Concurrent training is able to increase the activity of adenosine deaminase in platelets in young women

Background Sedentary lifestyle habits are directly related to the increase in the production of reactive oxygen species, to provide a chronic state of oxidative stress. Furthermore, the purinergic system is involved in extracellular signaling and thus influences pathological and physiological processes. Thus, physical exercise is responsible for triggering molecular and tissue changes, to condition the body’s pathophysiological processes, being often suggested as a form of non-pharmacological treatment in different health conditions. Aim To evaluate the effect of physical exercise on markers of oxidative stress and the purinergic system in young adults. Method Sixteen women students, aged between 20 and 40 years, were submitted to the physical exercise protocol, both aerobic and resistance (concurrent training) during the period of eight weeks, making a total of 20 h of training. Results Our findings showed that physical exercise was responsible for increasing the hydrolysis of adenosine diphosphate (ADP) ( p = 0.001) and adenosine deaminase (ADA) ( p = 0.041) in platelets, indicating an increase in ecto-nucleoside triphosphate diphosphohydrolase (ecto-NTPDase) after eight weeks of physical exercise. Furthermore, there was an increase in the concentration of thiobarbituric acid reactive substances (TBARS) ( p = 0.012) and protein thiols (PSH) ( p = 0.004) after one week of exercise. Furthermore, it can be considered that resistance exercise can stimulate the antioxidant defense mechanisms as well as promote an anti-inflammatory and anti-platelet aggregation state. Conclusion In conclusion, physical exercise alters both the mechanisms of oxidative stress and the purinergic system, to have the potential to attenuate inflammatory mechanisms.