The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease
The usage of glyphosate is increasing worldwide. Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in fa...
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| Veröffentlicht in: | Exposure and health 2022-09, Vol.14 (3), p.779-789 |
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| description | The usage of glyphosate is increasing worldwide. Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in farmers. This study aimed to evaluate the influence of co-exposure to glyphosate and metals or metalloids in chronic kidney disease (CKD). In this study, the urine samples from 55 patients with CKD and 100 participants without CKD were analyzed for glyphosate, arsenic (As), cadmium (Cd), and lead (Pb) concentrations, and estimated glomerular filtration rate (eGFR). Negative associations between glyphosate, AMPA, As, and Cd concentrations in the urine and eGFR were found for study subjects (
p
1 μg/g creatinine; OR = 1.01, 95% CI = 1.00–1.02). These results showed that glyphosate, AMPA, As, and Cd have an effect on CKD; notably, Cd, As, and glyphosate exposure can be important risk factors after stage 3a of CKD, and that there was a co-exposure effect of As and glyphosate in CKD after stage 3b. The potential health impacts of glyphosate should be considered, especial for patients with CKD and eGFR below 45 mL/min/1.73 m
2
. |
| doi_str_mv | 10.1007/s12403-021-00451-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2919357663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2919357663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-7eaacb46d235aff8897756d2334c1131f47a2b98edbadac3ce1120661bd8f3ab3</originalsourceid><addsrcrecordid>eNp9kF9LwzAUxYMoOOa-gE8BXxdNmjZtH0edUxz4MvExpMmN7diamrTgvr2tVXzz6Z4L59w_P4SuGb1llKZ3gUUx5YRGjFAaJ4zwMzSLRpGLLDn_1akQl2gRwp5SykTChtQMve0qwGtrQXfYWVw4sv5sXeg94M7hzeHUVi6oDpa4UOZY98clVo3BKx-gqTV2DS4q70b5XJsGTvi-DqACXKELqw4BFj91jl4f1rvikWxfNk_Faks0F7wjKSily1iYiCfK2izL0zQZOx5rxjizcaqiMs_AlMoozTUMZ1MhWGkyy1XJ5-hmmtt699FD6OTe9b4ZVsooZzlPhq_54Ioml_YuBA9Wtr4-Kn-SjMqRoZwYyoGh_GYoxxCfQmEwN-_g_0b_k_oCGoVy7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2919357663</pqid></control><display><type>article</type><title>The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease</title><source>ProQuest Central (Alumni Edition)</source><source>Springer Nature - Complete Springer Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Sung, Junne-Ming ; Chang, Wei-Hsiang ; Liu, Kuan-Hung ; Chen, Chung Yu ; Mahmudiono, Trias ; Wang, Wan-Ru ; Hsu, Ho-Chi ; Li, Zhen-Yi ; Chen, Hsiu-Ling</creator><creatorcontrib>Sung, Junne-Ming ; Chang, Wei-Hsiang ; Liu, Kuan-Hung ; Chen, Chung Yu ; Mahmudiono, Trias ; Wang, Wan-Ru ; Hsu, Ho-Chi ; Li, Zhen-Yi ; Chen, Hsiu-Ling</creatorcontrib><description>The usage of glyphosate is increasing worldwide. Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in farmers. This study aimed to evaluate the influence of co-exposure to glyphosate and metals or metalloids in chronic kidney disease (CKD). In this study, the urine samples from 55 patients with CKD and 100 participants without CKD were analyzed for glyphosate, arsenic (As), cadmium (Cd), and lead (Pb) concentrations, and estimated glomerular filtration rate (eGFR). Negative associations between glyphosate, AMPA, As, and Cd concentrations in the urine and eGFR were found for study subjects (
p
< 0.05). With regard to the effect of co-exposure, the odds ratios (OR) for subjects with an eGFR of < 60 mL/min/1.73 m
2
was significant because of the high Cd concentration (> 1 μg/g creatinine; OR = 7.57, 95% CI = 1.91–29.95). With regard to the effect of co-exposure, the OR for subjects with an of eGFR < 45 mL/min/1.73 m
2
was significant at high glyphosate concentration (> 1 μg/g creatinine; OR = 1.57, 95% CI = 1.13–2.16) and As concentration (> 1 μg/g creatinine; OR = 1.01, 95% CI = 1.00–1.02). These results showed that glyphosate, AMPA, As, and Cd have an effect on CKD; notably, Cd, As, and glyphosate exposure can be important risk factors after stage 3a of CKD, and that there was a co-exposure effect of As and glyphosate in CKD after stage 3b. The potential health impacts of glyphosate should be considered, especial for patients with CKD and eGFR below 45 mL/min/1.73 m
2
.</description><identifier>ISSN: 2451-9766</identifier><identifier>EISSN: 2451-9685</identifier><identifier>DOI: 10.1007/s12403-021-00451-3</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Apoptosis ; Aquatic Pollution ; Arsenic ; Cadmium ; Chemical oxygen demand ; Chronic illnesses ; Creatinine ; Drinking water ; Earth and Environmental Science ; Environment ; Environmental Health ; Epidermal growth factor receptors ; Exposure ; Glomerular filtration rate ; Glyphosate ; Heavy metals ; Kidney diseases ; Kidneys ; Kinases ; Lead ; Metabolites ; Original Paper ; Pollution ; Questionnaires ; Risk factors ; Urine ; Waste Water Technology ; Water and Health ; Water Management ; Water Pollution Control ; Water Quality/Water Pollution</subject><ispartof>Exposure and health, 2022-09, Vol.14 (3), p.779-789</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-7eaacb46d235aff8897756d2334c1131f47a2b98edbadac3ce1120661bd8f3ab3</citedby><cites>FETCH-LOGICAL-c363t-7eaacb46d235aff8897756d2334c1131f47a2b98edbadac3ce1120661bd8f3ab3</cites><orcidid>0000-0002-1209-6789</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12403-021-00451-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919357663?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21368,21369,27903,27904,33509,33723,41467,42536,43638,43784,51298,64362,64366,72216</link.rule.ids></links><search><creatorcontrib>Sung, Junne-Ming</creatorcontrib><creatorcontrib>Chang, Wei-Hsiang</creatorcontrib><creatorcontrib>Liu, Kuan-Hung</creatorcontrib><creatorcontrib>Chen, Chung Yu</creatorcontrib><creatorcontrib>Mahmudiono, Trias</creatorcontrib><creatorcontrib>Wang, Wan-Ru</creatorcontrib><creatorcontrib>Hsu, Ho-Chi</creatorcontrib><creatorcontrib>Li, Zhen-Yi</creatorcontrib><creatorcontrib>Chen, Hsiu-Ling</creatorcontrib><title>The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease</title><title>Exposure and health</title><addtitle>Expo Health</addtitle><description>The usage of glyphosate is increasing worldwide. Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in farmers. This study aimed to evaluate the influence of co-exposure to glyphosate and metals or metalloids in chronic kidney disease (CKD). In this study, the urine samples from 55 patients with CKD and 100 participants without CKD were analyzed for glyphosate, arsenic (As), cadmium (Cd), and lead (Pb) concentrations, and estimated glomerular filtration rate (eGFR). Negative associations between glyphosate, AMPA, As, and Cd concentrations in the urine and eGFR were found for study subjects (
p
< 0.05). With regard to the effect of co-exposure, the odds ratios (OR) for subjects with an eGFR of < 60 mL/min/1.73 m
2
was significant because of the high Cd concentration (> 1 μg/g creatinine; OR = 7.57, 95% CI = 1.91–29.95). With regard to the effect of co-exposure, the OR for subjects with an of eGFR < 45 mL/min/1.73 m
2
was significant at high glyphosate concentration (> 1 μg/g creatinine; OR = 1.57, 95% CI = 1.13–2.16) and As concentration (> 1 μg/g creatinine; OR = 1.01, 95% CI = 1.00–1.02). These results showed that glyphosate, AMPA, As, and Cd have an effect on CKD; notably, Cd, As, and glyphosate exposure can be important risk factors after stage 3a of CKD, and that there was a co-exposure effect of As and glyphosate in CKD after stage 3b. The potential health impacts of glyphosate should be considered, especial for patients with CKD and eGFR below 45 mL/min/1.73 m
2
.</description><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Arsenic</subject><subject>Cadmium</subject><subject>Chemical oxygen demand</subject><subject>Chronic illnesses</subject><subject>Creatinine</subject><subject>Drinking water</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Epidermal growth factor receptors</subject><subject>Exposure</subject><subject>Glomerular filtration rate</subject><subject>Glyphosate</subject><subject>Heavy metals</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Lead</subject><subject>Metabolites</subject><subject>Original Paper</subject><subject>Pollution</subject><subject>Questionnaires</subject><subject>Risk factors</subject><subject>Urine</subject><subject>Waste Water Technology</subject><subject>Water and Health</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Water Quality/Water Pollution</subject><issn>2451-9766</issn><issn>2451-9685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kF9LwzAUxYMoOOa-gE8BXxdNmjZtH0edUxz4MvExpMmN7diamrTgvr2tVXzz6Z4L59w_P4SuGb1llKZ3gUUx5YRGjFAaJ4zwMzSLRpGLLDn_1akQl2gRwp5SykTChtQMve0qwGtrQXfYWVw4sv5sXeg94M7hzeHUVi6oDpa4UOZY98clVo3BKx-gqTV2DS4q70b5XJsGTvi-DqACXKELqw4BFj91jl4f1rvikWxfNk_Faks0F7wjKSily1iYiCfK2izL0zQZOx5rxjizcaqiMs_AlMoozTUMZ1MhWGkyy1XJ5-hmmtt699FD6OTe9b4ZVsooZzlPhq_54Ioml_YuBA9Wtr4-Kn-SjMqRoZwYyoGh_GYoxxCfQmEwN-_g_0b_k_oCGoVy7g</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Sung, Junne-Ming</creator><creator>Chang, Wei-Hsiang</creator><creator>Liu, Kuan-Hung</creator><creator>Chen, Chung Yu</creator><creator>Mahmudiono, Trias</creator><creator>Wang, Wan-Ru</creator><creator>Hsu, Ho-Chi</creator><creator>Li, Zhen-Yi</creator><creator>Chen, Hsiu-Ling</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><orcidid>https://orcid.org/0000-0002-1209-6789</orcidid></search><sort><creationdate>20220901</creationdate><title>The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease</title><author>Sung, Junne-Ming ; 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Glyphosate and its major metabolite, aminomethylphosphonic acid (AMPA), are of potential toxicological concern in unknown chronic kidney disease (CKDu). As with Cd and other elements, glyphosate exposure has been reported as risk factor for CKDu in farmers. This study aimed to evaluate the influence of co-exposure to glyphosate and metals or metalloids in chronic kidney disease (CKD). In this study, the urine samples from 55 patients with CKD and 100 participants without CKD were analyzed for glyphosate, arsenic (As), cadmium (Cd), and lead (Pb) concentrations, and estimated glomerular filtration rate (eGFR). Negative associations between glyphosate, AMPA, As, and Cd concentrations in the urine and eGFR were found for study subjects (
p
< 0.05). With regard to the effect of co-exposure, the odds ratios (OR) for subjects with an eGFR of < 60 mL/min/1.73 m
2
was significant because of the high Cd concentration (> 1 μg/g creatinine; OR = 7.57, 95% CI = 1.91–29.95). With regard to the effect of co-exposure, the OR for subjects with an of eGFR < 45 mL/min/1.73 m
2
was significant at high glyphosate concentration (> 1 μg/g creatinine; OR = 1.57, 95% CI = 1.13–2.16) and As concentration (> 1 μg/g creatinine; OR = 1.01, 95% CI = 1.00–1.02). These results showed that glyphosate, AMPA, As, and Cd have an effect on CKD; notably, Cd, As, and glyphosate exposure can be important risk factors after stage 3a of CKD, and that there was a co-exposure effect of As and glyphosate in CKD after stage 3b. The potential health impacts of glyphosate should be considered, especial for patients with CKD and eGFR below 45 mL/min/1.73 m
2
.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s12403-021-00451-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1209-6789</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Aquatic Pollution Arsenic Cadmium Chemical oxygen demand Chronic illnesses Creatinine Drinking water Earth and Environmental Science Environment Environmental Health Epidermal growth factor receptors Exposure Glomerular filtration rate Glyphosate Heavy metals Kidney diseases Kidneys Kinases Lead Metabolites Original Paper Pollution Questionnaires Risk factors Urine Waste Water Technology Water and Health Water Management Water Pollution Control Water Quality/Water Pollution |
| title | The Effect of Co-Exposure to Glyphosate, Cadmium, and Arsenic on Chronic Kidney Disease |
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