Effect of peptide geroprotectors on navigation learning in rats of different ages and caspase-3 systems in their brain structures

Effect of peptide geroprotectors on navigation learning in rats of different ages and caspase-3 systems in their brain structures

The effects of peptide geroprotectors, such as cortexin and pinealon, on the training of rats of different ages and the caspase-3 system in their brain structures were studied in the experimental model of acute hypoxic hypoxy. Regional changes were identified in the activity and the content of caspa...

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Veröffentlicht in:Advances in gerontology 2014, Vol.4 (1), p.37-41
Hauptverfasser: Mendzheritskii, A. M., Karantysh, G. V., Abramchuk, V. A., Ryzhak, G. A.
Format: Artikel
Sprache:eng
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Animal cognition
Cell death
Geriatrics/Gerontology
Gerontology
Hypoxia
Medicine
Medicine & Public Health
Pathology
Peptides
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container_issue 1
container_start_page 37
container_title Advances in gerontology
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creator Mendzheritskii, A. M.
Karantysh, G. V.
Abramchuk, V. A.
Ryzhak, G. A.
description The effects of peptide geroprotectors, such as cortexin and pinealon, on the training of rats of different ages and the caspase-3 system in their brain structures were studied in the experimental model of acute hypoxic hypoxy. Regional changes were identified in the activity and the content of caspase-3 in the cerebral cortex and brainstem structures of young and old rats under the influence of peptide preparations. It is suggested that the functional state of the caspase-3 system in the brain is one of the reasons for the ability of animals to learn. Compared with cortexin, pinealon has a greater positive effect on the learning of both young and old animals in the Morris labyrinth.
doi_str_mv 10.1134/S2079057014010068
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subjects Animal cognition
Cell death
Geriatrics/Gerontology
Gerontology
Hypoxia
Medicine
Medicine & Public Health
Pathology
Peptides
title Effect of peptide geroprotectors on navigation learning in rats of different ages and caspase-3 systems in their brain structures
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