Fiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors
Purpose of Review To review recent data on the role and interactions of fiber and fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans. Recent Findings Fiber intake shows convincing and linear dose-response negative correlation with CRC risk. Dietary fiber stimulates bu...
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| Veröffentlicht in: | Current gastroenterology reports 2019-11, Vol.21 (11), p.62, Article 62 |
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| creator | Ocvirk, Soeren Wilson, Annette S. Appolonia, Corynn N. Thomas, Timothy K. O’Keefe, Stephen J. D. |
| description | Purpose of Review
To review recent data on the role and interactions of fiber and fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans.
Recent Findings
Fiber intake shows convincing and linear dose-response negative correlation with CRC risk. Dietary fiber stimulates butyrogenic activity of the gut microbiota, providing high amounts of butyrate that shows extensive anti-neoplastic effects. A high-fat diet promotes CRC risk through stimulated bile acid metabolism, facilitating bile acid conversion by the gut microbiota to tumor-promoting deoxycholic acid. Comprehensive interactions of these microbial metabolites are likely to underlie mechanisms driving diet-dependent CRC risk in different populations, but require further experimental investigation.
Summary
Dietary fiber and fat shape the composition and metabolic function of the gut microbiota, resulting in altered amounts of butyrate and deoxycholic acid in the colon. Fiber supplementation and restriction of fat intake represent promising strategies to reduce CRC risk in healthy individuals. |
| doi_str_mv | 10.1007/s11894-019-0725-2 |
| format | Article |
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To review recent data on the role and interactions of fiber and fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans.
Recent Findings
Fiber intake shows convincing and linear dose-response negative correlation with CRC risk. Dietary fiber stimulates butyrogenic activity of the gut microbiota, providing high amounts of butyrate that shows extensive anti-neoplastic effects. A high-fat diet promotes CRC risk through stimulated bile acid metabolism, facilitating bile acid conversion by the gut microbiota to tumor-promoting deoxycholic acid. Comprehensive interactions of these microbial metabolites are likely to underlie mechanisms driving diet-dependent CRC risk in different populations, but require further experimental investigation.
Summary
Dietary fiber and fat shape the composition and metabolic function of the gut microbiota, resulting in altered amounts of butyrate and deoxycholic acid in the colon. Fiber supplementation and restriction of fat intake represent promising strategies to reduce CRC risk in healthy individuals.</description><identifier>ISSN: 1522-8037</identifier><identifier>EISSN: 1534-312X</identifier><identifier>DOI: 10.1007/s11894-019-0725-2</identifier><identifier>PMID: 31792624</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bacteria ; Bile Acids and Salts - metabolism ; Colorectal cancer ; Colorectal Neoplasms - etiology ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - microbiology ; Colorectal Neoplasms - prevention & control ; Diet ; Diet, High-Fat - adverse effects ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Dietary Fats - pharmacology ; Dietary fiber ; Dietary Fiber - administration & dosage ; Feces ; Gastroenterology ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal Microbiome - physiology ; GI Oncology (R Bresalier ; Humans ; Inflammatory bowel disease ; Meat ; Medicine ; Medicine & Public Health ; Metabolism ; Metabolites ; Microbiota ; Oils & fats ; Risk Factors ; Section Editor ; Topical Collection on GI Oncology ; Tumorigenesis</subject><ispartof>Current gastroenterology reports, 2019-11, Vol.21 (11), p.62, Article 62</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2872-222e9e9b1db0880f19ca0fb0800142d86947014246f59303389d8e3f294d2ae93</citedby><cites>FETCH-LOGICAL-c2872-222e9e9b1db0880f19ca0fb0800142d86947014246f59303389d8e3f294d2ae93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11894-019-0725-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918765220?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33744,41488,42557,43659,43805,51319,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31792624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ocvirk, Soeren</creatorcontrib><creatorcontrib>Wilson, Annette S.</creatorcontrib><creatorcontrib>Appolonia, Corynn N.</creatorcontrib><creatorcontrib>Thomas, Timothy K.</creatorcontrib><creatorcontrib>O’Keefe, Stephen J. D.</creatorcontrib><title>Fiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors</title><title>Current gastroenterology reports</title><addtitle>Curr Gastroenterol Rep</addtitle><addtitle>Curr Gastroenterol Rep</addtitle><description>Purpose of Review
To review recent data on the role and interactions of fiber and fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans.
Recent Findings
Fiber intake shows convincing and linear dose-response negative correlation with CRC risk. Dietary fiber stimulates butyrogenic activity of the gut microbiota, providing high amounts of butyrate that shows extensive anti-neoplastic effects. A high-fat diet promotes CRC risk through stimulated bile acid metabolism, facilitating bile acid conversion by the gut microbiota to tumor-promoting deoxycholic acid. Comprehensive interactions of these microbial metabolites are likely to underlie mechanisms driving diet-dependent CRC risk in different populations, but require further experimental investigation.
Summary
Dietary fiber and fat shape the composition and metabolic function of the gut microbiota, resulting in altered amounts of butyrate and deoxycholic acid in the colon. Fiber supplementation and restriction of fat intake represent promising strategies to reduce CRC risk in healthy individuals.</description><subject>Bacteria</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Dietary Fats - pharmacology</subject><subject>Dietary fiber</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Feces</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>GI Oncology (R Bresalier</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Meat</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Oils & fats</subject><subject>Risk Factors</subject><subject>Section Editor</subject><subject>Topical Collection on GI Oncology</subject><subject>Tumorigenesis</subject><issn>1522-8037</issn><issn>1534-312X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kF9LwzAUxYMobk4_gC8S8HXR5KZrE9-kOh1MBf-AbyFt09nZNTPpEL-9KZ365NM9cM85N_khdMzoGaM0OfeMCRkRyiShCUwI7KAhm_CIcAavu50GIILyZIAOvF9SCiEV76MBZ4mEGKIheppWmXFjPNXtGOumwKmtrTN5q2uc6iY37gLfm088a3y1eGtx1bQW39miKiud1QZfVabV7gs_Vv49lOStdf4Q7ZW69uZoO0foZXr9nN6S-cPNLL2ckxxEAgQAjDQyY0VGhaAlk7mmZdCUsggKEcso6VQUlxPJKedCFsLwEmRUgDaSj9Bp37t29mNjfKuWduOacFKBZCKJw_dpcLHelTvrvTOlWrtqFd6sGFUdRtVjVAGj6jAqCJmTbfMmW5niN_HDLRigN_iwahbG_Z3-v_Ubdpp6CQ</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Ocvirk, Soeren</creator><creator>Wilson, Annette S.</creator><creator>Appolonia, Corynn N.</creator><creator>Thomas, Timothy K.</creator><creator>O’Keefe, Stephen J. D.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20191101</creationdate><title>Fiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors</title><author>Ocvirk, Soeren ; Wilson, Annette S. ; Appolonia, Corynn N. ; Thomas, Timothy K. ; O’Keefe, Stephen J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2872-222e9e9b1db0880f19ca0fb0800142d86947014246f59303389d8e3f294d2ae93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bacteria</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - microbiology</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Dietary Fats - pharmacology</topic><topic>Dietary fiber</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Feces</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>GI Oncology (R Bresalier</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Meat</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Oils & fats</topic><topic>Risk Factors</topic><topic>Section Editor</topic><topic>Topical Collection on GI Oncology</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ocvirk, Soeren</creatorcontrib><creatorcontrib>Wilson, Annette S.</creatorcontrib><creatorcontrib>Appolonia, Corynn N.</creatorcontrib><creatorcontrib>Thomas, Timothy K.</creatorcontrib><creatorcontrib>O’Keefe, Stephen J. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Current gastroenterology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ocvirk, Soeren</au><au>Wilson, Annette S.</au><au>Appolonia, Corynn N.</au><au>Thomas, Timothy K.</au><au>O’Keefe, Stephen J. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors</atitle><jtitle>Current gastroenterology reports</jtitle><stitle>Curr Gastroenterol Rep</stitle><addtitle>Curr Gastroenterol Rep</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>21</volume><issue>11</issue><spage>62</spage><pages>62-</pages><artnum>62</artnum><issn>1522-8037</issn><eissn>1534-312X</eissn><abstract>Purpose of Review
To review recent data on the role and interactions of fiber and fat as dietary risk factors associated with colorectal cancer (CRC) risk in humans.
Recent Findings
Fiber intake shows convincing and linear dose-response negative correlation with CRC risk. Dietary fiber stimulates butyrogenic activity of the gut microbiota, providing high amounts of butyrate that shows extensive anti-neoplastic effects. A high-fat diet promotes CRC risk through stimulated bile acid metabolism, facilitating bile acid conversion by the gut microbiota to tumor-promoting deoxycholic acid. Comprehensive interactions of these microbial metabolites are likely to underlie mechanisms driving diet-dependent CRC risk in different populations, but require further experimental investigation.
Summary
Dietary fiber and fat shape the composition and metabolic function of the gut microbiota, resulting in altered amounts of butyrate and deoxycholic acid in the colon. Fiber supplementation and restriction of fat intake represent promising strategies to reduce CRC risk in healthy individuals.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31792624</pmid><doi>10.1007/s11894-019-0725-2</doi></addata></record> |
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| subjects | Bacteria Bile Acids and Salts - metabolism Colorectal cancer Colorectal Neoplasms - etiology Colorectal Neoplasms - metabolism Colorectal Neoplasms - microbiology Colorectal Neoplasms - prevention & control Diet Diet, High-Fat - adverse effects Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary Fats - pharmacology Dietary fiber Dietary Fiber - administration & dosage Feces Gastroenterology Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology GI Oncology (R Bresalier Humans Inflammatory bowel disease Meat Medicine Medicine & Public Health Metabolism Metabolites Microbiota Oils & fats Risk Factors Section Editor Topical Collection on GI Oncology Tumorigenesis |
| title | Fiber, Fat, and Colorectal Cancer: New Insight into Modifiable Dietary Risk Factors |
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