Reaction of Microglia and Neurons of the Hippocampal CA1 Field to Chloral Hydrate in Old Rats
We studied the effect of chloral hydrate on the reaction of microglia and neurons of the hippocampal CA1 field in old Wistar rats. According to the results of morphological and immunohistochemical analysis, chloral hydrate at a dose of 400 mg/kg does not lead to a decrease in the population of neuro...
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| Veröffentlicht in: | Advances in gerontology 2021-10, Vol.11 (4), p.341-345 |
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| creator | Shcherbak, N. S. Yukina, G. Yu Gurbo, A. G. Sukhorukova, E. G. Sargsian, A. G. Barantsevich, E. R. Thomson, V. V. Galagudza, M. M. |
| description | We studied the effect of chloral hydrate on the reaction of microglia and neurons of the hippocampal CA1 field in old Wistar rats. According to the results of morphological and immunohistochemical analysis, chloral hydrate at a dose of 400 mg/kg does not lead to a decrease in the population of neurons in the stratum pyramidale in the hippocampal CA1 field in rats aged 24 months after 48 h. The reaction of microglia is registered as an increase in immunoreactivity to Iba1 and morphological transformations of microgliocytes without a considerable change in their number in the stratum oriens, stratum pyramidale, and stratum radiatum of the hippocampal CA1 as compared to non-anesthetized animals. Microglia activation following anesthesia with chloral hydrate may underlie the earlier shown cognitive impairment in aged rats. |
| doi_str_mv | 10.1134/S2079057021040123 |
| format | Article |
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S. ; Yukina, G. Yu ; Gurbo, A. G. ; Sukhorukova, E. G. ; Sargsian, A. G. ; Barantsevich, E. R. ; Thomson, V. V. ; Galagudza, M. M.</creator><creatorcontrib>Shcherbak, N. S. ; Yukina, G. Yu ; Gurbo, A. G. ; Sukhorukova, E. G. ; Sargsian, A. G. ; Barantsevich, E. R. ; Thomson, V. V. ; Galagudza, M. M.</creatorcontrib><description>We studied the effect of chloral hydrate on the reaction of microglia and neurons of the hippocampal CA1 field in old Wistar rats. According to the results of morphological and immunohistochemical analysis, chloral hydrate at a dose of 400 mg/kg does not lead to a decrease in the population of neurons in the stratum pyramidale in the hippocampal CA1 field in rats aged 24 months after 48 h. The reaction of microglia is registered as an increase in immunoreactivity to Iba1 and morphological transformations of microgliocytes without a considerable change in their number in the stratum oriens, stratum pyramidale, and stratum radiatum of the hippocampal CA1 as compared to non-anesthetized animals. Microglia activation following anesthesia with chloral hydrate may underlie the earlier shown cognitive impairment in aged rats.</description><identifier>ISSN: 2079-0570</identifier><identifier>EISSN: 2079-0589</identifier><identifier>DOI: 10.1134/S2079057021040123</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Age groups ; Antibodies ; Antigens ; Blood pressure ; Brain damage ; Brain research ; Edema ; General anesthesia ; Geriatrics ; Geriatrics/Gerontology ; Ischemia ; Medicine ; Medicine & Public Health ; Metabolism ; Morphology ; Physiology ; Software</subject><ispartof>Advances in gerontology, 2021-10, Vol.11 (4), p.341-345</ispartof><rights>Pleiades Publishing, Ltd. 2021. 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The reaction of microglia is registered as an increase in immunoreactivity to Iba1 and morphological transformations of microgliocytes without a considerable change in their number in the stratum oriens, stratum pyramidale, and stratum radiatum of the hippocampal CA1 as compared to non-anesthetized animals. Microglia activation following anesthesia with chloral hydrate may underlie the earlier shown cognitive impairment in aged rats.</description><subject>Age groups</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Blood pressure</subject><subject>Brain damage</subject><subject>Brain research</subject><subject>Edema</subject><subject>General anesthesia</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Morphology</subject><subject>Physiology</subject><subject>Software</subject><issn>2079-0570</issn><issn>2079-0589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UEtLAzEQDqJg0f4AbwHPq5Ok2WyOZbFWqBaqHmUZdrNtynazJumh_96Uih7EuczwPeZFyA2DO8bE5P6Vg9IgFXAGE2BcnJHREcpAFvr8p1ZwScYhbCGFBK4ARuRjZbCO1vXUtfTZ1t6tO4sU-4a-mL13fTgScWPo3A6Dq3E3YEfLKaMza7qGRkfLTed8AueHxmM01PZ0mZgVxnBNLlrsghl_5yvyPnt4K-fZYvn4VE4XWS1YHjOtwRRpKSVFg-1EKTQ5QC0LmUBRsFy2wkiWY4vc8EIJpeucJbapBUcU4orcnvoO3n3uTYjV1u19n0ZWXDMtk4HrpGInVboyBG_aavB2h_5QMaiOj6z-PDJ5-MkTkrZfG__b-X_TF2AVcSw</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Shcherbak, N. 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S.</au><au>Yukina, G. Yu</au><au>Gurbo, A. G.</au><au>Sukhorukova, E. G.</au><au>Sargsian, A. G.</au><au>Barantsevich, E. R.</au><au>Thomson, V. V.</au><au>Galagudza, M. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reaction of Microglia and Neurons of the Hippocampal CA1 Field to Chloral Hydrate in Old Rats</atitle><jtitle>Advances in gerontology</jtitle><stitle>Adv Gerontol</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>11</volume><issue>4</issue><spage>341</spage><epage>345</epage><pages>341-345</pages><issn>2079-0570</issn><eissn>2079-0589</eissn><abstract>We studied the effect of chloral hydrate on the reaction of microglia and neurons of the hippocampal CA1 field in old Wistar rats. 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| subjects | Age groups Antibodies Antigens Blood pressure Brain damage Brain research Edema General anesthesia Geriatrics Geriatrics/Gerontology Ischemia Medicine Medicine & Public Health Metabolism Morphology Physiology Software |
| title | Reaction of Microglia and Neurons of the Hippocampal CA1 Field to Chloral Hydrate in Old Rats |
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