Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes
2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences....
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| Veröffentlicht in: | Frontiers of environmental science & engineering 2013-02, Vol.7 (1), p.77-84 |
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| creator | Liu, Nannan Ma, Mei Xu, Yiping Zha, Jinmiao Rao, Kaifeng Wang, Zijian |
| description | 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L⁻¹. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure. |
| doi_str_mv | 10.1007/s11783-012-0466-z |
| format | Article |
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However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L⁻¹. 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Environ. Sci. Eng</addtitle><description>2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L⁻¹. This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP in vivo exposure.</description><subject>2,4,6-Trichlorophenol</subject><subject>Biomedical materials</subject><subject>Carcinogens</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Erythrocytes</subject><subject>Exposure</subject><subject>Females</subject><subject>fish</subject><subject>gender difference</subject><subject>Genotoxicity</subject><subject>humans</subject><subject>in vitro studies</subject><subject>In vivo methods and tests</subject><subject>Japanese medaka</subject><subject>males</subject><subject>Micronuclei</subject><subject>Oryzias latipes</subject><subject>piscine micronucleus test in peripheral erythrocytes</subject><subject>Research Article</subject><subject>Sex</subject><subject>Trichlorophenol</subject><subject>Trichlorophenols</subject><issn>2095-2201</issn><issn>2095-221X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctu1TAQhiMEElXpA7DCEhuQavAliZ0lqspNlbooldhZE2d8jktOHGxnkfMKvDQ-BMGus_Es_m9m9LmqXnL2jjOm3ifOlZaUcUFZ3bb0-KQ6E6xrqBD8-9N_PePPq4uUHlgprWuu5Vn1625JFufsez_6vJLgyAFGJDANxOGf9ivMMGFCcsABfgB5cxvXo4dERsh-xvSW5EDEZX3Z0hy93Y8hhnmPUxipn4bF4kAO3sYwLXZET_xEZoy-JCKMBOOa9zHYNWN6UT1zMCa8-PueV_cfr79dfaY3t5--XH24oVbqLtOB1U5i23QNF7rXFhx0vO6tbYRTAvpGou2dZEr1vUWGTEmrBgGgQfN6aOV59XqbO8fwc8GUzUNY4lRWGtFxrWqh-CnFt1Q5PaWIzszRHyCuhjNz0m427aZoNyft5lgYsTGpZKcdxv-TH4P0Bu39rkjBYY6YknHFWPYYH0dfbaiDYGAXfTL3d-Wfa8Z4W2vB5W9mRKQX</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Liu, Nannan</creator><creator>Ma, Mei</creator><creator>Xu, Yiping</creator><creator>Zha, Jinmiao</creator><creator>Rao, Kaifeng</creator><creator>Wang, Zijian</creator><general>Springer-Verlag</general><general>Higher Education Press</general><general>SP Higher Education Press</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope></search><sort><creationdate>20130201</creationdate><title>Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes</title><author>Liu, Nannan ; Ma, Mei ; Xu, Yiping ; Zha, Jinmiao ; Rao, Kaifeng ; Wang, Zijian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d04f3e6595128b8cafa914bcc52f72ab53ecbf3077bbce0e073c7d2aa8a814d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2,4,6-Trichlorophenol</topic><topic>Biomedical materials</topic><topic>Carcinogens</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Erythrocytes</topic><topic>Exposure</topic><topic>Females</topic><topic>fish</topic><topic>gender difference</topic><topic>Genotoxicity</topic><topic>humans</topic><topic>in vitro studies</topic><topic>In vivo methods and tests</topic><topic>Japanese medaka</topic><topic>males</topic><topic>Micronuclei</topic><topic>Oryzias latipes</topic><topic>piscine micronucleus test in peripheral erythrocytes</topic><topic>Research Article</topic><topic>Sex</topic><topic>Trichlorophenol</topic><topic>Trichlorophenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Nannan</creatorcontrib><creatorcontrib>Ma, Mei</creatorcontrib><creatorcontrib>Xu, Yiping</creatorcontrib><creatorcontrib>Zha, Jinmiao</creatorcontrib><creatorcontrib>Rao, Kaifeng</creatorcontrib><creatorcontrib>Wang, Zijian</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><jtitle>Frontiers of environmental science & engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Nannan</au><au>Ma, Mei</au><au>Xu, Yiping</au><au>Zha, Jinmiao</au><au>Rao, Kaifeng</au><au>Wang, Zijian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes</atitle><jtitle>Frontiers of environmental science & engineering</jtitle><stitle>Front Envir Sci Eng</stitle><stitle>Front. Environ. Sci. Eng</stitle><date>2013-02-01</date><risdate>2013</risdate><volume>7</volume><issue>1</issue><spage>77</spage><epage>84</epage><pages>77-84</pages><issn>2095-2201</issn><eissn>2095-221X</eissn><abstract>2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in in vitro assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from in vivo tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka (Oryzias latipes) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. 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| subjects | 2,4,6-Trichlorophenol Biomedical materials Carcinogens Earth and Environmental Science Environment Erythrocytes Exposure Females fish gender difference Genotoxicity humans in vitro studies In vivo methods and tests Japanese medaka males Micronuclei Oryzias latipes piscine micronucleus test in peripheral erythrocytes Research Article Sex Trichlorophenol Trichlorophenols |
| title | Susceptibility of male and female Japanese medaka (Oryzias latipes) to 2,4,6-trichlorophenol-induced micronuclei in peripheral erythrocytes |
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