The Role of Constant Light Exposure in Various Periods of Postnatal Ontogenesis in the Development of Pathology and Mortality in Male Rats

The goal of the work is a comparative study of the effect of constant illumination depending on the time of onset of exposure (from one month to 14 months of age) on the development of a number of oncological and age-related diseases in male rats. The results of the study show that a decrease in the...

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Veröffentlicht in:Advances in gerontology 2019-04, Vol.9 (2), p.141-146
Hauptverfasser: Matveeva, Yu. P., Zhukova, O. V., Lotosh, T. A., Yunash, V. D., Bukalev, A. V., Vinogradova, I. A.
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container_end_page 146
container_issue 2
container_start_page 141
container_title Advances in gerontology
container_volume 9
creator Matveeva, Yu. P.
Zhukova, O. V.
Lotosh, T. A.
Yunash, V. D.
Bukalev, A. V.
Vinogradova, I. A.
description The goal of the work is a comparative study of the effect of constant illumination depending on the time of onset of exposure (from one month to 14 months of age) on the development of a number of oncological and age-related diseases in male rats. The results of the study show that a decrease in the functional activity of the pineal gland under the influence of constant illumination from one month of age increases the incidence of inflammatory, nontumor, and tumor genesis and leads to the rapid development of age-related pathology. Conversely, rat maintenance in constant light mode from 14 months of age slows the development of age-related pathology and reduces the incidence and development of malignant tumors.
doi_str_mv 10.1134/S2079057019020164
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subjects Age
Aging
Cataracts
Endocrine system
Fluorescent lighting
Geriatrics/Gerontology
Infections
Laboratory animals
Males
Medicine
Medicine & Public Health
Melatonin
Morbidity
Mortality
Pathology
Pneumonia
Rhinitis
Tumors
title The Role of Constant Light Exposure in Various Periods of Postnatal Ontogenesis in the Development of Pathology and Mortality in Male Rats
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