Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro
New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a...
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| Veröffentlicht in: | Advances in gerontology 2021-07, Vol.11 (3), p.261-267 |
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| container_title | Advances in gerontology |
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| creator | Ivko, O. M. Drobintseva, A. O. Leont’eva, D. O. Kvetnoy, I. M. Polyakova, V. O. Linkova, N. S. |
| description | New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a compensatory increase in the synthesis of L7A ribosomal protein. AEDG peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 22% the expression of ribosomal protein L7A in cultures of human pineal-gland cells with aging. KE peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 15% the expression of ribosomal protein L7A in cultures of human thymic cells with aging. The area of MitoTracker Red mitochondrial staining decreased and the compensatory expression of L7A ribosomal protein increased with aging of the pineal gland and thymic cells. Presumably, AEDG and KE peptides have a tissue-specific effect that normalizes the functions of mitochondria and ribosomes of pinealocytes and thymocytes. |
| doi_str_mv | 10.1134/S2079057021030061 |
| format | Article |
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M. ; Drobintseva, A. O. ; Leont’eva, D. O. ; Kvetnoy, I. M. ; Polyakova, V. O. ; Linkova, N. S.</creator><creatorcontrib>Ivko, O. M. ; Drobintseva, A. O. ; Leont’eva, D. O. ; Kvetnoy, I. M. ; Polyakova, V. O. ; Linkova, N. S.</creatorcontrib><description>New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a compensatory increase in the synthesis of L7A ribosomal protein. AEDG peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 22% the expression of ribosomal protein L7A in cultures of human pineal-gland cells with aging. KE peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 15% the expression of ribosomal protein L7A in cultures of human thymic cells with aging. The area of MitoTracker Red mitochondrial staining decreased and the compensatory expression of L7A ribosomal protein increased with aging of the pineal gland and thymic cells. 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KE peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 15% the expression of ribosomal protein L7A in cultures of human thymic cells with aging. The area of MitoTracker Red mitochondrial staining decreased and the compensatory expression of L7A ribosomal protein increased with aging of the pineal gland and thymic cells. Presumably, AEDG and KE peptides have a tissue-specific effect that normalizes the functions of mitochondria and ribosomes of pinealocytes and thymocytes.</description><subject>Aging</subject><subject>Cell growth</subject><subject>Dyes</subject><subject>Endocrine system</subject><subject>Geriatrics/Gerontology</subject><subject>Immune system</subject><subject>Lymphocytes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Mitochondria</subject><subject>Peptides</subject><subject>Production increases</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Thymus gland</subject><subject>Yeast</subject><issn>2079-0570</issn><issn>2079-0589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd9KwzAUh4soOOYewLuA19X8aZv1ssy5DScON70taZquGV1SkxTdA_mepk70QgyEnBy-73cuThBcIniNEIlu1hjSFMYUYgQJhAk6CQZ9K4TxOD39qSk8D0bW7qA_McQUwkHwsVBV0wnFBdAVyKa3M8BUCe6nYCVaJ0thgVbgQTrNa61KI1kD1o5JJdX2i3S1ANP31ghrpSd9yJMstNV7D66MdkIqsKQZeJOuBtm21zzTW_NuzxRYSSU8Omv6sP5u6sO-s2AimgYsFHiRzuiL4KxijRWj73cYPN9NN5N5uHycLSbZMuQEIRcixAnjCNK4KkhZUBQTXNJUJGla-U-JCeVxRJKYVwlNKKYVwWwcR6jAXBQMkWFwdcxtjX7thHX5TndG-ZE5TlFKCY6S1FPoSHGjrTWiylsj98wccgTzfiH5n4V4Bx8d61m1FeY3-X_pE-Bri0g</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Ivko, O. 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M.</au><au>Drobintseva, A. O.</au><au>Leont’eva, D. O.</au><au>Kvetnoy, I. M.</au><au>Polyakova, V. O.</au><au>Linkova, N. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro</atitle><jtitle>Advances in gerontology</jtitle><stitle>Adv Gerontol</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>11</volume><issue>3</issue><spage>261</spage><epage>267</epage><pages>261-267</pages><issn>2079-0570</issn><eissn>2079-0589</eissn><abstract>New molecular targets for the geroprotective activity of AEDG (epitalon) and KE (vilon) peptides were verified via confocal laser scanning microscopy. It was shown that the aging of pineal and thymic cells in vitro led to a decrease in the staining of MitoTracker Red mitochondria and that there is a compensatory increase in the synthesis of L7A ribosomal protein. AEDG peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 22% the expression of ribosomal protein L7A in cultures of human pineal-gland cells with aging. KE peptide increased the area of MitoTracker Red mitochondrial staining by 1.5 times and decreased by 15% the expression of ribosomal protein L7A in cultures of human thymic cells with aging. The area of MitoTracker Red mitochondrial staining decreased and the compensatory expression of L7A ribosomal protein increased with aging of the pineal gland and thymic cells. 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| subjects | Aging Cell growth Dyes Endocrine system Geriatrics/Gerontology Immune system Lymphocytes Medicine Medicine & Public Health Metabolism Mitochondria Peptides Production increases Proteins Ribonucleic acid RNA Thymus gland Yeast |
| title | Influence of AEDG and KE Peptides on Mitochondrial Staining and the Expression of Ribosomal Protein L7A with Aging of the Human Pineal Gland and Thymus Cell In Vitro |
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