A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics
Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhe- sion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly（L-lactide） （PLA） and poly（ε-caprolactone） （PCL） with different degradation kinetic...
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| Veröffentlicht in: | Science China. Chemistry 2015-07, Vol.58 (7), p.1159-1168 |
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| creator | Song, Zhiming Shi, Bo Ding, Jianxun Zhuang, Xiuli Zhang, Xiaonan Fu, Changfeng Chen, Xuesi |
| description | Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhe- sion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly（L-lactide） （PLA） and poly（ε-caprolactone） （PCL） with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media （i.e., phosphate-buffered saline） maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histo- pathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson＇s trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL mem- brane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion. |
| doi_str_mv | 10.1007/s11426-015-5425-7 |
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In this work, the electrospun membranes of poly（L-lactide） （PLA） and poly（ε-caprolactone） （PCL） with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media （i.e., phosphate-buffered saline） maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histo- pathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson＇s trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL mem- brane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion.</description><identifier>ISSN: 1674-7291</identifier><identifier>EISSN: 1869-1870</identifier><identifier>DOI: 10.1007/s11426-015-5425-7</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Adhesion tests ; Biocompatibility ; Cell adhesion ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Comparative studies ; Degradation ; Effectiveness ; In vivo methods and tests ; Kinetics ; Membranes ; PCL ; Polycaprolactone ; Polyesters ; Sheaths ; Tendons ; 抗粘连 ; 涤纶 ; 肌腱 ; 降解动力学 ; 静电 ; 预防</subject><ispartof>Science China. Chemistry, 2015-07, Vol.58 (7), p.1159-1168</ispartof><rights>Science China Press and Springer-Verlag Berlin Heidelberg 2015</rights><rights>Science China Press and Springer-Verlag Berlin Heidelberg 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-63873b192f0c58b18a981797161cb7e7478e394fb1723abcba479a0c7646ca263</citedby><cites>FETCH-LOGICAL-c413t-63873b192f0c58b18a981797161cb7e7478e394fb1723abcba479a0c7646ca263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60113X/60113X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11426-015-5425-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918593418?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,21390,21391,23256,27924,27925,33530,33703,33744,34005,34314,41488,42557,43659,43787,43805,43953,44067,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Song, Zhiming</creatorcontrib><creatorcontrib>Shi, Bo</creatorcontrib><creatorcontrib>Ding, Jianxun</creatorcontrib><creatorcontrib>Zhuang, Xiuli</creatorcontrib><creatorcontrib>Zhang, Xiaonan</creatorcontrib><creatorcontrib>Fu, Changfeng</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><title>A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics</title><title>Science China. Chemistry</title><addtitle>Sci. China Chem</addtitle><addtitle>SCIENCE CHINA Chemistry</addtitle><description>Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhe- sion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly（L-lactide） （PLA） and poly（ε-caprolactone） （PCL） with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media （i.e., phosphate-buffered saline） maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histo- pathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson＇s trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL mem- brane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion.</description><subject>Adhesion tests</subject><subject>Biocompatibility</subject><subject>Cell adhesion</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Comparative studies</subject><subject>Degradation</subject><subject>Effectiveness</subject><subject>In vivo methods and tests</subject><subject>Kinetics</subject><subject>Membranes</subject><subject>PCL</subject><subject>Polycaprolactone</subject><subject>Polyesters</subject><subject>Sheaths</subject><subject>Tendons</subject><subject>抗粘连</subject><subject>涤纶</subject><subject>肌腱</subject><subject>降解动力学</subject><subject>静电</subject><subject>预防</subject><issn>1674-7291</issn><issn>1869-1870</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEFP3DAQhSNEJRDlB3Cz2nPAEzse54hQW5CQeoGz5TiT3cCuHWyHan9C_3W92hW9MZeZw_fes19VXQG_Bs7xJgHIRtUc2rqVTVvjSXUOWnU1aOSn5VYoa2w6OKsuU3rhZYTgDbbn1d9b5sJ2ttHm6Z1YysuwY2Fkc6R38nnyKzaHlMNMRyKTH4JndlhTmsqxpD1DG3I5hjQvvvCbHaVMkW1p20frKbE_U16zYRpHisWVDbSKdiiGxeB18pQnl75WX0a7SXR53BfV888fT3f39ePvXw93t4-1kyByrYRG0UPXjNy1ugdtOw3YIShwPRJK1CQ6OfaAjbC9663EznKHSipnGyUuqu8H3zmGt6U81LyEJfoSaUpDuu2EBF0oOFCu_CpFGs0cp62NOwPc7Es3h9JNKd3sSzdYNM1BkwrrVxT_O38m-nYMWge_eiu6jySlWkDBQYl_64mTDA</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Song, Zhiming</creator><creator>Shi, Bo</creator><creator>Ding, Jianxun</creator><creator>Zhuang, Xiuli</creator><creator>Zhang, Xiaonan</creator><creator>Fu, Changfeng</creator><creator>Chen, Xuesi</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20150701</creationdate><title>A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics</title><author>Song, Zhiming ; Shi, Bo ; Ding, Jianxun ; Zhuang, Xiuli ; Zhang, Xiaonan ; Fu, Changfeng ; Chen, Xuesi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-63873b192f0c58b18a981797161cb7e7478e394fb1723abcba479a0c7646ca263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesion tests</topic><topic>Biocompatibility</topic><topic>Cell adhesion</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Comparative studies</topic><topic>Degradation</topic><topic>Effectiveness</topic><topic>In vivo methods and tests</topic><topic>Kinetics</topic><topic>Membranes</topic><topic>PCL</topic><topic>Polycaprolactone</topic><topic>Polyesters</topic><topic>Sheaths</topic><topic>Tendons</topic><topic>抗粘连</topic><topic>涤纶</topic><topic>肌腱</topic><topic>降解动力学</topic><topic>静电</topic><topic>预防</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Zhiming</creatorcontrib><creatorcontrib>Shi, Bo</creatorcontrib><creatorcontrib>Ding, Jianxun</creatorcontrib><creatorcontrib>Zhuang, Xiuli</creatorcontrib><creatorcontrib>Zhang, Xiaonan</creatorcontrib><creatorcontrib>Fu, Changfeng</creatorcontrib><creatorcontrib>Chen, Xuesi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Science China. Chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Zhiming</au><au>Shi, Bo</au><au>Ding, Jianxun</au><au>Zhuang, Xiuli</au><au>Zhang, Xiaonan</au><au>Fu, Changfeng</au><au>Chen, Xuesi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics</atitle><jtitle>Science China. Chemistry</jtitle><stitle>Sci. China Chem</stitle><addtitle>SCIENCE CHINA Chemistry</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>58</volume><issue>7</issue><spage>1159</spage><epage>1168</epage><pages>1159-1168</pages><issn>1674-7291</issn><eissn>1869-1870</eissn><abstract>Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhe- sion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly（L-lactide） （PLA） and poly（ε-caprolactone） （PCL） with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media （i.e., phosphate-buffered saline） maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histo- pathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson＇s trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL mem- brane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion.</abstract><cop>Beijing</cop><pub>Science China Press</pub><doi>10.1007/s11426-015-5425-7</doi><tpages>10</tpages></addata></record> |
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| subjects | Adhesion tests Biocompatibility Cell adhesion Chemistry Chemistry and Materials Science Chemistry/Food Science Comparative studies Degradation Effectiveness In vivo methods and tests Kinetics Membranes PCL Polycaprolactone Polyesters Sheaths Tendons 抗粘连 涤纶 肌腱 降解动力学 静电 预防 |
| title | A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics |
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