The role of pressure in cancer growth
. The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenviron...
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| Veröffentlicht in: | European physical journal plus 2015-11, Vol.130 (11), p.224, Article 224 |
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| creator | Taloni, Alessandro Ben Amar, Martine Zapperi, Stefano La Porta, Caterina A.M. |
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The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenvironment is an important issue still to be fully explored. In order to grow, tumors have to overcome the mechanical resistance posed by the tissues in which they originate, while cancer cells involved in metastasis are often subject to fluid pressure. Here we review the recent literature describing the role of solid and fluid pressure on tumor growth and progression. We discuss a variety of
in vitro
experiments as well as computational models used to interpret them. We conclude discussing future perspectives. |
| doi_str_mv | 10.1140/epjp/i2015-15224-0 |
| format | Article |
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The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenvironment is an important issue still to be fully explored. In order to grow, tumors have to overcome the mechanical resistance posed by the tissues in which they originate, while cancer cells involved in metastasis are often subject to fluid pressure. Here we review the recent literature describing the role of solid and fluid pressure on tumor growth and progression. We discuss a variety of
in vitro
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The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenvironment is an important issue still to be fully explored. In order to grow, tumors have to overcome the mechanical resistance posed by the tissues in which they originate, while cancer cells involved in metastasis are often subject to fluid pressure. Here we review the recent literature describing the role of solid and fluid pressure on tumor growth and progression. We discuss a variety of
in vitro
experiments as well as computational models used to interpret them. We conclude discussing future perspectives.</description><subject>Applied and Technical Physics</subject><subject>Atomic</subject><subject>Cancer</subject><subject>Complex Systems</subject><subject>Condensed Matter Physics</subject><subject>External pressure</subject><subject>Fluid pressure</subject><subject>Focus Point on the Physics of Cancer</subject><subject>Literature reviews</subject><subject>Mathematical and Computational Physics</subject><subject>Molecular</subject><subject>Optical and Plasma Physics</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Review</subject><subject>Theoretical</subject><subject>Tumors</subject><issn>2190-5444</issn><issn>2190-5444</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kEtPwzAQhC0EElXpH-AUCXEM9Tqbh4-o4iVV4lLOluOu20QlDnYixL_HbZDgxF52DzOzo4-xa-B3AMiX1Lf9shEc8hRyITDlZ2wmQPI0R8TzP_clW4TQ8jgoASXO2O1mT4l3B0qcTXpPIYyekqZLjO4M-WTn3eewv2IXVh8CLX72nL09PmxWz-n69elldb9OTQZySAFLslDWHKxG1LWJ7ezWWFGYCisO2takRQnAixol2VyDEFvSlS4ok4ayObuZcnvvPkYKg2rd6Lv4UgkJMoeiKGRUiUllvAvBk1W9b961_1LA1ZGIOhJRJyLqRETxaMomU4jibkf-N_of1zcEHmRg</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Taloni, Alessandro</creator><creator>Ben Amar, Martine</creator><creator>Zapperi, Stefano</creator><creator>La Porta, Caterina A.M.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>P5Z</scope><scope>P62</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20151101</creationdate><title>The role of pressure in cancer growth</title><author>Taloni, Alessandro ; Ben Amar, Martine ; Zapperi, Stefano ; La Porta, Caterina A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-147ef17b01fa44abc140fdcf26c84801afbea271106b49ef5a122dea8a6e39ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Applied and Technical Physics</topic><topic>Atomic</topic><topic>Cancer</topic><topic>Complex Systems</topic><topic>Condensed Matter Physics</topic><topic>External pressure</topic><topic>Fluid pressure</topic><topic>Focus Point on the Physics of Cancer</topic><topic>Literature reviews</topic><topic>Mathematical and Computational Physics</topic><topic>Molecular</topic><topic>Optical and Plasma Physics</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Review</topic><topic>Theoretical</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taloni, Alessandro</creatorcontrib><creatorcontrib>Ben Amar, Martine</creatorcontrib><creatorcontrib>Zapperi, Stefano</creatorcontrib><creatorcontrib>La Porta, Caterina A.M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>European physical journal plus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taloni, Alessandro</au><au>Ben Amar, Martine</au><au>Zapperi, Stefano</au><au>La Porta, Caterina A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of pressure in cancer growth</atitle><jtitle>European physical journal plus</jtitle><stitle>Eur. Phys. J. Plus</stitle><date>2015-11-01</date><risdate>2015</risdate><volume>130</volume><issue>11</issue><spage>224</spage><pages>224-</pages><artnum>224</artnum><issn>2190-5444</issn><eissn>2190-5444</eissn><abstract>.
The response to external mechanical forces is increasingly seen as a crucial aspect of cancer growth and a topic where the contribution of physics ideas and methods is important. Understanding if tumor progression towards increased malignancy reflects the geometry and mechanics of the microenvironment is an important issue still to be fully explored. In order to grow, tumors have to overcome the mechanical resistance posed by the tissues in which they originate, while cancer cells involved in metastasis are often subject to fluid pressure. Here we review the recent literature describing the role of solid and fluid pressure on tumor growth and progression. We discuss a variety of
in vitro
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| subjects | Applied and Technical Physics Atomic Cancer Complex Systems Condensed Matter Physics External pressure Fluid pressure Focus Point on the Physics of Cancer Literature reviews Mathematical and Computational Physics Molecular Optical and Plasma Physics Physics Physics and Astronomy Review Theoretical Tumors |
| title | The role of pressure in cancer growth |
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