atherosclerosis Blood pressure Body mass index Calcification Cardiovascular disease Coronary vessels Cross-sectional studies Diabetes Hemodialysis HIV Hospitals Human immunodeficiency virus Hypertension Infections Kidney diseases Metabolic disorders Nephrology Regression analysis Ultrasonic imaging Vein & artery diseases |
| title | High Prevalence of Lower Extremity Medial Arterial Calcification in HIVinfected Patients With and Without Chronic Renal Disease: A Vascular Ultrasound Cross-sectional Study |
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