Physicochemical characterization and biological effect of 3D-nanofibrous alumina scaffolds produced by solution blow spinning
The objective of this study was to conduct a physicochemical characterization and in vivo assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2024-02, Vol.26 (2), p.26, Article 26 |
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| creator | dos Reis, Danyella Carolyna Soares Linhares, Camila Rodrigues Borges da Costa Farias, Rosiane Maria Gomes, Deborah Santos de Araújo Neves, Gelmires Batista, Jonas Dantas Dechichi, Paula de Souza Castro Filice, Leticia Menezes, Romualdo Rodrigues Rocha, Flaviana Soares |
| description | The objective of this study was to conduct a physicochemical characterization and
in vivo
assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this research were derived from a solution containing aluminum nitrate, polyvinylpyrrolidone (PVP), ethanol, and distilled water, and were subsequently spun using SBS. The resulting scaffolds underwent calcination at 500 °C. Physicochemical analysis of the scaffolds was carried out, and their biological effects were evaluated in the femurs of Wistar rats. The scaffolds exhibited an amorphous structure consisting of nanofibers with an average diameter of 290 nm. They presented a cotton-wool-like 3D configuration after calcination process. Histomorphometric analysis revealed a significantly higher degree of bone neoformation within the alumina groups compared to the control group during both experimental periods (p |
| doi_str_mv | 10.1007/s11051-024-05934-3 |
| format | Article |
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in vivo
assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this research were derived from a solution containing aluminum nitrate, polyvinylpyrrolidone (PVP), ethanol, and distilled water, and were subsequently spun using SBS. The resulting scaffolds underwent calcination at 500 °C. Physicochemical analysis of the scaffolds was carried out, and their biological effects were evaluated in the femurs of Wistar rats. The scaffolds exhibited an amorphous structure consisting of nanofibers with an average diameter of 290 nm. They presented a cotton-wool-like 3D configuration after calcination process. Histomorphometric analysis revealed a significantly higher degree of bone neoformation within the alumina groups compared to the control group during both experimental periods (p < 0.05). Additionally, the percentage of remaining alumina graft particles was consistent at 14 and 28 days. In conclusion, the assessed 3D nanofibrous alumina scaffolds facilitated bone deposition and supported the filling of bone defects with new bone tissue.</description><identifier>ISSN: 1388-0764</identifier><identifier>EISSN: 1572-896X</identifier><identifier>DOI: 10.1007/s11051-024-05934-3</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alumina ; Aluminum ; Aluminum nitrate ; Aluminum oxide ; Biological activity ; Biological effects ; Bone growth ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Cotton ; Distilled water ; Ethanol ; In vivo methods and tests ; Inorganic Chemistry ; Lasers ; Materials Science ; Nanofibers ; Nanotechnology ; Optical Devices ; Optics ; Photonics ; Physical Chemistry ; Physicochemical analysis ; Polyvinylpyrrolidone ; Regeneration ; Regeneration (physiology) ; Research Paper ; Roasting ; Scaffolds</subject><ispartof>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2024-02, Vol.26 (2), p.26, Article 26</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-6293a13afa1cf01be7388c3a8b85f6f9199568142d7cebcd575a39068a8dfb403</cites><orcidid>0000-0002-6759-2229</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11051-024-05934-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11051-024-05934-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>dos Reis, Danyella Carolyna Soares</creatorcontrib><creatorcontrib>Linhares, Camila Rodrigues Borges</creatorcontrib><creatorcontrib>da Costa Farias, Rosiane Maria</creatorcontrib><creatorcontrib>Gomes, Deborah Santos</creatorcontrib><creatorcontrib>de Araújo Neves, Gelmires</creatorcontrib><creatorcontrib>Batista, Jonas Dantas</creatorcontrib><creatorcontrib>Dechichi, Paula</creatorcontrib><creatorcontrib>de Souza Castro Filice, Leticia</creatorcontrib><creatorcontrib>Menezes, Romualdo Rodrigues</creatorcontrib><creatorcontrib>Rocha, Flaviana Soares</creatorcontrib><title>Physicochemical characterization and biological effect of 3D-nanofibrous alumina scaffolds produced by solution blow spinning</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>The objective of this study was to conduct a physicochemical characterization and
in vivo
assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this research were derived from a solution containing aluminum nitrate, polyvinylpyrrolidone (PVP), ethanol, and distilled water, and were subsequently spun using SBS. The resulting scaffolds underwent calcination at 500 °C. Physicochemical analysis of the scaffolds was carried out, and their biological effects were evaluated in the femurs of Wistar rats. The scaffolds exhibited an amorphous structure consisting of nanofibers with an average diameter of 290 nm. They presented a cotton-wool-like 3D configuration after calcination process. Histomorphometric analysis revealed a significantly higher degree of bone neoformation within the alumina groups compared to the control group during both experimental periods (p < 0.05). Additionally, the percentage of remaining alumina graft particles was consistent at 14 and 28 days. In conclusion, the assessed 3D nanofibrous alumina scaffolds facilitated bone deposition and supported the filling of bone defects with new bone tissue.</description><subject>Alumina</subject><subject>Aluminum</subject><subject>Aluminum nitrate</subject><subject>Aluminum oxide</subject><subject>Biological activity</subject><subject>Biological effects</subject><subject>Bone growth</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Cotton</subject><subject>Distilled water</subject><subject>Ethanol</subject><subject>In vivo methods and tests</subject><subject>Inorganic Chemistry</subject><subject>Lasers</subject><subject>Materials Science</subject><subject>Nanofibers</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Physicochemical 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Rodrigues</au><au>Rocha, Flaviana Soares</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physicochemical characterization and biological effect of 3D-nanofibrous alumina scaffolds produced by solution blow spinning</atitle><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle><stitle>J Nanopart Res</stitle><date>2024-02-01</date><risdate>2024</risdate><volume>26</volume><issue>2</issue><spage>26</spage><pages>26-</pages><artnum>26</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>The objective of this study was to conduct a physicochemical characterization and
in vivo
assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this research were derived from a solution containing aluminum nitrate, polyvinylpyrrolidone (PVP), ethanol, and distilled water, and were subsequently spun using SBS. The resulting scaffolds underwent calcination at 500 °C. Physicochemical analysis of the scaffolds was carried out, and their biological effects were evaluated in the femurs of Wistar rats. The scaffolds exhibited an amorphous structure consisting of nanofibers with an average diameter of 290 nm. They presented a cotton-wool-like 3D configuration after calcination process. Histomorphometric analysis revealed a significantly higher degree of bone neoformation within the alumina groups compared to the control group during both experimental periods (p < 0.05). Additionally, the percentage of remaining alumina graft particles was consistent at 14 and 28 days. In conclusion, the assessed 3D nanofibrous alumina scaffolds facilitated bone deposition and supported the filling of bone defects with new bone tissue.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-024-05934-3</doi><orcidid>https://orcid.org/0000-0002-6759-2229</orcidid></addata></record> |
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| subjects | Alumina Aluminum Aluminum nitrate Aluminum oxide Biological activity Biological effects Bone growth Characterization and Evaluation of Materials Chemistry and Materials Science Cotton Distilled water Ethanol In vivo methods and tests Inorganic Chemistry Lasers Materials Science Nanofibers Nanotechnology Optical Devices Optics Photonics Physical Chemistry Physicochemical analysis Polyvinylpyrrolidone Regeneration Regeneration (physiology) Research Paper Roasting Scaffolds |
| title | Physicochemical characterization and biological effect of 3D-nanofibrous alumina scaffolds produced by solution blow spinning |
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