Biomarkers of Traumatic Brain Injury in the Geriatric Population
Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality, and advanced age is an independent predictor of worse outcome. Mortality is nearly double that of younger TBI patients, regardless of injury severity. In addition, geriatric patients are more prone to complications,...
Gespeichert in:
| Veröffentlicht in: | Current geriatrics reports 2012-09, Vol.1 (3), p.129-134 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 134 |
|---|---|
| container_issue | 3 |
| container_start_page | 129 |
| container_title | Current geriatrics reports |
| container_volume | 1 |
| creator | Rice, Darian Wang, Kevin K. W. Robicsek, Steven |
| description | Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality, and advanced age is an independent predictor of worse outcome. Mortality is nearly double that of younger TBI patients, regardless of injury severity. In addition, geriatric patients are more prone to complications, have longer hospital stays, and require long-term rehabilitative services, the cost of which can be a significant burden. These observations are often attributed to anatomic and physiologic changes that occur with age, as well as patient comorbidities and the medications required to treat those conditions. Although current diagnostic and treatment guidelines have led to improved outcomes in the general population, data regarding the specific management of geriatric patients remain sparse. The identification and management of TBI has been the focus of both basic science and clinical investigations. Recent advances in molecular biology have identified specific markers of brain cell damage that may offer insight to the nature and progression of injury, lead to improved monitoring and diagnostic capability, and potentially guide therapy. This review highlights some of the latest technology that may pave the way for advanced diagnostic and treatment modalities. |
| doi_str_mv | 10.1007/s13670-012-0022-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2920223207</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2920223207</sourcerecordid><originalsourceid>FETCH-LOGICAL-c289t-4bec8b9a1ea10681cd16a53bcdb9d95530980d164ae28b50fa74b78a3d09e6b93</originalsourceid><addsrcrecordid>eNp1UMtOwzAQtBBIVKUfwC0SZ8OunYd9g1ZQKlWCQzlbduJAQhsHOzn073EVJLiwl13tzsxqhpBrhFsEKO4C8rwACsgoAGM0OyMzhjmjqUzx_M98SRYhtBBLIGcoZuR-2biD9p_Wh8TVyc7r8aCHpkyWXjddsuna0R-TOA0fNllb3-jBx-ur68d9xLnuilzUeh_s4qfPydvT4271TLcv683qYUtLJuRAU2NLYaRGqxFygWWFuc64KSsjK5llHKSAuEu1ZcJkUOsiNYXQvAJpcyP5nNxMur13X6MNg2rd6Lv4UjHJomvOoIgonFCldyF4W6veN9HfUSGoU1ZqykrFrNQpK5VFDps4IWK7d-t_lf8nfQNrumrZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2920223207</pqid></control><display><type>article</type><title>Biomarkers of Traumatic Brain Injury in the Geriatric Population</title><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Rice, Darian ; Wang, Kevin K. W. ; Robicsek, Steven</creator><creatorcontrib>Rice, Darian ; Wang, Kevin K. W. ; Robicsek, Steven</creatorcontrib><description>Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality, and advanced age is an independent predictor of worse outcome. Mortality is nearly double that of younger TBI patients, regardless of injury severity. In addition, geriatric patients are more prone to complications, have longer hospital stays, and require long-term rehabilitative services, the cost of which can be a significant burden. These observations are often attributed to anatomic and physiologic changes that occur with age, as well as patient comorbidities and the medications required to treat those conditions. Although current diagnostic and treatment guidelines have led to improved outcomes in the general population, data regarding the specific management of geriatric patients remain sparse. The identification and management of TBI has been the focus of both basic science and clinical investigations. Recent advances in molecular biology have identified specific markers of brain cell damage that may offer insight to the nature and progression of injury, lead to improved monitoring and diagnostic capability, and potentially guide therapy. This review highlights some of the latest technology that may pave the way for advanced diagnostic and treatment modalities.</description><identifier>ISSN: 2162-4941</identifier><identifier>ISSN: 2196-7865</identifier><identifier>EISSN: 2162-4941</identifier><identifier>EISSN: 2196-7865</identifier><identifier>DOI: 10.1007/s13670-012-0022-5</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Age ; Baby boomers ; Biomarkers ; Cardiac arrhythmia ; Comorbidity ; Dementia ; Disease prevention ; Edema ; Falls ; Geriatrics ; Geriatrics/Gerontology ; Head injuries ; Hematoma ; Hypertension ; Ischemia ; Medicine ; Medicine & Public Health ; Metabolism ; Mortality ; Neurology ; Older people ; Oxidative stress ; Pain Medicine ; Population ; Psychopharmacology ; Rheumatology ; Section Editor ; Traumatic brain injury ; Traumatic Brain Injury and Dementia (K Wang</subject><ispartof>Current geriatrics reports, 2012-09, Vol.1 (3), p.129-134</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media, LLC 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-4bec8b9a1ea10681cd16a53bcdb9d95530980d164ae28b50fa74b78a3d09e6b93</citedby><cites>FETCH-LOGICAL-c289t-4bec8b9a1ea10681cd16a53bcdb9d95530980d164ae28b50fa74b78a3d09e6b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2920223207?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33744,43659,43805,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Rice, Darian</creatorcontrib><creatorcontrib>Wang, Kevin K. W.</creatorcontrib><creatorcontrib>Robicsek, Steven</creatorcontrib><title>Biomarkers of Traumatic Brain Injury in the Geriatric Population</title><title>Current geriatrics reports</title><addtitle>Curr Tran Geriatr Gerontol Rep</addtitle><description>Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality, and advanced age is an independent predictor of worse outcome. Mortality is nearly double that of younger TBI patients, regardless of injury severity. In addition, geriatric patients are more prone to complications, have longer hospital stays, and require long-term rehabilitative services, the cost of which can be a significant burden. These observations are often attributed to anatomic and physiologic changes that occur with age, as well as patient comorbidities and the medications required to treat those conditions. Although current diagnostic and treatment guidelines have led to improved outcomes in the general population, data regarding the specific management of geriatric patients remain sparse. The identification and management of TBI has been the focus of both basic science and clinical investigations. Recent advances in molecular biology have identified specific markers of brain cell damage that may offer insight to the nature and progression of injury, lead to improved monitoring and diagnostic capability, and potentially guide therapy. This review highlights some of the latest technology that may pave the way for advanced diagnostic and treatment modalities.</description><subject>Age</subject><subject>Baby boomers</subject><subject>Biomarkers</subject><subject>Cardiac arrhythmia</subject><subject>Comorbidity</subject><subject>Dementia</subject><subject>Disease prevention</subject><subject>Edema</subject><subject>Falls</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Head injuries</subject><subject>Hematoma</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Older people</subject><subject>Oxidative stress</subject><subject>Pain Medicine</subject><subject>Population</subject><subject>Psychopharmacology</subject><subject>Rheumatology</subject><subject>Section Editor</subject><subject>Traumatic brain injury</subject><subject>Traumatic Brain Injury and Dementia (K Wang</subject><issn>2162-4941</issn><issn>2196-7865</issn><issn>2162-4941</issn><issn>2196-7865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UMtOwzAQtBBIVKUfwC0SZ8OunYd9g1ZQKlWCQzlbduJAQhsHOzn073EVJLiwl13tzsxqhpBrhFsEKO4C8rwACsgoAGM0OyMzhjmjqUzx_M98SRYhtBBLIGcoZuR-2biD9p_Wh8TVyc7r8aCHpkyWXjddsuna0R-TOA0fNllb3-jBx-ur68d9xLnuilzUeh_s4qfPydvT4271TLcv683qYUtLJuRAU2NLYaRGqxFygWWFuc64KSsjK5llHKSAuEu1ZcJkUOsiNYXQvAJpcyP5nNxMur13X6MNg2rd6Lv4UjHJomvOoIgonFCldyF4W6veN9HfUSGoU1ZqykrFrNQpK5VFDps4IWK7d-t_lf8nfQNrumrZ</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Rice, Darian</creator><creator>Wang, Kevin K. W.</creator><creator>Robicsek, Steven</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20120901</creationdate><title>Biomarkers of Traumatic Brain Injury in the Geriatric Population</title><author>Rice, Darian ; Wang, Kevin K. W. ; Robicsek, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-4bec8b9a1ea10681cd16a53bcdb9d95530980d164ae28b50fa74b78a3d09e6b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Baby boomers</topic><topic>Biomarkers</topic><topic>Cardiac arrhythmia</topic><topic>Comorbidity</topic><topic>Dementia</topic><topic>Disease prevention</topic><topic>Edema</topic><topic>Falls</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Head injuries</topic><topic>Hematoma</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Older people</topic><topic>Oxidative stress</topic><topic>Pain Medicine</topic><topic>Population</topic><topic>Psychopharmacology</topic><topic>Rheumatology</topic><topic>Section Editor</topic><topic>Traumatic brain injury</topic><topic>Traumatic Brain Injury and Dementia (K Wang</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rice, Darian</creatorcontrib><creatorcontrib>Wang, Kevin K. W.</creatorcontrib><creatorcontrib>Robicsek, Steven</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Current geriatrics reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rice, Darian</au><au>Wang, Kevin K. W.</au><au>Robicsek, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of Traumatic Brain Injury in the Geriatric Population</atitle><jtitle>Current geriatrics reports</jtitle><stitle>Curr Tran Geriatr Gerontol Rep</stitle><date>2012-09-01</date><risdate>2012</risdate><volume>1</volume><issue>3</issue><spage>129</spage><epage>134</epage><pages>129-134</pages><issn>2162-4941</issn><issn>2196-7865</issn><eissn>2162-4941</eissn><eissn>2196-7865</eissn><abstract>Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality, and advanced age is an independent predictor of worse outcome. Mortality is nearly double that of younger TBI patients, regardless of injury severity. In addition, geriatric patients are more prone to complications, have longer hospital stays, and require long-term rehabilitative services, the cost of which can be a significant burden. These observations are often attributed to anatomic and physiologic changes that occur with age, as well as patient comorbidities and the medications required to treat those conditions. Although current diagnostic and treatment guidelines have led to improved outcomes in the general population, data regarding the specific management of geriatric patients remain sparse. The identification and management of TBI has been the focus of both basic science and clinical investigations. Recent advances in molecular biology have identified specific markers of brain cell damage that may offer insight to the nature and progression of injury, lead to improved monitoring and diagnostic capability, and potentially guide therapy. This review highlights some of the latest technology that may pave the way for advanced diagnostic and treatment modalities.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s13670-012-0022-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2162-4941 |
| ispartof | Current geriatrics reports, 2012-09, Vol.1 (3), p.129-134 |
| issn | 2162-4941 2196-7865 2162-4941 2196-7865 |
| language | eng |
| recordid | cdi_proquest_journals_2920223207 |
| source | ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Age Baby boomers Biomarkers Cardiac arrhythmia Comorbidity Dementia Disease prevention Edema Falls Geriatrics Geriatrics/Gerontology Head injuries Hematoma Hypertension Ischemia Medicine Medicine & Public Health Metabolism Mortality Neurology Older people Oxidative stress Pain Medicine Population Psychopharmacology Rheumatology Section Editor Traumatic brain injury Traumatic Brain Injury and Dementia (K Wang |
| title | Biomarkers of Traumatic Brain Injury in the Geriatric Population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A11%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomarkers%20of%20Traumatic%20Brain%20Injury%20in%20the%20Geriatric%20Population&rft.jtitle=Current%20geriatrics%20reports&rft.au=Rice,%20Darian&rft.date=2012-09-01&rft.volume=1&rft.issue=3&rft.spage=129&rft.epage=134&rft.pages=129-134&rft.issn=2162-4941&rft.eissn=2162-4941&rft_id=info:doi/10.1007/s13670-012-0022-5&rft_dat=%3Cproquest_cross%3E2920223207%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2920223207&rft_id=info:pmid/&rfr_iscdi=true |