Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia
Objective To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action. Methods A total of 70 CI patients meeting the inclusion criteria were divided into an observa...
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| Veröffentlicht in: | Journal of acupuncture and tuina science 2023-08, Vol.21 (4), p.279-284 |
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| container_title | Journal of acupuncture and tuina science |
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| creator | Cao, Yue Hu, Sha Chen, Cheng Wang, Jun Yu, Zhaoan Li, Hongliang Zhong, Feng |
| description | Objective
To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action.
Methods
A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method, with 35 cases in each group. The control group was given estazolam tablets before bedtime, 1 mg/time, once a day. The observation group was treated with additional Yi Nao An Shen acupuncture therapy (acupuncture for benefiting the brain and tranquillization) on the basis of the medication treatment, 4 times a week. After 4 weeks of treatment, the Pittsburgh sleep quality index (PSQI) score, insomnia severity index (ISI) score, pre-sleep arousal scale (PSAS) score, hyperarousal scale (HAS) score, and the change in serum CPT level were compared between the two groups.
Results
During the study, there were 2 dropout cases in the observation group and 1 dropout case in the control group. After treatment, the PSQI, ISI, PSAS, and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment, and the intra-group differences were statistically significant (
P |
| doi_str_mv | 10.1007/s11726-023-1386-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918732330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918732330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c268t-f2b8269d44a544092f26d31ee3faed48e236020d97dade18e1b9a668e5325b613</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhQdRsFZ_gLuA69E8ZjKTpZT6gIIbXYc0ubEpnWRMMkj_vSkjuBIO3Av3nO_Cqapbgu8Jxt1DIqSjvMaU1YT1ZTmrFkQIVmMmxHnZeUdr1orusrpKaY9x23FKF9VxbS3onFCwSIdh6zwYpPQ0Tl7nKQJS3qABjNMqu-BR0e44QlQxTEkdUMoqz6YEcRoKY4QxO4-KxhIBX9jfLu-Q3sXgnS6HFAbv1HV1YdUhwc3vXFYfT-v31Uu9eXt-XT1uak15n2tLtz3lwjSNapsGC2opN4wAMKvAND1QxjHFRnRGGSA9kK1QnPfQMtpuOWHL6m7mjjF8TZCy3Icp-vJSUkH6jlHGcHGR2aVjSCmClWN0g4pHSbA8NSznhmVpWJ4alqcMnTOpeP0nxD_y_6EflkmAUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918732330</pqid></control><display><type>article</type><title>Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>SpringerLink Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Cao, Yue ; Hu, Sha ; Chen, Cheng ; Wang, Jun ; Yu, Zhaoan ; Li, Hongliang ; Zhong, Feng</creator><creatorcontrib>Cao, Yue ; Hu, Sha ; Chen, Cheng ; Wang, Jun ; Yu, Zhaoan ; Li, Hongliang ; Zhong, Feng</creatorcontrib><description>Objective
To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action.
Methods
A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method, with 35 cases in each group. The control group was given estazolam tablets before bedtime, 1 mg/time, once a day. The observation group was treated with additional Yi Nao An Shen acupuncture therapy (acupuncture for benefiting the brain and tranquillization) on the basis of the medication treatment, 4 times a week. After 4 weeks of treatment, the Pittsburgh sleep quality index (PSQI) score, insomnia severity index (ISI) score, pre-sleep arousal scale (PSAS) score, hyperarousal scale (HAS) score, and the change in serum CPT level were compared between the two groups.
Results
During the study, there were 2 dropout cases in the observation group and 1 dropout case in the control group. After treatment, the PSQI, ISI, PSAS, and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment, and the intra-group differences were statistically significant (
P
<0.05). After treatment, changes in each above scale score and the serum CPT level in the observation group were much more significant and were statistically different from those in the control group (
P
<0.05).
Conclusion
Acupuncture plus medication can improve sleep quality, reduce the degree of insomnia, and regulate hyperarousal state in patients with CI, and its mechanism of action may be related to the down-regulation of serum CPT level.</description><identifier>ISSN: 1672-3597</identifier><identifier>EISSN: 1993-0399</identifier><identifier>DOI: 10.1007/s11726-023-1386-0</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Acupuncture ; Insomnia ; Medicine ; Medicine & Public Health ; Sleep ; Special Topic Study</subject><ispartof>Journal of acupuncture and tuina science, 2023-08, Vol.21 (4), p.279-284</ispartof><rights>Shanghai Research Institute of Acupuncture and Meridian 2023</rights><rights>Shanghai Research Institute of Acupuncture and Meridian 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-f2b8269d44a544092f26d31ee3faed48e236020d97dade18e1b9a668e5325b613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11726-023-1386-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918732330?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21368,21369,23236,27903,27904,33509,33682,33723,41467,42536,43638,43766,43784,51297,64361,64365,72215</link.rule.ids></links><search><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>Hu, Sha</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Yu, Zhaoan</creatorcontrib><creatorcontrib>Li, Hongliang</creatorcontrib><creatorcontrib>Zhong, Feng</creatorcontrib><title>Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia</title><title>Journal of acupuncture and tuina science</title><addtitle>J. Acupunct. Tuina. Sci</addtitle><description>Objective
To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action.
Methods
A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method, with 35 cases in each group. The control group was given estazolam tablets before bedtime, 1 mg/time, once a day. The observation group was treated with additional Yi Nao An Shen acupuncture therapy (acupuncture for benefiting the brain and tranquillization) on the basis of the medication treatment, 4 times a week. After 4 weeks of treatment, the Pittsburgh sleep quality index (PSQI) score, insomnia severity index (ISI) score, pre-sleep arousal scale (PSAS) score, hyperarousal scale (HAS) score, and the change in serum CPT level were compared between the two groups.
Results
During the study, there were 2 dropout cases in the observation group and 1 dropout case in the control group. After treatment, the PSQI, ISI, PSAS, and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment, and the intra-group differences were statistically significant (
P
<0.05). After treatment, changes in each above scale score and the serum CPT level in the observation group were much more significant and were statistically different from those in the control group (
P
<0.05).
Conclusion
Acupuncture plus medication can improve sleep quality, reduce the degree of insomnia, and regulate hyperarousal state in patients with CI, and its mechanism of action may be related to the down-regulation of serum CPT level.</description><subject>Acupuncture</subject><subject>Insomnia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Sleep</subject><subject>Special Topic Study</subject><issn>1672-3597</issn><issn>1993-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtLAzEUhQdRsFZ_gLuA69E8ZjKTpZT6gIIbXYc0ubEpnWRMMkj_vSkjuBIO3Av3nO_Cqapbgu8Jxt1DIqSjvMaU1YT1ZTmrFkQIVmMmxHnZeUdr1orusrpKaY9x23FKF9VxbS3onFCwSIdh6zwYpPQ0Tl7nKQJS3qABjNMqu-BR0e44QlQxTEkdUMoqz6YEcRoKY4QxO4-KxhIBX9jfLu-Q3sXgnS6HFAbv1HV1YdUhwc3vXFYfT-v31Uu9eXt-XT1uak15n2tLtz3lwjSNapsGC2opN4wAMKvAND1QxjHFRnRGGSA9kK1QnPfQMtpuOWHL6m7mjjF8TZCy3Icp-vJSUkH6jlHGcHGR2aVjSCmClWN0g4pHSbA8NSznhmVpWJ4alqcMnTOpeP0nxD_y_6EflkmAUA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Cao, Yue</creator><creator>Hu, Sha</creator><creator>Chen, Cheng</creator><creator>Wang, Jun</creator><creator>Yu, Zhaoan</creator><creator>Li, Hongliang</creator><creator>Zhong, Feng</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20230801</creationdate><title>Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia</title><author>Cao, Yue ; Hu, Sha ; Chen, Cheng ; Wang, Jun ; Yu, Zhaoan ; Li, Hongliang ; Zhong, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-f2b8269d44a544092f26d31ee3faed48e236020d97dade18e1b9a668e5325b613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acupuncture</topic><topic>Insomnia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Sleep</topic><topic>Special Topic Study</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>Hu, Sha</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Yu, Zhaoan</creatorcontrib><creatorcontrib>Li, Hongliang</creatorcontrib><creatorcontrib>Zhong, Feng</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of acupuncture and tuina science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Yue</au><au>Hu, Sha</au><au>Chen, Cheng</au><au>Wang, Jun</au><au>Yu, Zhaoan</au><au>Li, Hongliang</au><au>Zhong, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia</atitle><jtitle>Journal of acupuncture and tuina science</jtitle><stitle>J. Acupunct. Tuina. Sci</stitle><date>2023-08-01</date><risdate>2023</risdate><volume>21</volume><issue>4</issue><spage>279</spage><epage>284</epage><pages>279-284</pages><issn>1672-3597</issn><eissn>1993-0399</eissn><abstract>Objective
To observe the effect of combined acupuncture and medication on hyperarousal state and serum copeptin (CPT) in patients with chronic insomnia (CI), and to explore its possible mechanism of action.
Methods
A total of 70 CI patients meeting the inclusion criteria were divided into an observation group and a control group by the random number table method, with 35 cases in each group. The control group was given estazolam tablets before bedtime, 1 mg/time, once a day. The observation group was treated with additional Yi Nao An Shen acupuncture therapy (acupuncture for benefiting the brain and tranquillization) on the basis of the medication treatment, 4 times a week. After 4 weeks of treatment, the Pittsburgh sleep quality index (PSQI) score, insomnia severity index (ISI) score, pre-sleep arousal scale (PSAS) score, hyperarousal scale (HAS) score, and the change in serum CPT level were compared between the two groups.
Results
During the study, there were 2 dropout cases in the observation group and 1 dropout case in the control group. After treatment, the PSQI, ISI, PSAS, and HAS scores and the serum CPT level in both groups decreased compared with the same group before treatment, and the intra-group differences were statistically significant (
P
<0.05). After treatment, changes in each above scale score and the serum CPT level in the observation group were much more significant and were statistically different from those in the control group (
P
<0.05).
Conclusion
Acupuncture plus medication can improve sleep quality, reduce the degree of insomnia, and regulate hyperarousal state in patients with CI, and its mechanism of action may be related to the down-regulation of serum CPT level.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><doi>10.1007/s11726-023-1386-0</doi><tpages>6</tpages></addata></record> |
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| issn | 1672-3597 1993-0399 |
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| subjects | Acupuncture Insomnia Medicine Medicine & Public Health Sleep Special Topic Study |
| title | Effects of combined acupuncture and medication on hyperarousal state and serum copeptin in patients with chronic insomnia |
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