Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents
Background New‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to...
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| Veröffentlicht in: | Pediatric transplantation 2024-02, Vol.28 (1), p.e14653-n/a |
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| creator | Horino, Satoshi Yamaguchi, Yuki Miyabayashi, Hiroki Aki, Haruka Nanjo, Yuka Onuma, Masaei Rikiishi, Takeshi Yabe, Hiromasa Imaizumi, Masue Sato, Atsushi Miura, Katsushi |
| description | Background
New‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to be established. The pathogenesis may differ from typical atopic dermatitis in terms of alloimmunity including graft‐versus‐host disease.
Methods
We present five children and adolescents with new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation. The characteristics and clinical profiles of skin treatment after hematopoietic stem cell transplantation are summarized.
Results
Graft‐versus‐host disease prophylaxis included systemic tacrolimus for all patients. After hematopoietic stem cell transplantation, all patients achieved complete donor chimerism of the bone marrow and had acute graft‐versus‐host disease of the skin. After engraftment, all patients had skin lesions that met the international consensus diagnostic criteria for atopic dermatitis. None of the patients met the diagnostic criteria for chronic graft‐versus‐host disease. Topical therapy and skin care based on atopic dermatitis guidelines improved skin condition and atopic dermatitis severity scores in all patients. In addition, type 2 inflammatory markers improved accordingly.
Conclusion
Topical therapy and skin care may be effective for transplant‐related atopic dermatitis after hematopoietic stem cell transplantation. When extensive dermatitis is observed after hematopoietic stem cell transplantation, this treatment may avoid excessive immunosuppressive therapy if it meets the diagnostic criteria for atopic dermatitis. |
| doi_str_mv | 10.1111/petr.14653 |
| format | Article |
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New‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to be established. The pathogenesis may differ from typical atopic dermatitis in terms of alloimmunity including graft‐versus‐host disease.
Methods
We present five children and adolescents with new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation. The characteristics and clinical profiles of skin treatment after hematopoietic stem cell transplantation are summarized.
Results
Graft‐versus‐host disease prophylaxis included systemic tacrolimus for all patients. After hematopoietic stem cell transplantation, all patients achieved complete donor chimerism of the bone marrow and had acute graft‐versus‐host disease of the skin. After engraftment, all patients had skin lesions that met the international consensus diagnostic criteria for atopic dermatitis. None of the patients met the diagnostic criteria for chronic graft‐versus‐host disease. Topical therapy and skin care based on atopic dermatitis guidelines improved skin condition and atopic dermatitis severity scores in all patients. In addition, type 2 inflammatory markers improved accordingly.
Conclusion
Topical therapy and skin care may be effective for transplant‐related atopic dermatitis after hematopoietic stem cell transplantation. When extensive dermatitis is observed after hematopoietic stem cell transplantation, this treatment may avoid excessive immunosuppressive therapy if it meets the diagnostic criteria for atopic dermatitis.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.14653</identifier><identifier>PMID: 37990976</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adolescents ; Allergic diseases ; Allografts ; Atopic dermatitis ; Bone marrow transplantation ; Child ; Children ; Chimerism ; Dermatitis ; Dermatitis, Atopic - complications ; Dermatitis, Atopic - therapy ; Disease ; Food allergies ; Graft vs Host Disease - etiology ; Graft vs Host Disease - prevention & control ; graft‐versus‐host disease ; hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Humans ; Immunosuppressive agents ; Inflammation ; Patients ; Prophylaxis ; Skin care ; Skin Care - adverse effects ; Skin diseases ; Skin lesions ; Stem cell transplantation ; Tacrolimus ; Teenagers ; Transplantation Conditioning - adverse effects ; Transplantation, Homologous - adverse effects</subject><ispartof>Pediatric transplantation, 2024-02, Vol.28 (1), p.e14653-n/a</ispartof><rights>2023 Wiley Periodicals LLC.</rights><rights>2024 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3193-771199216339abdd3e9e3e50a53c442643b2ff3b01f7d3725e3bab19bc8d1c493</cites><orcidid>0000-0002-3852-8041 ; 0000-0001-6394-3610 ; 0000-0001-6508-5496 ; 0000-0002-8385-4962 ; 0000-0002-1377-4756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.14653$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.14653$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37990976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horino, Satoshi</creatorcontrib><creatorcontrib>Yamaguchi, Yuki</creatorcontrib><creatorcontrib>Miyabayashi, Hiroki</creatorcontrib><creatorcontrib>Aki, Haruka</creatorcontrib><creatorcontrib>Nanjo, Yuka</creatorcontrib><creatorcontrib>Onuma, Masaei</creatorcontrib><creatorcontrib>Rikiishi, Takeshi</creatorcontrib><creatorcontrib>Yabe, Hiromasa</creatorcontrib><creatorcontrib>Imaizumi, Masue</creatorcontrib><creatorcontrib>Sato, Atsushi</creatorcontrib><creatorcontrib>Miura, Katsushi</creatorcontrib><title>Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Background
New‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to be established. The pathogenesis may differ from typical atopic dermatitis in terms of alloimmunity including graft‐versus‐host disease.
Methods
We present five children and adolescents with new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation. The characteristics and clinical profiles of skin treatment after hematopoietic stem cell transplantation are summarized.
Results
Graft‐versus‐host disease prophylaxis included systemic tacrolimus for all patients. After hematopoietic stem cell transplantation, all patients achieved complete donor chimerism of the bone marrow and had acute graft‐versus‐host disease of the skin. After engraftment, all patients had skin lesions that met the international consensus diagnostic criteria for atopic dermatitis. None of the patients met the diagnostic criteria for chronic graft‐versus‐host disease. Topical therapy and skin care based on atopic dermatitis guidelines improved skin condition and atopic dermatitis severity scores in all patients. In addition, type 2 inflammatory markers improved accordingly.
Conclusion
Topical therapy and skin care may be effective for transplant‐related atopic dermatitis after hematopoietic stem cell transplantation. When extensive dermatitis is observed after hematopoietic stem cell transplantation, this treatment may avoid excessive immunosuppressive therapy if it meets the diagnostic criteria for atopic dermatitis.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Allergic diseases</subject><subject>Allografts</subject><subject>Atopic dermatitis</subject><subject>Bone marrow transplantation</subject><subject>Child</subject><subject>Children</subject><subject>Chimerism</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - complications</subject><subject>Dermatitis, Atopic - therapy</subject><subject>Disease</subject><subject>Food allergies</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>graft‐versus‐host disease</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Immunosuppressive agents</subject><subject>Inflammation</subject><subject>Patients</subject><subject>Prophylaxis</subject><subject>Skin care</subject><subject>Skin Care - adverse effects</subject><subject>Skin diseases</subject><subject>Skin lesions</subject><subject>Stem cell transplantation</subject><subject>Tacrolimus</subject><subject>Teenagers</subject><subject>Transplantation Conditioning - adverse effects</subject><subject>Transplantation, Homologous - adverse effects</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1OwzAQRi0EoqWw4QDIEjukFNvjJvUSVeVHqgRCZR059oSmpEmwXaHuOAJn5CQkbWHJbGYW73sjfYScczbk7Vw3GNyQy3gEB6TPQakImIwPt3cSAZeiR068XzLGYzmWx6QHiVJMJXGfvM7rpjC6pGGBTjcbqitL_VtRUaMd0rx2NDhd-abUVfj-_NLe16bQAS3VoYtSi26lQxEKT7vUoiitw2rr0bYu0Rusgj8lR7kuPZ7t94C83E7nk_to9nj3MLmZRQa4gihJOFdK8BhA6cxaQIWAI6ZHYKQUsYRM5DlkjOeJhUSMEDKdcZWZseVGKhiQy523cfX7Gn1Il_XaVe3LVCghxBiAjVvqakcZV3vvME8bV6y026ScpV2naddpuu20hS_2ynW2QvuH_pbYAnwHfBQlbv5RpU_T-fNO-gM9xIO4</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Horino, Satoshi</creator><creator>Yamaguchi, Yuki</creator><creator>Miyabayashi, Hiroki</creator><creator>Aki, Haruka</creator><creator>Nanjo, Yuka</creator><creator>Onuma, Masaei</creator><creator>Rikiishi, Takeshi</creator><creator>Yabe, Hiromasa</creator><creator>Imaizumi, Masue</creator><creator>Sato, Atsushi</creator><creator>Miura, Katsushi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-3852-8041</orcidid><orcidid>https://orcid.org/0000-0001-6394-3610</orcidid><orcidid>https://orcid.org/0000-0001-6508-5496</orcidid><orcidid>https://orcid.org/0000-0002-8385-4962</orcidid><orcidid>https://orcid.org/0000-0002-1377-4756</orcidid></search><sort><creationdate>202402</creationdate><title>Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents</title><author>Horino, Satoshi ; Yamaguchi, Yuki ; Miyabayashi, Hiroki ; Aki, Haruka ; Nanjo, Yuka ; Onuma, Masaei ; Rikiishi, Takeshi ; Yabe, Hiromasa ; Imaizumi, Masue ; Sato, Atsushi ; Miura, Katsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3193-771199216339abdd3e9e3e50a53c442643b2ff3b01f7d3725e3bab19bc8d1c493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Allergic diseases</topic><topic>Allografts</topic><topic>Atopic dermatitis</topic><topic>Bone marrow transplantation</topic><topic>Child</topic><topic>Children</topic><topic>Chimerism</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - complications</topic><topic>Dermatitis, Atopic - therapy</topic><topic>Disease</topic><topic>Food allergies</topic><topic>Graft vs Host Disease - etiology</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>graft‐versus‐host disease</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Immunosuppressive agents</topic><topic>Inflammation</topic><topic>Patients</topic><topic>Prophylaxis</topic><topic>Skin care</topic><topic>Skin Care - adverse effects</topic><topic>Skin diseases</topic><topic>Skin lesions</topic><topic>Stem cell transplantation</topic><topic>Tacrolimus</topic><topic>Teenagers</topic><topic>Transplantation Conditioning - adverse effects</topic><topic>Transplantation, Homologous - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horino, Satoshi</creatorcontrib><creatorcontrib>Yamaguchi, Yuki</creatorcontrib><creatorcontrib>Miyabayashi, Hiroki</creatorcontrib><creatorcontrib>Aki, Haruka</creatorcontrib><creatorcontrib>Nanjo, Yuka</creatorcontrib><creatorcontrib>Onuma, Masaei</creatorcontrib><creatorcontrib>Rikiishi, Takeshi</creatorcontrib><creatorcontrib>Yabe, Hiromasa</creatorcontrib><creatorcontrib>Imaizumi, Masue</creatorcontrib><creatorcontrib>Sato, Atsushi</creatorcontrib><creatorcontrib>Miura, Katsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horino, Satoshi</au><au>Yamaguchi, Yuki</au><au>Miyabayashi, Hiroki</au><au>Aki, Haruka</au><au>Nanjo, Yuka</au><au>Onuma, Masaei</au><au>Rikiishi, Takeshi</au><au>Yabe, Hiromasa</au><au>Imaizumi, Masue</au><au>Sato, Atsushi</au><au>Miura, Katsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2024-02</date><risdate>2024</risdate><volume>28</volume><issue>1</issue><spage>e14653</spage><epage>n/a</epage><pages>e14653-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Background
New‐onset allergic diseases, such as food allergy or atopic dermatitis, can develop after allogeneic transplantation. There are limited reports of new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation in children and adolescents, and its treatment is yet to be established. The pathogenesis may differ from typical atopic dermatitis in terms of alloimmunity including graft‐versus‐host disease.
Methods
We present five children and adolescents with new‐onset atopic dermatitis after allogeneic hematopoietic stem cell transplantation. The characteristics and clinical profiles of skin treatment after hematopoietic stem cell transplantation are summarized.
Results
Graft‐versus‐host disease prophylaxis included systemic tacrolimus for all patients. After hematopoietic stem cell transplantation, all patients achieved complete donor chimerism of the bone marrow and had acute graft‐versus‐host disease of the skin. After engraftment, all patients had skin lesions that met the international consensus diagnostic criteria for atopic dermatitis. None of the patients met the diagnostic criteria for chronic graft‐versus‐host disease. Topical therapy and skin care based on atopic dermatitis guidelines improved skin condition and atopic dermatitis severity scores in all patients. In addition, type 2 inflammatory markers improved accordingly.
Conclusion
Topical therapy and skin care may be effective for transplant‐related atopic dermatitis after hematopoietic stem cell transplantation. When extensive dermatitis is observed after hematopoietic stem cell transplantation, this treatment may avoid excessive immunosuppressive therapy if it meets the diagnostic criteria for atopic dermatitis.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37990976</pmid><doi>10.1111/petr.14653</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3852-8041</orcidid><orcidid>https://orcid.org/0000-0001-6394-3610</orcidid><orcidid>https://orcid.org/0000-0001-6508-5496</orcidid><orcidid>https://orcid.org/0000-0002-8385-4962</orcidid><orcidid>https://orcid.org/0000-0002-1377-4756</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adolescents Allergic diseases Allografts Atopic dermatitis Bone marrow transplantation Child Children Chimerism Dermatitis Dermatitis, Atopic - complications Dermatitis, Atopic - therapy Disease Food allergies Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control graft‐versus‐host disease hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Immunosuppressive agents Inflammation Patients Prophylaxis Skin care Skin Care - adverse effects Skin diseases Skin lesions Stem cell transplantation Tacrolimus Teenagers Transplantation Conditioning - adverse effects Transplantation, Homologous - adverse effects |
| title | Topical therapy and skin care for transplant‐associated atopic dermatitis in children and adolescents |
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