New Biginelli derivatives with trifluoro extension as inhibitors of epidermal growth factor receptor tyrosine kinase: molecular docking study in comparison with monastrol

New tetrahydropyrimidone derivatives with structural modifications of anti-cancer drug, monastrol, were synthesized, and molecular docking study of the interaction with epidermal growth factor receptor tyrosine kinase (EGFR-TK) was performed. The substituted aromatic part was derived from benzaldehy...

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