An α, β-unsaturated ketone alkylation and efficient reduction protocol for the synthesis of 3α-hydroxy-3β-methyl-4,4-dimethyl-5α-21-bromo-19-nor-pregnan-20-one

Alkyl-substituted testosterone derivatives are promising platforms for new drug discovery in medicinal chemistry. This approach provides a simple and efficient method for introducing an alkyl substituent to steroids at the C-4 position. In this study, the novel compound 3α-hydroxy-3β-methyl-4,4-dime...

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Veröffentlicht in:	Journal of chemical research 2023-09, Vol.47 (5)
Hauptverfasser:	Zhang, Mingguang, Wang, Wenlong, Guo, Cheng, Jiang, Chunhuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Bromination Carbonyl groups Carbonyls Grignard reactions Hydroboration Ketones Mass spectrometry Methylation NMR Nuclear magnetic resonance Oxidation Reduction Synthesis Testosterone
Online-Zugang:	Volltext
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