A practical access to fluoroalkylthio(seleno)-functionalized bicyclo[1.1.1]pentanes

Rational design of new bioisosteres through introduction of high-value functional groups to bicyclo[1.1.1]pentane (BCP) is of particular use for drug discovery. Disclosed herein is the first access to valuable fluoroalkylthio(seleno)-functionalized BCPs. A range of SCF 3 , SCF 2 H, SCFH 2 , SeCF 3 ,...

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Veröffentlicht in:	Science China. Chemistry 2020-08, Vol.63 (8), p.1025-1029
Hauptverfasser:	Wu, Zhen, Xu, Yaohui, Liu, Jige, Wu, Xinxin, Zhu, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science Chemistry/Food Science Communications Functional groups Metabolism Pentanes Reagents Solvents Substrates
Online-Zugang:	Volltext
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