Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels
Objective To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms. Methods A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases...
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| Veröffentlicht in: | Journal of acupuncture and tuina science 2020-06, Vol.18 (3), p.213-218 |
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| creator | Li, Juan Liu, Gui-ping |
| description | Objective
To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms.
Methods
A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs. Both groups were treated for 3 months. Before and after treatment, assessed the visual analog scale (VAS) and Oswestry disability index (ODI) scores, determined the bone mineral density of the participants’ lumbar spine (L
2
-L
4
) and left femoral neck, and detected the participants’ serum bone morphogenetic protein-2 (BMP-2) and osteoprotegerin (OPG) levels.
Results
After treatment, the VAS scores of both groups were lower than before treatment (both
P |
| doi_str_mv | 10.1007/s11726-020-1180-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918733261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918733261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-553c72674900131927baee2349b6eaa9348cfebf65b08b04b10120f6b7960abf3</originalsourceid><addsrcrecordid>eNp1kM1OHDEQhEcoSNlseIDcLHF28M-OPT6SFT-RQHCAs2UPbTCaHU_cnhV5AZ4bLxuRExfbLX9Vraqm-cHZT86YPkHOtVCUCUY57-px0Cy4MZIyacyX-lZaUNka_bX5hvjMWKuVEIvm9e4JsptgLrEnEAL0haRAnsAVijBiLHELZJNeop-xxDSSaZiRbOAh9m43Iwkpk4rGAUjCAmlKOWFE4sYHEgt-uI6VyvOG_Lq-peL99-b2ggywhQG_N4fBDQhH_-5lc39-dre-pFc3F7_Xp1e0F6ortG1lX2PqlWGMS26E9g5AyJXxCpwzctX1AXxQrWedZyvPGRcsKK-NYs4HuWyO975TTn9mwGKf05zHutIKwzstpVC8UnxP9TUJZgh2ynHj8l_Lmd3Vbfd121q33dVtdxqx12Blx0fI_50_F70BC4-Dpw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918733261</pqid></control><display><type>article</type><title>Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>SpringerLink Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Li, Juan ; Liu, Gui-ping</creator><creatorcontrib>Li, Juan ; Liu, Gui-ping</creatorcontrib><description><![CDATA[Objective
To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms.
Methods
A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs. Both groups were treated for 3 months. Before and after treatment, assessed the visual analog scale (VAS) and Oswestry disability index (ODI) scores, determined the bone mineral density of the participants’ lumbar spine (L
2
-L
4
) and left femoral neck, and detected the participants’ serum bone morphogenetic protein-2 (BMP-2) and osteoprotegerin (OPG) levels.
Results
After treatment, the VAS scores of both groups were lower than before treatment (both
P
<0.05), and the VAS score of the observation group was significantly lower than that of the control group (
P
<0.05). After treatment, the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment (both
P
<0.05), and the bone mineral density values of the observation group were higher than those of the control group (
P
<0.05). After treatment, the ODI scores of the two groups were lower than those before treatment (both
P
<0.05), and the ODI score of the observation group was lower than that of the control group
(
P
<0.05). After treatment, the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group (both
P
<0.05).
Conclusion
Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients’ pain, improve dysfunction, and increase bone density, which may be related to the improvement of the serum BMP-2 and OPG levels.]]></description><identifier>ISSN: 1672-3597</identifier><identifier>EISSN: 1993-0399</identifier><identifier>DOI: 10.1007/s11726-020-1180-1</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Acupuncture ; Bone density ; Clinical Study ; Medicine ; Medicine & Public Health ; Osteoporosis</subject><ispartof>Journal of acupuncture and tuina science, 2020-06, Vol.18 (3), p.213-218</ispartof><rights>Shanghai Research Institute of Acupuncture and Meridian 2020</rights><rights>Shanghai Research Institute of Acupuncture and Meridian 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-553c72674900131927baee2349b6eaa9348cfebf65b08b04b10120f6b7960abf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11726-020-1180-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918733261?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,23256,27924,27925,33530,33703,33744,41488,42557,43659,43787,43805,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Liu, Gui-ping</creatorcontrib><title>Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels</title><title>Journal of acupuncture and tuina science</title><addtitle>J. Acupunct. Tuina. Sci</addtitle><description><![CDATA[Objective
To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms.
Methods
A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs. Both groups were treated for 3 months. Before and after treatment, assessed the visual analog scale (VAS) and Oswestry disability index (ODI) scores, determined the bone mineral density of the participants’ lumbar spine (L
2
-L
4
) and left femoral neck, and detected the participants’ serum bone morphogenetic protein-2 (BMP-2) and osteoprotegerin (OPG) levels.
Results
After treatment, the VAS scores of both groups were lower than before treatment (both
P
<0.05), and the VAS score of the observation group was significantly lower than that of the control group (
P
<0.05). After treatment, the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment (both
P
<0.05), and the bone mineral density values of the observation group were higher than those of the control group (
P
<0.05). After treatment, the ODI scores of the two groups were lower than those before treatment (both
P
<0.05), and the ODI score of the observation group was lower than that of the control group
(
P
<0.05). After treatment, the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group (both
P
<0.05).
Conclusion
Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients’ pain, improve dysfunction, and increase bone density, which may be related to the improvement of the serum BMP-2 and OPG levels.]]></description><subject>Acupuncture</subject><subject>Bone density</subject><subject>Clinical Study</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Osteoporosis</subject><issn>1672-3597</issn><issn>1993-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kM1OHDEQhEcoSNlseIDcLHF28M-OPT6SFT-RQHCAs2UPbTCaHU_cnhV5AZ4bLxuRExfbLX9Vraqm-cHZT86YPkHOtVCUCUY57-px0Cy4MZIyacyX-lZaUNka_bX5hvjMWKuVEIvm9e4JsptgLrEnEAL0haRAnsAVijBiLHELZJNeop-xxDSSaZiRbOAh9m43Iwkpk4rGAUjCAmlKOWFE4sYHEgt-uI6VyvOG_Lq-peL99-b2ggywhQG_N4fBDQhH_-5lc39-dre-pFc3F7_Xp1e0F6ortG1lX2PqlWGMS26E9g5AyJXxCpwzctX1AXxQrWedZyvPGRcsKK-NYs4HuWyO975TTn9mwGKf05zHutIKwzstpVC8UnxP9TUJZgh2ynHj8l_Lmd3Vbfd121q33dVtdxqx12Blx0fI_50_F70BC4-Dpw</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Li, Juan</creator><creator>Liu, Gui-ping</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20200601</creationdate><title>Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels</title><author>Li, Juan ; Liu, Gui-ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-553c72674900131927baee2349b6eaa9348cfebf65b08b04b10120f6b7960abf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acupuncture</topic><topic>Bone density</topic><topic>Clinical Study</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Osteoporosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Juan</creatorcontrib><creatorcontrib>Liu, Gui-ping</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of acupuncture and tuina science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Juan</au><au>Liu, Gui-ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels</atitle><jtitle>Journal of acupuncture and tuina science</jtitle><stitle>J. Acupunct. Tuina. Sci</stitle><date>2020-06-01</date><risdate>2020</risdate><volume>18</volume><issue>3</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>1672-3597</issn><eissn>1993-0399</eissn><abstract><![CDATA[Objective
To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms.
Methods
A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs. Both groups were treated for 3 months. Before and after treatment, assessed the visual analog scale (VAS) and Oswestry disability index (ODI) scores, determined the bone mineral density of the participants’ lumbar spine (L
2
-L
4
) and left femoral neck, and detected the participants’ serum bone morphogenetic protein-2 (BMP-2) and osteoprotegerin (OPG) levels.
Results
After treatment, the VAS scores of both groups were lower than before treatment (both
P
<0.05), and the VAS score of the observation group was significantly lower than that of the control group (
P
<0.05). After treatment, the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment (both
P
<0.05), and the bone mineral density values of the observation group were higher than those of the control group (
P
<0.05). After treatment, the ODI scores of the two groups were lower than those before treatment (both
P
<0.05), and the ODI score of the observation group was lower than that of the control group
(
P
<0.05). After treatment, the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group (both
P
<0.05).
Conclusion
Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients’ pain, improve dysfunction, and increase bone density, which may be related to the improvement of the serum BMP-2 and OPG levels.]]></abstract><cop>Singapore</cop><pub>Springer Singapore</pub><doi>10.1007/s11726-020-1180-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-3597 |
| ispartof | Journal of acupuncture and tuina science, 2020-06, Vol.18 (3), p.213-218 |
| issn | 1672-3597 1993-0399 |
| language | eng |
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| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); SpringerLink Journals; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | Acupuncture Bone density Clinical Study Medicine Medicine & Public Health Osteoporosis |
| title | Therapeutic effect of heat-sensitive moxibustion plus medications for senile osteoporosis and its effect on serum BMP-2 and OPG levels |
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