Different Effects and Peripheral Mechanism between Manual-acupuncture and Electroacupuncture on Mast Cell Function and Acupuncture Analgesia by Nerve Block in Acupionts
目的：探讨阻滞穴位神经后针刺对于佐剂型关节炎（AA）大鼠镇痛效应和穴区肥大细胞脱颗粒的影响及进一步了解手针和电针镇痛效应的外周机制差异。方法：以佐剂型关节炎大鼠为炎症痛模型，以足三里为治疗穴位，采用利多卡因预处理（穴位注射2％盐酸利多卡因），将80只大鼠随机分为正常组（Control）、模型组（Model）、利多卡因预处理组（normal＋Lido）、电针组（Electroacupuncture，EA）、利多卡因预处理电针组（Lido＋EA）、犊鼻穴注射利多卡因足三里电针组（DLido＋ZEA）、下巨虚穴注射利多卡因足三里电针组（Xlido＋ZEA）、手针组（Manual Acupunctur...
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| creator | 黄红 詹睿 余晓佳 张迪 李为民 丁光宏 |
| description | 目的：探讨阻滞穴位神经后针刺对于佐剂型关节炎（AA）大鼠镇痛效应和穴区肥大细胞脱颗粒的影响及进一步了解手针和电针镇痛效应的外周机制差异。方法：以佐剂型关节炎大鼠为炎症痛模型，以足三里为治疗穴位，采用利多卡因预处理（穴位注射2％盐酸利多卡因），将80只大鼠随机分为正常组（Control）、模型组（Model）、利多卡因预处理组（normal＋Lido）、电针组（Electroacupuncture，EA）、利多卡因预处理电针组（Lido＋EA）、犊鼻穴注射利多卡因足三里电针组（DLido＋ZEA）、下巨虚穴注射利多卡因足三里电针组（Xlido＋ZEA）、手针组（Manual Acupuncture，MA）、利多卡因预处理手针组（Lido＋MA）及犊鼻穴注射利多卡因足三里手针组（Dlido＋ZMA），每组8只。以大鼠缩爪反射潜伏期及肥大细胞脱颗粒率为观察指标。结果：EA及MA组痛阈都高于M组（P〈0．05或P〈0．01），两组肥大细胞脱颗粒率都明显高于M组（P〈0．01）。说明阻滞针刺穴位或同神经干近心端穴位神经对针刺的镇痛效应有明显的抑制作用，同样的操作在远心端穴位则无影响，神经阻滞对针刺（电针或手针）引起的穴区肥大细胞脱颗粒无明显影响。结论：在手针情况下，针刺镇痛有效神经传导信号在穴位的启动和针感的产生是在肥大细胞脱颗粒之后，它是产生神经信号的直接原因；而对电针情况，电信号是直接刺激神经感受器产生信号启动，肥大细胞脱颗粒成为伴随或反馈效应。 |
| doi_str_mv | 10.1007/s11726-008-0273-z |
| format | Article |
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Acupunct. Tuina. Sci</addtitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><description>目的：探讨阻滞穴位神经后针刺对于佐剂型关节炎（AA）大鼠镇痛效应和穴区肥大细胞脱颗粒的影响及进一步了解手针和电针镇痛效应的外周机制差异。方法：以佐剂型关节炎大鼠为炎症痛模型，以足三里为治疗穴位，采用利多卡因预处理（穴位注射2％盐酸利多卡因），将80只大鼠随机分为正常组（Control）、模型组（Model）、利多卡因预处理组（normal＋Lido）、电针组（Electroacupuncture，EA）、利多卡因预处理电针组（Lido＋EA）、犊鼻穴注射利多卡因足三里电针组（DLido＋ZEA）、下巨虚穴注射利多卡因足三里电针组（Xlido＋ZEA）、手针组（Manual Acupuncture，MA）、利多卡因预处理手针组（Lido＋MA）及犊鼻穴注射利多卡因足三里手针组（Dlido＋ZMA），每组8只。以大鼠缩爪反射潜伏期及肥大细胞脱颗粒率为观察指标。结果：EA及MA组痛阈都高于M组（P〈0．05或P〈0．01），两组肥大细胞脱颗粒率都明显高于M组（P〈0．01）。说明阻滞针刺穴位或同神经干近心端穴位神经对针刺的镇痛效应有明显的抑制作用，同样的操作在远心端穴位则无影响，神经阻滞对针刺（电针或手针）引起的穴区肥大细胞脱颗粒无明显影响。结论：在手针情况下，针刺镇痛有效神经传导信号在穴位的启动和针感的产生是在肥大细胞脱颗粒之后，它是产生神经信号的直接原因；而对电针情况，电信号是直接刺激神经感受器产生信号启动，肥大细胞脱颗粒成为伴随或反馈效应。</description><subject>Acupuncture</subject><subject>Arthritis</subject><subject>Basic Study</subject><subject>Electroacupuncture</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>手捻针</subject><subject>神经阻滞</subject><subject>肥大细胞</subject><subject>针剌镇痛</subject><issn>1672-3597</issn><issn>1993-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctOwzAQRSMEElD4AHYWrA1-NHG8LKUFJF4LWFuOO24Dxil2AqJfxGfi0EqwYuXR1TnjkW6WHVFySgkRZ5FSwQpMSIkJExyvtrI9KiXHhEu5neZCMMxzKXaz_RifCclFwdhe9nVRWwsBfIsmaTBtRNrP0AOEermAoB26BbPQvo6vqIL2A8CjW-077bA23bLzpu0C_DgTl_TQ_I2bHo4tGoNzaNqndYp6ePSHGnnt5hBrjapPdAfhHdC5a8wLqv0Pl5w2HmQ7VrsIh5t3kD1NJ4_jK3xzf3k9Ht1gw_JyhSVn0mpZDQmpzHBmS6GpkIUEm-ayAJrPjKm4rgSjJeEpowCksGJGweTA-SA7We9dhuatg9iq56YL6cKomKSlYHLIZKLomjKhiTGAVctQv-rwqShRfSFqXYhKhai-ELVKDls7MbF-DuF383_S8eajRePnb8lTlTYvtnagWJmz1CLl39-yneA</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>黄红 詹睿 余晓佳 张迪 李为民 丁光宏</creator><general>Shanghai Research Institute of Acupuncture and Meridian</general><general>Springer Nature 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USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of acupuncture and tuina science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>黄红 詹睿 余晓佳 张迪 李为民 丁光宏</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different Effects and Peripheral Mechanism between Manual-acupuncture and Electroacupuncture on Mast Cell Function and Acupuncture Analgesia by Nerve Block in Acupionts</atitle><jtitle>Journal of acupuncture and tuina science</jtitle><stitle>J. Acupunct. Tuina. Sci</stitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><date>2008-10</date><risdate>2008</risdate><volume>6</volume><issue>5</issue><spage>273</spage><epage>275</epage><pages>273-275</pages><issn>1672-3597</issn><eissn>1993-0399</eissn><abstract>目的：探讨阻滞穴位神经后针刺对于佐剂型关节炎（AA）大鼠镇痛效应和穴区肥大细胞脱颗粒的影响及进一步了解手针和电针镇痛效应的外周机制差异。方法：以佐剂型关节炎大鼠为炎症痛模型，以足三里为治疗穴位，采用利多卡因预处理（穴位注射2％盐酸利多卡因），将80只大鼠随机分为正常组（Control）、模型组（Model）、利多卡因预处理组（normal＋Lido）、电针组（Electroacupuncture，EA）、利多卡因预处理电针组（Lido＋EA）、犊鼻穴注射利多卡因足三里电针组（DLido＋ZEA）、下巨虚穴注射利多卡因足三里电针组（Xlido＋ZEA）、手针组（Manual Acupuncture，MA）、利多卡因预处理手针组（Lido＋MA）及犊鼻穴注射利多卡因足三里手针组（Dlido＋ZMA），每组8只。以大鼠缩爪反射潜伏期及肥大细胞脱颗粒率为观察指标。结果：EA及MA组痛阈都高于M组（P〈0．05或P〈0．01），两组肥大细胞脱颗粒率都明显高于M组（P〈0．01）。说明阻滞针刺穴位或同神经干近心端穴位神经对针刺的镇痛效应有明显的抑制作用，同样的操作在远心端穴位则无影响，神经阻滞对针刺（电针或手针）引起的穴区肥大细胞脱颗粒无明显影响。结论：在手针情况下，针刺镇痛有效神经传导信号在穴位的启动和针感的产生是在肥大细胞脱颗粒之后，它是产生神经信号的直接原因；而对电针情况，电信号是直接刺激神经感受器产生信号启动，肥大细胞脱颗粒成为伴随或反馈效应。</abstract><cop>Heidelberg</cop><pub>Shanghai Research Institute of Acupuncture and Meridian</pub><doi>10.1007/s11726-008-0273-z</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of acupuncture and tuina science, 2008-10, Vol.6 (5), p.273-275 |
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| subjects | Acupuncture Arthritis Basic Study Electroacupuncture Medicine Medicine & Public Health 手捻针 神经阻滞 肥大细胞 针剌镇痛 |
| title | Different Effects and Peripheral Mechanism between Manual-acupuncture and Electroacupuncture on Mast Cell Function and Acupuncture Analgesia by Nerve Block in Acupionts |
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