Berberine Loaded Tragacanth-Acacia Gum Nanocomplexes: Synthesis, Characterization and Evaluation of In Vitro Anti-inflammatory and Antioxidant Activity
The present study focused on the synthesis and characterization of natural gum-based nanocarrier for the hydrophobic drug, berberine, using acacia and tragacanth gum to improve its antioxidant and anti-inflammatory activity. Berberine loaded tragacanth-acacia gum nanocomplexes were prepared by ionic...
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| Veröffentlicht in: | Journal of cluster science 2023-03, Vol.34 (2), p.747-760 |
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| creator | Bakshi, Jyoti Mehra, Meenakshi Grewal, Sapna Dhingra, Dinesh Kumari, Santosh |
| description | The present study focused on the synthesis and characterization of natural gum-based nanocarrier for the hydrophobic drug, berberine, using acacia and tragacanth gum to improve its antioxidant and anti-inflammatory activity. Berberine loaded tragacanth-acacia gum nanocomplexes were prepared by ionic complexation method and central composite experimental design was applied to optimize nanocomplexes for appropriate particle size and efficient entrapment. The developed nanocomplexes were characterized by dynamic light scattering, Fourier transform-infrared spectroscopy and Transmission electron microscopy. The prepared berberine formulation was assessed for in vitro drug release study, anti-inflammatory and antioxidant activity. The optimized berberine loaded tragacanth-acacia gum nanocomplexes had a particle size of 238.1 nm and entrapment efficiency of 94.8%. TEM observations illustrated spherically shaped nanocomplexes with size in the range of 110–235 nm. Moreover, berberine loaded tragacanth-acacia gum nanocomplexes have controlled released property in vitro and showed enhanced antioxidant and anti-inflammatory potential as indicated by relatively high percentage of scavenging effect (DPPH assay) and Human Red Blood Cell (HRBC) membrane protection over berberine. In conclusion, the ameliorated biological potential of berberine upon encapsulation into gum nanocomplexes indicates that synthesized nanocomplexes can be utilized as an efficient carrier for improving the biological potential of the drug with significant applications in pharmaceutics. |
| doi_str_mv | 10.1007/s10876-022-02252-3 |
| format | Article |
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Berberine loaded tragacanth-acacia gum nanocomplexes were prepared by ionic complexation method and central composite experimental design was applied to optimize nanocomplexes for appropriate particle size and efficient entrapment. The developed nanocomplexes were characterized by dynamic light scattering, Fourier transform-infrared spectroscopy and Transmission electron microscopy. The prepared berberine formulation was assessed for in vitro drug release study, anti-inflammatory and antioxidant activity. The optimized berberine loaded tragacanth-acacia gum nanocomplexes had a particle size of 238.1 nm and entrapment efficiency of 94.8%. TEM observations illustrated spherically shaped nanocomplexes with size in the range of 110–235 nm. Moreover, berberine loaded tragacanth-acacia gum nanocomplexes have controlled released property in vitro and showed enhanced antioxidant and anti-inflammatory potential as indicated by relatively high percentage of scavenging effect (DPPH assay) and Human Red Blood Cell (HRBC) membrane protection over berberine. In conclusion, the ameliorated biological potential of berberine upon encapsulation into gum nanocomplexes indicates that synthesized nanocomplexes can be utilized as an efficient carrier for improving the biological potential of the drug with significant applications in pharmaceutics.</description><identifier>ISSN: 1040-7278</identifier><identifier>EISSN: 1572-8862</identifier><identifier>DOI: 10.1007/s10876-022-02252-3</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acids ; Antioxidants ; Bioavailability ; Biocompatibility ; Catalysis ; Chemistry ; Chemistry and Materials Science ; Design of experiments ; Design optimization ; Drugs ; Efficiency ; Entrapment ; Erythrocytes ; Expected values ; Fourier transforms ; Inorganic Chemistry ; Laboratories ; Nanochemistry ; Nanoparticles ; Original Paper ; Particle size ; Photon correlation spectroscopy ; Physical Chemistry ; Polymers ; Scavenging ; Spectrum analysis ; Surfactants ; Synthesis ; Tragacanth ; Transmission electron microscopy</subject><ispartof>Journal of cluster science, 2023-03, Vol.34 (2), p.747-760</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-9f0d8a7b403ff1c7ea4e05d05748fb5c158625cbe120252b540e37442520c313</citedby><cites>FETCH-LOGICAL-c319t-9f0d8a7b403ff1c7ea4e05d05748fb5c158625cbe120252b540e37442520c313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10876-022-02252-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918303374?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Bakshi, Jyoti</creatorcontrib><creatorcontrib>Mehra, Meenakshi</creatorcontrib><creatorcontrib>Grewal, Sapna</creatorcontrib><creatorcontrib>Dhingra, Dinesh</creatorcontrib><creatorcontrib>Kumari, Santosh</creatorcontrib><title>Berberine Loaded Tragacanth-Acacia Gum Nanocomplexes: Synthesis, Characterization and Evaluation of In Vitro Anti-inflammatory and Antioxidant Activity</title><title>Journal of cluster science</title><addtitle>J Clust Sci</addtitle><description>The present study focused on the synthesis and characterization of natural gum-based nanocarrier for the hydrophobic drug, berberine, using acacia and tragacanth gum to improve its antioxidant and anti-inflammatory activity. Berberine loaded tragacanth-acacia gum nanocomplexes were prepared by ionic complexation method and central composite experimental design was applied to optimize nanocomplexes for appropriate particle size and efficient entrapment. The developed nanocomplexes were characterized by dynamic light scattering, Fourier transform-infrared spectroscopy and Transmission electron microscopy. The prepared berberine formulation was assessed for in vitro drug release study, anti-inflammatory and antioxidant activity. The optimized berberine loaded tragacanth-acacia gum nanocomplexes had a particle size of 238.1 nm and entrapment efficiency of 94.8%. TEM observations illustrated spherically shaped nanocomplexes with size in the range of 110–235 nm. Moreover, berberine loaded tragacanth-acacia gum nanocomplexes have controlled released property in vitro and showed enhanced antioxidant and anti-inflammatory potential as indicated by relatively high percentage of scavenging effect (DPPH assay) and Human Red Blood Cell (HRBC) membrane protection over berberine. In conclusion, the ameliorated biological potential of berberine upon encapsulation into gum nanocomplexes indicates that synthesized nanocomplexes can be utilized as an efficient carrier for improving the biological potential of the drug with significant applications in pharmaceutics.</description><subject>Acids</subject><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Catalysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Design of experiments</subject><subject>Design optimization</subject><subject>Drugs</subject><subject>Efficiency</subject><subject>Entrapment</subject><subject>Erythrocytes</subject><subject>Expected values</subject><subject>Fourier transforms</subject><subject>Inorganic Chemistry</subject><subject>Laboratories</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Particle size</subject><subject>Photon correlation spectroscopy</subject><subject>Physical Chemistry</subject><subject>Polymers</subject><subject>Scavenging</subject><subject>Spectrum analysis</subject><subject>Surfactants</subject><subject>Synthesis</subject><subject>Tragacanth</subject><subject>Transmission electron microscopy</subject><issn>1040-7278</issn><issn>1572-8862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kM1OAyEUhSdGE39fwBWJW9ELzMjUXW3qT9LowsYtucMwiulABWqsL-LrSh0Tdy7IvVy-c244RXHM4IwByPPIoJYXFDjfnIpTsVXssUpyWtcXfDv3UAKVXNa7xX6MrwAwqoXYK76uTGhMsM6QmcfWtGQe8Bk1uvRCxxq1RXKz6sk9Oq99v1yYDxMvyeM6v5to4ymZvGBAnbLHJybrHUHXkuk7LlbD1XfkzpEnm4InY5csta5bYN9j8mH9A2-m_sO2eScZ62TfbVofFjsdLqI5-q0Hxfx6Op_c0tnDzd1kPKNasFGiow7aGmVTgug6pqXB0kDVQiXLumsqzar8_Uo3hnHIsTRVCUbIssw9ZAdxUJwMtsvg31YmJvXqV8HljYqPWC1AZDpTfKB08DEG06llsD2GtWKgNvmrIX-Vs1c_-SuRRWIQxQy7ZxP-rP9RfQMGn4or</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Bakshi, Jyoti</creator><creator>Mehra, Meenakshi</creator><creator>Grewal, Sapna</creator><creator>Dhingra, Dinesh</creator><creator>Kumari, Santosh</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20230301</creationdate><title>Berberine Loaded Tragacanth-Acacia Gum Nanocomplexes: Synthesis, Characterization and Evaluation of In Vitro Anti-inflammatory and Antioxidant Activity</title><author>Bakshi, Jyoti ; Mehra, Meenakshi ; Grewal, Sapna ; Dhingra, Dinesh ; Kumari, Santosh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-9f0d8a7b403ff1c7ea4e05d05748fb5c158625cbe120252b540e37442520c313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Biocompatibility</topic><topic>Catalysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Design of experiments</topic><topic>Design optimization</topic><topic>Drugs</topic><topic>Efficiency</topic><topic>Entrapment</topic><topic>Erythrocytes</topic><topic>Expected values</topic><topic>Fourier transforms</topic><topic>Inorganic Chemistry</topic><topic>Laboratories</topic><topic>Nanochemistry</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Particle size</topic><topic>Photon correlation spectroscopy</topic><topic>Physical Chemistry</topic><topic>Polymers</topic><topic>Scavenging</topic><topic>Spectrum analysis</topic><topic>Surfactants</topic><topic>Synthesis</topic><topic>Tragacanth</topic><topic>Transmission electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakshi, Jyoti</creatorcontrib><creatorcontrib>Mehra, Meenakshi</creatorcontrib><creatorcontrib>Grewal, Sapna</creatorcontrib><creatorcontrib>Dhingra, Dinesh</creatorcontrib><creatorcontrib>Kumari, Santosh</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cluster science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakshi, Jyoti</au><au>Mehra, Meenakshi</au><au>Grewal, Sapna</au><au>Dhingra, Dinesh</au><au>Kumari, Santosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Berberine Loaded Tragacanth-Acacia Gum Nanocomplexes: Synthesis, Characterization and Evaluation of In Vitro Anti-inflammatory and Antioxidant Activity</atitle><jtitle>Journal of cluster science</jtitle><stitle>J Clust Sci</stitle><date>2023-03-01</date><risdate>2023</risdate><volume>34</volume><issue>2</issue><spage>747</spage><epage>760</epage><pages>747-760</pages><issn>1040-7278</issn><eissn>1572-8862</eissn><abstract>The present study focused on the synthesis and characterization of natural gum-based nanocarrier for the hydrophobic drug, berberine, using acacia and tragacanth gum to improve its antioxidant and anti-inflammatory activity. Berberine loaded tragacanth-acacia gum nanocomplexes were prepared by ionic complexation method and central composite experimental design was applied to optimize nanocomplexes for appropriate particle size and efficient entrapment. The developed nanocomplexes were characterized by dynamic light scattering, Fourier transform-infrared spectroscopy and Transmission electron microscopy. The prepared berberine formulation was assessed for in vitro drug release study, anti-inflammatory and antioxidant activity. The optimized berberine loaded tragacanth-acacia gum nanocomplexes had a particle size of 238.1 nm and entrapment efficiency of 94.8%. TEM observations illustrated spherically shaped nanocomplexes with size in the range of 110–235 nm. Moreover, berberine loaded tragacanth-acacia gum nanocomplexes have controlled released property in vitro and showed enhanced antioxidant and anti-inflammatory potential as indicated by relatively high percentage of scavenging effect (DPPH assay) and Human Red Blood Cell (HRBC) membrane protection over berberine. In conclusion, the ameliorated biological potential of berberine upon encapsulation into gum nanocomplexes indicates that synthesized nanocomplexes can be utilized as an efficient carrier for improving the biological potential of the drug with significant applications in pharmaceutics.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10876-022-02252-3</doi><tpages>14</tpages></addata></record> |
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| subjects | Acids Antioxidants Bioavailability Biocompatibility Catalysis Chemistry Chemistry and Materials Science Design of experiments Design optimization Drugs Efficiency Entrapment Erythrocytes Expected values Fourier transforms Inorganic Chemistry Laboratories Nanochemistry Nanoparticles Original Paper Particle size Photon correlation spectroscopy Physical Chemistry Polymers Scavenging Spectrum analysis Surfactants Synthesis Tragacanth Transmission electron microscopy |
| title | Berberine Loaded Tragacanth-Acacia Gum Nanocomplexes: Synthesis, Characterization and Evaluation of In Vitro Anti-inflammatory and Antioxidant Activity |
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