Effects of disorders in interdependent calcium and IP3 dynamics on nitric oxide production in a neuron cell
Calcium ([Ca 2+ ]), IP 3 , and nitric oxide (NO) play a significant role in cell signaling to maintain various physiological functions. Calcium and IP 3 regulation has been investigated independently in a variety of cells like myocyte, hepatocyte, and neuron cells. However, very little attention has...
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| Veröffentlicht in: | European physical journal plus 2022-05, Vol.137 (5), p.543, Article 543 |
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| creator | Pawar, Anand Raj Pardasani, Kamal |
| description | Calcium ([Ca
2+
]), IP
3
, and nitric oxide (NO) play a significant role in cell signaling to maintain various physiological functions. Calcium and IP
3
regulation has been investigated independently in a variety of cells like myocyte, hepatocyte, and neuron cells. However, very little attention has been paid to the study of interdependent calcium and IP
3
dynamics regulating nitric oxide production in neurons and other cells. Nitric oxide and its derivatives are reported to be involved in the pathogenic process leading to neurogenerative disorders like Parkinson’s disease. The production of nitric oxide depends on the calcium dynamics in a neuron cell. Therefore a model is proposed to study the regulatory and dysregulatory effects of interdependent calcium and IP
3
dynamics in a neuron cell. The system of reaction–diffusion equations for calcium and IP
3
is coupled with the production of nitric oxide in a neuron cell to formulate an initial boundary value problem. The finite element simulation is performed to obtain results for regulatory and dysregulatory conditions of interdependent calcium and IP
3
dynamics along with nitric oxide production in the cell. It is observed that disorders in mechanisms of calcium dynamics are balanced to some extent by IP3 dynamics. The dysregulation of calcium or IP3 dynamics causes an increase or decrease in nitric oxide production in the cell, which can lead to various neurodegenerative disorders. The information obtained from the present study can be used in the development of diagnostic and therapeutic measures. |
| doi_str_mv | 10.1140/epjp/s13360-022-02743-2 |
| format | Article |
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2+
]), IP
3
, and nitric oxide (NO) play a significant role in cell signaling to maintain various physiological functions. Calcium and IP
3
regulation has been investigated independently in a variety of cells like myocyte, hepatocyte, and neuron cells. However, very little attention has been paid to the study of interdependent calcium and IP
3
dynamics regulating nitric oxide production in neurons and other cells. Nitric oxide and its derivatives are reported to be involved in the pathogenic process leading to neurogenerative disorders like Parkinson’s disease. The production of nitric oxide depends on the calcium dynamics in a neuron cell. Therefore a model is proposed to study the regulatory and dysregulatory effects of interdependent calcium and IP
3
dynamics in a neuron cell. The system of reaction–diffusion equations for calcium and IP
3
is coupled with the production of nitric oxide in a neuron cell to formulate an initial boundary value problem. The finite element simulation is performed to obtain results for regulatory and dysregulatory conditions of interdependent calcium and IP
3
dynamics along with nitric oxide production in the cell. It is observed that disorders in mechanisms of calcium dynamics are balanced to some extent by IP3 dynamics. The dysregulation of calcium or IP3 dynamics causes an increase or decrease in nitric oxide production in the cell, which can lead to various neurodegenerative disorders. The information obtained from the present study can be used in the development of diagnostic and therapeutic measures.</description><identifier>ISSN: 2190-5444</identifier><identifier>EISSN: 2190-5444</identifier><identifier>DOI: 10.1140/epjp/s13360-022-02743-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Applied and Technical Physics ; Atomic ; Boundary value problems ; Calcium ; Calcium ions ; Complex Systems ; Condensed Matter Physics ; Cytotoxicity ; Dynamics ; Endoplasmic reticulum ; Enzymes ; Fibroblasts ; Finite element method ; Mathematical and Computational Physics ; Mathematical models ; Molecular ; Nervous system ; Neurons ; Nitric oxide ; Optical and Plasma Physics ; Parkinson's disease ; Physics ; Physics and Astronomy ; Reaction-diffusion equations ; Regular Article ; Regulation ; Theoretical</subject><ispartof>European physical journal plus, 2022-05, Vol.137 (5), p.543, Article 543</ispartof><rights>The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-72df05e21e7e2a96bb7a33ad26bd9c6af7c433beac26a27dae0334f32349e7153</citedby><cites>FETCH-LOGICAL-c388t-72df05e21e7e2a96bb7a33ad26bd9c6af7c433beac26a27dae0334f32349e7153</cites><orcidid>0000-0003-3464-208X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1140/epjp/s13360-022-02743-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920536718?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,27923,27924,33743,41487,42556,43804,51318,64384,64388,72340</link.rule.ids></links><search><creatorcontrib>Pawar, Anand</creatorcontrib><creatorcontrib>Raj Pardasani, Kamal</creatorcontrib><title>Effects of disorders in interdependent calcium and IP3 dynamics on nitric oxide production in a neuron cell</title><title>European physical journal plus</title><addtitle>Eur. Phys. J. Plus</addtitle><description>Calcium ([Ca
2+
]), IP
3
, and nitric oxide (NO) play a significant role in cell signaling to maintain various physiological functions. Calcium and IP
3
regulation has been investigated independently in a variety of cells like myocyte, hepatocyte, and neuron cells. However, very little attention has been paid to the study of interdependent calcium and IP
3
dynamics regulating nitric oxide production in neurons and other cells. Nitric oxide and its derivatives are reported to be involved in the pathogenic process leading to neurogenerative disorders like Parkinson’s disease. The production of nitric oxide depends on the calcium dynamics in a neuron cell. Therefore a model is proposed to study the regulatory and dysregulatory effects of interdependent calcium and IP
3
dynamics in a neuron cell. The system of reaction–diffusion equations for calcium and IP
3
is coupled with the production of nitric oxide in a neuron cell to formulate an initial boundary value problem. The finite element simulation is performed to obtain results for regulatory and dysregulatory conditions of interdependent calcium and IP
3
dynamics along with nitric oxide production in the cell. It is observed that disorders in mechanisms of calcium dynamics are balanced to some extent by IP3 dynamics. The dysregulation of calcium or IP3 dynamics causes an increase or decrease in nitric oxide production in the cell, which can lead to various neurodegenerative disorders. The information obtained from the present study can be used in the development of diagnostic and therapeutic measures.</description><subject>Applied and Technical Physics</subject><subject>Atomic</subject><subject>Boundary value problems</subject><subject>Calcium</subject><subject>Calcium ions</subject><subject>Complex Systems</subject><subject>Condensed Matter Physics</subject><subject>Cytotoxicity</subject><subject>Dynamics</subject><subject>Endoplasmic reticulum</subject><subject>Enzymes</subject><subject>Fibroblasts</subject><subject>Finite element method</subject><subject>Mathematical and Computational Physics</subject><subject>Mathematical models</subject><subject>Molecular</subject><subject>Nervous system</subject><subject>Neurons</subject><subject>Nitric oxide</subject><subject>Optical and Plasma Physics</subject><subject>Parkinson's disease</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Reaction-diffusion equations</subject><subject>Regular Article</subject><subject>Regulation</subject><subject>Theoretical</subject><issn>2190-5444</issn><issn>2190-5444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkF1LwzAUhoMoOOZ-gwGv6_LVpr2UMXUw0Au9DmlyIpldWpMW3L83c4LeGRLOCZznTXgQuqbkllJBljDshmWinFekIIzlIwUv2BmaMdqQohRCnP_pL9EipR3JSzRUNGKG3tfOgRkT7h22PvXRQkzYh7xHyJcBgoUwYqM746c91sHizTPH9hD03pvMBRz8GL3B_ae3gIfY28mMvj9GYI0DTDH3BrruCl043SVY_NQ5er1fv6wei-3Tw2Z1ty0Mr-uxkMw6UgKjIIHppmpbqTnXllWtbUylnTSC8xa0YZVm0mognAvHGRcNSFryObo55ea_fEyQRrXrpxjyk4o1jJS8krTOU_I0ZWKfUgSnhuj3Oh4UJeooVx3lqpNcleWqb7mKZbI-kSkT4Q3ib_5_6BcODIGM</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Pawar, Anand</creator><creator>Raj Pardasani, Kamal</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>P5Z</scope><scope>P62</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0003-3464-208X</orcidid></search><sort><creationdate>20220501</creationdate><title>Effects of disorders in interdependent calcium and IP3 dynamics on nitric oxide production in a neuron cell</title><author>Pawar, Anand ; Raj Pardasani, Kamal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-72df05e21e7e2a96bb7a33ad26bd9c6af7c433beac26a27dae0334f32349e7153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Applied and Technical Physics</topic><topic>Atomic</topic><topic>Boundary value problems</topic><topic>Calcium</topic><topic>Calcium ions</topic><topic>Complex Systems</topic><topic>Condensed Matter Physics</topic><topic>Cytotoxicity</topic><topic>Dynamics</topic><topic>Endoplasmic reticulum</topic><topic>Enzymes</topic><topic>Fibroblasts</topic><topic>Finite element method</topic><topic>Mathematical and Computational Physics</topic><topic>Mathematical models</topic><topic>Molecular</topic><topic>Nervous system</topic><topic>Neurons</topic><topic>Nitric oxide</topic><topic>Optical and Plasma Physics</topic><topic>Parkinson's disease</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Reaction-diffusion equations</topic><topic>Regular Article</topic><topic>Regulation</topic><topic>Theoretical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawar, Anand</creatorcontrib><creatorcontrib>Raj Pardasani, Kamal</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European physical journal plus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawar, Anand</au><au>Raj Pardasani, Kamal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of disorders in interdependent calcium and IP3 dynamics on nitric oxide production in a neuron cell</atitle><jtitle>European physical journal plus</jtitle><stitle>Eur. Phys. J. Plus</stitle><date>2022-05-01</date><risdate>2022</risdate><volume>137</volume><issue>5</issue><spage>543</spage><pages>543-</pages><artnum>543</artnum><issn>2190-5444</issn><eissn>2190-5444</eissn><abstract>Calcium ([Ca
2+
]), IP
3
, and nitric oxide (NO) play a significant role in cell signaling to maintain various physiological functions. Calcium and IP
3
regulation has been investigated independently in a variety of cells like myocyte, hepatocyte, and neuron cells. However, very little attention has been paid to the study of interdependent calcium and IP
3
dynamics regulating nitric oxide production in neurons and other cells. Nitric oxide and its derivatives are reported to be involved in the pathogenic process leading to neurogenerative disorders like Parkinson’s disease. The production of nitric oxide depends on the calcium dynamics in a neuron cell. Therefore a model is proposed to study the regulatory and dysregulatory effects of interdependent calcium and IP
3
dynamics in a neuron cell. The system of reaction–diffusion equations for calcium and IP
3
is coupled with the production of nitric oxide in a neuron cell to formulate an initial boundary value problem. The finite element simulation is performed to obtain results for regulatory and dysregulatory conditions of interdependent calcium and IP
3
dynamics along with nitric oxide production in the cell. It is observed that disorders in mechanisms of calcium dynamics are balanced to some extent by IP3 dynamics. The dysregulation of calcium or IP3 dynamics causes an increase or decrease in nitric oxide production in the cell, which can lead to various neurodegenerative disorders. The information obtained from the present study can be used in the development of diagnostic and therapeutic measures.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1140/epjp/s13360-022-02743-2</doi><orcidid>https://orcid.org/0000-0003-3464-208X</orcidid></addata></record> |
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| subjects | Applied and Technical Physics Atomic Boundary value problems Calcium Calcium ions Complex Systems Condensed Matter Physics Cytotoxicity Dynamics Endoplasmic reticulum Enzymes Fibroblasts Finite element method Mathematical and Computational Physics Mathematical models Molecular Nervous system Neurons Nitric oxide Optical and Plasma Physics Parkinson's disease Physics Physics and Astronomy Reaction-diffusion equations Regular Article Regulation Theoretical |
| title | Effects of disorders in interdependent calcium and IP3 dynamics on nitric oxide production in a neuron cell |
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