The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials
Introduction The obesity-induced dysregulated expression of adipokines plays a critical role in the onset of obesity-related diseases. A great number of randomized controlled trails demonstrated that exercise could influence the secretion of adipokines. However, the results have been inconsistent. T...
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| Veröffentlicht in: | Sport sciences for health 2017-08, Vol.13 (2), p.303-314 |
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| creator | Lin, Hanxiao Hu, Minling Yan, Yuxia Zhang, Hua |
| description | Introduction
The obesity-induced dysregulated expression of adipokines plays a critical role in the onset of obesity-related diseases. A great number of randomized controlled trails demonstrated that exercise could influence the secretion of adipokines. However, the results have been inconsistent. The aim of the study was to explore the effect of exercise on adipokines’ levels in overweight or obese subjects.
Methods
PubMed, EMBASE and other databases were searched up to January 2016. A total of 21 studies, including 1218 participants, were included in the meta-analysis.
Results
Exercise was statistically associated with an increase in the adiponectin level (WMD 0.67,
P
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| doi_str_mv | 10.1007/s11332-017-0358-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918629153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918629153</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2315-b51312360975fa32d61d563179b4cb99e24a61d3c0514fb8084d0897fc2fed913</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhCMEEqXwANwscTb4J05ibqjiT6rEpZwtJ1m3qdK42GmhPAGPzYYgceLiHdnzjdaTJJecXXPG8pvIuZSCMp5TJlVB1VEy4YVQlAuZHv_olOapZqfJWYxrxlSmlJ4kX4sVEHAOqp54R-ADQtVEIL4jtm62vsOHBnVXkxa2g2xhD20kqPwewjs0yxWigfgSkIu7co1IvCWWbKC31Ha2PcQmDukBY_ym-YSaVL7rg29blH1obBvPkxOHAy5-5zR5fbhfzJ7o_OXxeXY3p5WQXNFScYlfypjOlbNS1BmvVSZ5rsu0KrUGkVq8khVTPHVlwYq0ZoXOXSUc1JrLaXI15m6Df9tB7M3a7wIuGY3QvMjwUBJdfHRVwccYwJltaDY2HAxnZijcjIUbLNwMhRuFjBiZiN5uCeEv-X_oG-NXhGE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918629153</pqid></control><display><type>article</type><title>The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials</title><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Lin, Hanxiao ; Hu, Minling ; Yan, Yuxia ; Zhang, Hua</creator><creatorcontrib>Lin, Hanxiao ; Hu, Minling ; Yan, Yuxia ; Zhang, Hua</creatorcontrib><description><![CDATA[Introduction
The obesity-induced dysregulated expression of adipokines plays a critical role in the onset of obesity-related diseases. A great number of randomized controlled trails demonstrated that exercise could influence the secretion of adipokines. However, the results have been inconsistent. The aim of the study was to explore the effect of exercise on adipokines’ levels in overweight or obese subjects.
Methods
PubMed, EMBASE and other databases were searched up to January 2016. A total of 21 studies, including 1218 participants, were included in the meta-analysis.
Results
Exercise was statistically associated with an increase in the adiponectin level (WMD 0.67,
P
< 0.001) and a reduction in the leptin level (WMD −1.06,
P
< 0.001). Subgroup analyses indicated that a larger change for the adiponectin level was found in Asian subjects (WMD 1.49,
P
< 0.001) and those with diet co-intervention (WMD 0.81,
P
= 0.003), combinative exercise (WMD 0.81,
P
= 0.003) and a training duration >8 weeks (WMD 0.79,
P
= 0.014). For leptin, exercise was more effective in subjects with diet co-intervention (WMD −3.09,
P
< 0.001), aerobic exercise (WMD −3.57,
P
< 0.001), a training duration >8 weeks (WMD −1.55,
P
< 0.001) and a training time ≥60 min per week (WMD −1.14,
P
= 0.005).
Conclusions
These results suggest that an exercise program, with diet co-intervention, can show beneficial effects to ameliorate adipokines dysregulation.]]></description><identifier>ISSN: 1824-7490</identifier><identifier>EISSN: 1825-1234</identifier><identifier>DOI: 10.1007/s11332-017-0358-5</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Chronic illnesses ; Clinical trials ; Diabetes ; Exercise ; Human Physiology ; Inflammation ; Intervention ; Medicine ; Medicine & Public Health ; Meta-analysis ; Metabolic Diseases ; Obesity ; Original Article ; Overweight ; Physical fitness ; Sports Medicine ; White people</subject><ispartof>Sport sciences for health, 2017-08, Vol.13 (2), p.303-314</ispartof><rights>Springer-Verlag Italia 2017</rights><rights>Springer-Verlag Italia 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2315-b51312360975fa32d61d563179b4cb99e24a61d3c0514fb8084d0897fc2fed913</citedby><cites>FETCH-LOGICAL-c2315-b51312360975fa32d61d563179b4cb99e24a61d3c0514fb8084d0897fc2fed913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11332-017-0358-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918629153?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Lin, Hanxiao</creatorcontrib><creatorcontrib>Hu, Minling</creatorcontrib><creatorcontrib>Yan, Yuxia</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><title>The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials</title><title>Sport sciences for health</title><addtitle>Sport Sci Health</addtitle><description><![CDATA[Introduction
The obesity-induced dysregulated expression of adipokines plays a critical role in the onset of obesity-related diseases. A great number of randomized controlled trails demonstrated that exercise could influence the secretion of adipokines. However, the results have been inconsistent. The aim of the study was to explore the effect of exercise on adipokines’ levels in overweight or obese subjects.
Methods
PubMed, EMBASE and other databases were searched up to January 2016. A total of 21 studies, including 1218 participants, were included in the meta-analysis.
Results
Exercise was statistically associated with an increase in the adiponectin level (WMD 0.67,
P
< 0.001) and a reduction in the leptin level (WMD −1.06,
P
< 0.001). Subgroup analyses indicated that a larger change for the adiponectin level was found in Asian subjects (WMD 1.49,
P
< 0.001) and those with diet co-intervention (WMD 0.81,
P
= 0.003), combinative exercise (WMD 0.81,
P
= 0.003) and a training duration >8 weeks (WMD 0.79,
P
= 0.014). For leptin, exercise was more effective in subjects with diet co-intervention (WMD −3.09,
P
< 0.001), aerobic exercise (WMD −3.57,
P
< 0.001), a training duration >8 weeks (WMD −1.55,
P
< 0.001) and a training time ≥60 min per week (WMD −1.14,
P
= 0.005).
Conclusions
These results suggest that an exercise program, with diet co-intervention, can show beneficial effects to ameliorate adipokines dysregulation.]]></description><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Diabetes</subject><subject>Exercise</subject><subject>Human Physiology</subject><subject>Inflammation</subject><subject>Intervention</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Overweight</subject><subject>Physical fitness</subject><subject>Sports Medicine</subject><subject>White people</subject><issn>1824-7490</issn><issn>1825-1234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kM1OwzAQhCMEEqXwANwscTb4J05ibqjiT6rEpZwtJ1m3qdK42GmhPAGPzYYgceLiHdnzjdaTJJecXXPG8pvIuZSCMp5TJlVB1VEy4YVQlAuZHv_olOapZqfJWYxrxlSmlJ4kX4sVEHAOqp54R-ADQtVEIL4jtm62vsOHBnVXkxa2g2xhD20kqPwewjs0yxWigfgSkIu7co1IvCWWbKC31Ha2PcQmDukBY_ym-YSaVL7rg29blH1obBvPkxOHAy5-5zR5fbhfzJ7o_OXxeXY3p5WQXNFScYlfypjOlbNS1BmvVSZ5rsu0KrUGkVq8khVTPHVlwYq0ZoXOXSUc1JrLaXI15m6Df9tB7M3a7wIuGY3QvMjwUBJdfHRVwccYwJltaDY2HAxnZijcjIUbLNwMhRuFjBiZiN5uCeEv-X_oG-NXhGE</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Lin, Hanxiao</creator><creator>Hu, Minling</creator><creator>Yan, Yuxia</creator><creator>Zhang, Hua</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20170801</creationdate><title>The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials</title><author>Lin, Hanxiao ; Hu, Minling ; Yan, Yuxia ; Zhang, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2315-b51312360975fa32d61d563179b4cb99e24a61d3c0514fb8084d0897fc2fed913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chronic illnesses</topic><topic>Clinical trials</topic><topic>Diabetes</topic><topic>Exercise</topic><topic>Human Physiology</topic><topic>Inflammation</topic><topic>Intervention</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Original Article</topic><topic>Overweight</topic><topic>Physical fitness</topic><topic>Sports Medicine</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Hanxiao</creatorcontrib><creatorcontrib>Hu, Minling</creatorcontrib><creatorcontrib>Yan, Yuxia</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Sport sciences for health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Hanxiao</au><au>Hu, Minling</au><au>Yan, Yuxia</au><au>Zhang, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials</atitle><jtitle>Sport sciences for health</jtitle><stitle>Sport Sci Health</stitle><date>2017-08-01</date><risdate>2017</risdate><volume>13</volume><issue>2</issue><spage>303</spage><epage>314</epage><pages>303-314</pages><issn>1824-7490</issn><eissn>1825-1234</eissn><abstract><![CDATA[Introduction
The obesity-induced dysregulated expression of adipokines plays a critical role in the onset of obesity-related diseases. A great number of randomized controlled trails demonstrated that exercise could influence the secretion of adipokines. However, the results have been inconsistent. The aim of the study was to explore the effect of exercise on adipokines’ levels in overweight or obese subjects.
Methods
PubMed, EMBASE and other databases were searched up to January 2016. A total of 21 studies, including 1218 participants, were included in the meta-analysis.
Results
Exercise was statistically associated with an increase in the adiponectin level (WMD 0.67,
P
< 0.001) and a reduction in the leptin level (WMD −1.06,
P
< 0.001). Subgroup analyses indicated that a larger change for the adiponectin level was found in Asian subjects (WMD 1.49,
P
< 0.001) and those with diet co-intervention (WMD 0.81,
P
= 0.003), combinative exercise (WMD 0.81,
P
= 0.003) and a training duration >8 weeks (WMD 0.79,
P
= 0.014). For leptin, exercise was more effective in subjects with diet co-intervention (WMD −3.09,
P
< 0.001), aerobic exercise (WMD −3.57,
P
< 0.001), a training duration >8 weeks (WMD −1.55,
P
< 0.001) and a training time ≥60 min per week (WMD −1.14,
P
= 0.005).
Conclusions
These results suggest that an exercise program, with diet co-intervention, can show beneficial effects to ameliorate adipokines dysregulation.]]></abstract><cop>Milan</cop><pub>Springer Milan</pub><doi>10.1007/s11332-017-0358-5</doi><tpages>12</tpages></addata></record> |
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| subjects | Chronic illnesses Clinical trials Diabetes Exercise Human Physiology Inflammation Intervention Medicine Medicine & Public Health Meta-analysis Metabolic Diseases Obesity Original Article Overweight Physical fitness Sports Medicine White people |
| title | The effect of exercise on adiponectin and leptin levels in overweight or obese subjects: a meta-analysis of randomized controlled trials |
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