Inhibition of P2X7 Receptor by Extracts of Chinese Medicine
目的：探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02（α-细辛脑）和迷迭香抽提物X0728对人肥大细胞的作用。方法：用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流。结果：40μg／mL SCP01抑制P2X7电流（27．6±2．0）％，而同样浓度的SCP02抑制（29．5±2．2）％（-100mv电位下），笔者还比较了商业用α-细辛脑的效应，42μg／mL可抑制P2X7电流（52．2±2．0）％。相反，40μg／mL X0728激活P2X7电流（28．6±2．8）％，所有这些作用都是电压依赖性的。结论：α-细辛脑对P2X7的抑制将阻滞胞内钙的增加，从而可以解释抑制神经元...
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| Veröffentlicht in: | Journal of acupuncture and tuina science 2008-10, Vol.6 (5), p.286-288 |
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| container_title | Journal of acupuncture and tuina science |
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| creator | Spielmann, Andreas Gu, Quan-bao Ma, Chung-hui Huang, Cheng-gang Xuan, Li-jiang Schwarz, Wolfgang |
| description | 目的：探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02（α-细辛脑）和迷迭香抽提物X0728对人肥大细胞的作用。方法：用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流。结果：40μg／mL SCP01抑制P2X7电流（27．6±2．0）％，而同样浓度的SCP02抑制（29．5±2．2）％（-100mv电位下），笔者还比较了商业用α-细辛脑的效应，42μg／mL可抑制P2X7电流（52．2±2．0）％。相反，40μg／mL X0728激活P2X7电流（28．6±2．8）％，所有这些作用都是电压依赖性的。结论：α-细辛脑对P2X7的抑制将阻滞胞内钙的增加，从而可以解释抑制神经元死亡的原因。而X0728刺激P2X7的药理学效应尚需进一步研究。 |
| doi_str_mv | 10.1007/s11726-008-0286-7 |
| format | Article |
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Acupunct. Tuina. Sci</addtitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><description>目的：探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02（α-细辛脑）和迷迭香抽提物X0728对人肥大细胞的作用。方法：用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流。结果：40μg／mL SCP01抑制P2X7电流（27．6±2．0）％，而同样浓度的SCP02抑制（29．5±2．2）％（-100mv电位下），笔者还比较了商业用α-细辛脑的效应，42μg／mL可抑制P2X7电流（52．2±2．0）％。相反，40μg／mL X0728激活P2X7电流（28．6±2．8）％，所有这些作用都是电压依赖性的。结论：α-细辛脑对P2X7的抑制将阻滞胞内钙的增加，从而可以解释抑制神经元死亡的原因。而X0728刺激P2X7的药理学效应尚需进一步研究。</description><subject>Acupuncture</subject><subject>Basic Study</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>P2X嘌呤受体</subject><subject>石菖蒲</subject><subject>细辛脑</subject><subject>膜片钳技术</subject><subject>迷迭香属</subject><issn>1672-3597</issn><issn>1993-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kF1LwzAUhoMoOKc_wLui19GTpM0HXsmYOpgoouBdSNJ065ztlnTg_r0pHXjn1XnhvB_wIHRJ4IYAiNtIiKAcA0gMVHIsjtCIKMUwMKWOk-aCYlYocYrOYlwBFIJTOkJ3s2ZZ27qr2yZrq-yVforszTu_6dqQ2X02_emCcV3sn5Nl3fjos2df1i7Jc3RSmXX0F4c7Rh8P0_fJE56_PM4m93PsGBCBubGKecuJ47nLbV6YnEgHpWO5KAwxYF1hpS9LZinknBS5l-CtY8awqqyAjdH10LsJ7XbnY6dX7S40aVJTRaSgSpDeRQaXC22MwVd6E-pvE_aagO4Z6YGRTox0z0iLlKFDJiZvs_Dhr_m_0NVhaNk2i23KaWvcV1WvvaayoAmsZL8zgnNJ</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Spielmann, Andreas</creator><creator>Gu, Quan-bao</creator><creator>Ma, Chung-hui</creator><creator>Huang, Cheng-gang</creator><creator>Xuan, Li-jiang</creator><creator>Schwarz, Wolfgang</creator><general>Shanghai Research Institute of Acupuncture and Meridian</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200810</creationdate><title>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</title><author>Spielmann, Andreas ; Gu, Quan-bao ; Ma, Chung-hui ; Huang, Cheng-gang ; Xuan, Li-jiang ; Schwarz, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3017-6ab93eb61c64c4b45a418c0dc3475a1a0bc5b8edd3b2046154e80ebc3aa3fdf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acupuncture</topic><topic>Basic Study</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>P2X嘌呤受体</topic><topic>石菖蒲</topic><topic>细辛脑</topic><topic>膜片钳技术</topic><topic>迷迭香属</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spielmann, Andreas</creatorcontrib><creatorcontrib>Gu, Quan-bao</creatorcontrib><creatorcontrib>Ma, Chung-hui</creatorcontrib><creatorcontrib>Huang, Cheng-gang</creatorcontrib><creatorcontrib>Xuan, Li-jiang</creatorcontrib><creatorcontrib>Schwarz, Wolfgang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of acupuncture and tuina science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spielmann, Andreas</au><au>Gu, Quan-bao</au><au>Ma, Chung-hui</au><au>Huang, Cheng-gang</au><au>Xuan, Li-jiang</au><au>Schwarz, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of P2X7 Receptor by Extracts of Chinese Medicine</atitle><jtitle>Journal of acupuncture and tuina science</jtitle><stitle>J. Acupunct. Tuina. Sci</stitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><date>2008-10</date><risdate>2008</risdate><volume>6</volume><issue>5</issue><spage>286</spage><epage>288</epage><pages>286-288</pages><issn>1672-3597</issn><eissn>1993-0399</eissn><abstract>目的：探讨中草药石菖蒲粗提物SCP01及其纯化物SCP02（α-细辛脑）和迷迭香抽提物X0728对人肥大细胞的作用。方法：用膜片钳技术全细胞记录人肥大细胞膜ATP激活的P2X7受体的电流。结果：40μg／mL SCP01抑制P2X7电流（27．6±2．0）％，而同样浓度的SCP02抑制（29．5±2．2）％（-100mv电位下），笔者还比较了商业用α-细辛脑的效应，42μg／mL可抑制P2X7电流（52．2±2．0）％。相反，40μg／mL X0728激活P2X7电流（28．6±2．8）％，所有这些作用都是电压依赖性的。结论：α-细辛脑对P2X7的抑制将阻滞胞内钙的增加，从而可以解释抑制神经元死亡的原因。而X0728刺激P2X7的药理学效应尚需进一步研究。</abstract><cop>Heidelberg</cop><pub>Shanghai Research Institute of Acupuncture and Meridian</pub><doi>10.1007/s11726-008-0286-7</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acupuncture Basic Study Medicine Medicine & Public Health P2X嘌呤受体 石菖蒲 细辛脑 膜片钳技术 迷迭香属 |
| title | Inhibition of P2X7 Receptor by Extracts of Chinese Medicine |
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