Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture
Objective To investigate the dynamic changes of glycine (Gly) and taurine (Tau) in corpus striatum of rats with ischemia-reperfusion injury (IRI), and the regulation effect of electroacupuncture on them. Methods Thirty SD rats were randomly divided into sham surgery group, model group, and treatment...
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| creator | 徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军 |
| description | Objective
To investigate the dynamic changes of glycine (Gly) and taurine (Tau) in corpus striatum of rats with ischemia-reperfusion injury (IRI), and the regulation effect of electroacupuncture on them.
Methods
Thirty SD rats were randomly divided into sham surgery group, model group, and treatment group. Rats in the sham surgery group were operated without ischemia. Rats in the model group and treatment group were operated to make model of cerebral IRI. The ischemia status lasts 1.5 h, and reperfusion was performed for 3.75 h. Rats in the treatment group were treated with electroacupuncture at Fengchi (GB 20). Neurologic deficit score (NDS) was used to evaluate the rats functions. Microdialysis and High Performance Liquid Chromatography technique were used to detect the changes of Gly and Tau in corpus striatum of rats.
Results
Contents of Gly and Tau increased at 1.5 h after ischemia. Them decreased to level as same as those rats in the sham surgery group after reperfusion. The content of Gly in the model and treatment group increased again at 2–2.5 h after reperfusion, and then decreased to the same level of the sham surgery group. There was a third increase of Gly content in the treatment group at 2.75 h after reperfusion. Electroacupuncture treatment could delay the decrease of Tau content after reperfusion, and make it increase at 1.5, 2 and 2.75 h after reperfusion. The peak appeared in the last time. NDS in the model and treatment group were more than that in the sham surgery group, and lowered at 5.25 h after surgery. Effects in treatment group was better than that in the model group (
P |
| doi_str_mv | 10.1007/s11726-009-0129-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918728814</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>30814621</cqvip_id><sourcerecordid>2918728814</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2101-7f09cad093a3f8efd20b5a35a1eca964941ae776a2367cafc78c1a8af9261f03</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhgdR8PoA7oKuozlJO5kspVYtCIJ2H45p0qa2mTGZIN374Kat4M7V-Rf_5fBV1SWwG2BM3iYAyWvKmKIMuKJwUJ2AUoIyodRh0bXkVAyVPK5OU1oyNpQ15yfV9_0m4NobMlpgmNtEWkceVxvjgyUYZmSKOW61D2TUxi4n8tZHj31eb52v2Cfy5fsFmSSzsGuPNNrORpeTbwOZhGWOm13P2Dlr-l39eFVUbNHkLgfT52jPqyOHq2Qvfu9ZNX0YT0dP9PnlcTK6e6aGAwMqHVMGZ0wJFK6xbsbZ-xDFEMEaVPVADQCtlDVyUUuDzsjGADboFK_BMXFWXe9ru9h-Zpt6vWxzDGVRcwWN5E0Dg-KCvcvENqVone6iX2PcaGB6y1rvWevCWm9ZaygZvs-k4i0Y41_zf6Gr36FFG-afJaff0Xw4v7JasPJKzUH8AE6Ijs0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918728814</pqid></control><display><type>article</type><title>Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>SpringerNature Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><source>ProQuest Central</source><creator>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</creator><creatorcontrib>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</creatorcontrib><description>Objective
To investigate the dynamic changes of glycine (Gly) and taurine (Tau) in corpus striatum of rats with ischemia-reperfusion injury (IRI), and the regulation effect of electroacupuncture on them.
Methods
Thirty SD rats were randomly divided into sham surgery group, model group, and treatment group. Rats in the sham surgery group were operated without ischemia. Rats in the model group and treatment group were operated to make model of cerebral IRI. The ischemia status lasts 1.5 h, and reperfusion was performed for 3.75 h. Rats in the treatment group were treated with electroacupuncture at Fengchi (GB 20). Neurologic deficit score (NDS) was used to evaluate the rats functions. Microdialysis and High Performance Liquid Chromatography technique were used to detect the changes of Gly and Tau in corpus striatum of rats.
Results
Contents of Gly and Tau increased at 1.5 h after ischemia. Them decreased to level as same as those rats in the sham surgery group after reperfusion. The content of Gly in the model and treatment group increased again at 2–2.5 h after reperfusion, and then decreased to the same level of the sham surgery group. There was a third increase of Gly content in the treatment group at 2.75 h after reperfusion. Electroacupuncture treatment could delay the decrease of Tau content after reperfusion, and make it increase at 1.5, 2 and 2.75 h after reperfusion. The peak appeared in the last time. NDS in the model and treatment group were more than that in the sham surgery group, and lowered at 5.25 h after surgery. Effects in treatment group was better than that in the model group (
P
<0.05).
Conclusion
IRI makes contents of Gly and Tau in corpus striatum increase at a special time. Electroacupuncture treatment could increase contents of Gly and Tau at a special time after reperfusion, which maybe an important mechanism of protecting effects of electroacupuncture on the brain.</description><identifier>ISSN: 1672-3597</identifier><identifier>EISSN: 1993-0399</identifier><identifier>DOI: 10.1007/s11726-009-0129-1</identifier><language>eng</language><publisher>Heidelberg: Shanghai Research Institute of Acupuncture and Meridian</publisher><subject>Acupuncture ; Electroacupuncture ; Ischemia ; Medicine ; Medicine & Public Health ; Special Topic for 973 Program ; Surgery ; 再灌注损伤 ; 微透析 ; 牛磺酸 ; 甘氨酸 ; 脑缺血</subject><ispartof>Journal of acupuncture and tuina science, 2009-06, Vol.7 (3), p.129-133</ispartof><rights>Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag GmbH 2009</rights><rights>Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag GmbH 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2101-7f09cad093a3f8efd20b5a35a1eca964941ae776a2367cafc78c1a8af9261f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87251X/87251X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11726-009-0129-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918728814?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,23256,27924,27925,33530,33703,33744,41488,42557,43659,43787,43805,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</creatorcontrib><title>Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture</title><title>Journal of acupuncture and tuina science</title><addtitle>J. Acupunct. Tuina. Sci</addtitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><description>Objective
To investigate the dynamic changes of glycine (Gly) and taurine (Tau) in corpus striatum of rats with ischemia-reperfusion injury (IRI), and the regulation effect of electroacupuncture on them.
Methods
Thirty SD rats were randomly divided into sham surgery group, model group, and treatment group. Rats in the sham surgery group were operated without ischemia. Rats in the model group and treatment group were operated to make model of cerebral IRI. The ischemia status lasts 1.5 h, and reperfusion was performed for 3.75 h. Rats in the treatment group were treated with electroacupuncture at Fengchi (GB 20). Neurologic deficit score (NDS) was used to evaluate the rats functions. Microdialysis and High Performance Liquid Chromatography technique were used to detect the changes of Gly and Tau in corpus striatum of rats.
Results
Contents of Gly and Tau increased at 1.5 h after ischemia. Them decreased to level as same as those rats in the sham surgery group after reperfusion. The content of Gly in the model and treatment group increased again at 2–2.5 h after reperfusion, and then decreased to the same level of the sham surgery group. There was a third increase of Gly content in the treatment group at 2.75 h after reperfusion. Electroacupuncture treatment could delay the decrease of Tau content after reperfusion, and make it increase at 1.5, 2 and 2.75 h after reperfusion. The peak appeared in the last time. NDS in the model and treatment group were more than that in the sham surgery group, and lowered at 5.25 h after surgery. Effects in treatment group was better than that in the model group (
P
<0.05).
Conclusion
IRI makes contents of Gly and Tau in corpus striatum increase at a special time. Electroacupuncture treatment could increase contents of Gly and Tau at a special time after reperfusion, which maybe an important mechanism of protecting effects of electroacupuncture on the brain.</description><subject>Acupuncture</subject><subject>Electroacupuncture</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Special Topic for 973 Program</subject><subject>Surgery</subject><subject>再灌注损伤</subject><subject>微透析</subject><subject>牛磺酸</subject><subject>甘氨酸</subject><subject>脑缺血</subject><issn>1672-3597</issn><issn>1993-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtKAzEUhgdR8PoA7oKuozlJO5kspVYtCIJ2H45p0qa2mTGZIN374Kat4M7V-Rf_5fBV1SWwG2BM3iYAyWvKmKIMuKJwUJ2AUoIyodRh0bXkVAyVPK5OU1oyNpQ15yfV9_0m4NobMlpgmNtEWkceVxvjgyUYZmSKOW61D2TUxi4n8tZHj31eb52v2Cfy5fsFmSSzsGuPNNrORpeTbwOZhGWOm13P2Dlr-l39eFVUbNHkLgfT52jPqyOHq2Qvfu9ZNX0YT0dP9PnlcTK6e6aGAwMqHVMGZ0wJFK6xbsbZ-xDFEMEaVPVADQCtlDVyUUuDzsjGADboFK_BMXFWXe9ru9h-Zpt6vWxzDGVRcwWN5E0Dg-KCvcvENqVone6iX2PcaGB6y1rvWevCWm9ZaygZvs-k4i0Y41_zf6Gr36FFG-afJaff0Xw4v7JasPJKzUH8AE6Ijs0</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</creator><general>Shanghai Research Institute of Acupuncture and Meridian</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20090601</creationdate><title>Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture</title><author>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2101-7f09cad093a3f8efd20b5a35a1eca964941ae776a2367cafc78c1a8af9261f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acupuncture</topic><topic>Electroacupuncture</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Special Topic for 973 Program</topic><topic>Surgery</topic><topic>再灌注损伤</topic><topic>微透析</topic><topic>牛磺酸</topic><topic>甘氨酸</topic><topic>脑缺血</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Journal of acupuncture and tuina science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>徐鸣曙 葛林宝 王新辉 徐佳 王志强 崔毅军</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture</atitle><jtitle>Journal of acupuncture and tuina science</jtitle><stitle>J. Acupunct. Tuina. Sci</stitle><addtitle>Journal of Acupuncture and Tuina Science</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>7</volume><issue>3</issue><spage>129</spage><epage>133</epage><pages>129-133</pages><issn>1672-3597</issn><eissn>1993-0399</eissn><abstract>Objective
To investigate the dynamic changes of glycine (Gly) and taurine (Tau) in corpus striatum of rats with ischemia-reperfusion injury (IRI), and the regulation effect of electroacupuncture on them.
Methods
Thirty SD rats were randomly divided into sham surgery group, model group, and treatment group. Rats in the sham surgery group were operated without ischemia. Rats in the model group and treatment group were operated to make model of cerebral IRI. The ischemia status lasts 1.5 h, and reperfusion was performed for 3.75 h. Rats in the treatment group were treated with electroacupuncture at Fengchi (GB 20). Neurologic deficit score (NDS) was used to evaluate the rats functions. Microdialysis and High Performance Liquid Chromatography technique were used to detect the changes of Gly and Tau in corpus striatum of rats.
Results
Contents of Gly and Tau increased at 1.5 h after ischemia. Them decreased to level as same as those rats in the sham surgery group after reperfusion. The content of Gly in the model and treatment group increased again at 2–2.5 h after reperfusion, and then decreased to the same level of the sham surgery group. There was a third increase of Gly content in the treatment group at 2.75 h after reperfusion. Electroacupuncture treatment could delay the decrease of Tau content after reperfusion, and make it increase at 1.5, 2 and 2.75 h after reperfusion. The peak appeared in the last time. NDS in the model and treatment group were more than that in the sham surgery group, and lowered at 5.25 h after surgery. Effects in treatment group was better than that in the model group (
P
<0.05).
Conclusion
IRI makes contents of Gly and Tau in corpus striatum increase at a special time. Electroacupuncture treatment could increase contents of Gly and Tau at a special time after reperfusion, which maybe an important mechanism of protecting effects of electroacupuncture on the brain.</abstract><cop>Heidelberg</cop><pub>Shanghai Research Institute of Acupuncture and Meridian</pub><doi>10.1007/s11726-009-0129-1</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1672-3597 |
| ispartof | Journal of acupuncture and tuina science, 2009-06, Vol.7 (3), p.129-133 |
| issn | 1672-3597 1993-0399 |
| language | eng |
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| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); SpringerNature Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection; ProQuest Central |
| subjects | Acupuncture Electroacupuncture Ischemia Medicine Medicine & Public Health Special Topic for 973 Program Surgery 再灌注损伤 微透析 牛磺酸 甘氨酸 脑缺血 |
| title | Dynamic Changes of Glycine and Taurine in Corpus Striatum of Rats with Ischemia-reperfusion Injury and Effects of Electroacupuncture |
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