The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study
Decreasing the salivary flow rate manifested by xerostomia occurs early during the irradiation treatment. The duration of depressed salivary function varies among patients. Various histopathological changes occur in the salivary glands. The current study was performed to investigate and compare betw...
Gespeichert in:
| Veröffentlicht in: | Journal of cluster science 2023-03, Vol.34 (2), p.977-989 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 989 |
|---|---|
| container_issue | 2 |
| container_start_page | 977 |
| container_title | Journal of cluster science |
| container_volume | 34 |
| creator | Meabed, Omayma M. Shamaa, Ali Abdelrahman, Ibrahim Y. El-Sayyed, Gharieb S. Mohammed, Saher S. |
| description | Decreasing the salivary flow rate manifested by xerostomia occurs early during the irradiation treatment. The duration of depressed salivary function varies among patients. Various histopathological changes occur in the salivary glands. The current study was performed to investigate and compare between the possible anti-radiotherapeutic effect of the gamma rays-synthesized curcumin nanoparticles (Cur NPs), and chitosan nanoparticles (Cs NPs). They were utilized to overcome the histopathological changes associated with radiation therapy in albino rats’ parotid glands. Sixty adult male Albino rats were utilized, fifteen as control group, fifteen as radiated group and thirty as Cur NPs and Cs NPs treatment groups. The parotid glands were dissected and examined histologically, immunohistochemically for vascular endothelial growth factor (VEGF) as well as histo-morphometrically. The histological results proved the antiradio-therapeutic effect of Cur NPs, and Cs NPs, with the least degenerative changes in the Cur NPs treated group. A high significant increase in VEGF was recorded in the radiated group as compared to the other treated groups. Cs NPs have proved to be an anti-radiotherapeutic and anti-oxidant substrate in treating the histopathological changes in radiated parotid glands of albino rats. However, it was lagging behind Cur NPs in all analyses but non-significant differences between them have been recorded.
Graphical Abstract |
| doi_str_mv | 10.1007/s10876-022-02281-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918302996</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918302996</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-7196331f8fc7341495ac95555a420982a61ab6efcbd0c0d7bfb9a3937a1b5d93</originalsourceid><addsrcrecordid>eNp9UEtLAzEQDqJgrf4BTwHP0Tx2N4m3UmoVior2HrLZxG5pNzXJCvvvTV3BmwPDDMP3GD4Argm-JRjzu0iw4BXClB5bEDScgAkpOUVCVPQ077jAiFMuzsFFjFuMsRSMTcB2vbFw4Zw1CXoHn3Xnkdm0yUfdQd01v5c-mH7fdtB38E03rU62ga86-NQ2cLnLuHhkz3Z12_mMSPEezv3-oINO7ZeF76lvhktw5vQu2qvfOQXrh8V6_ohWL8un-WyFDKtYQpzIijHihDOcFaSQpTayzKULmp-muiK6rqwzdYMNbnjtaqmZZFyTumwkm4KbUfYQ_GdvY1Jb34cuOyoqiWCYymwwBXREmeBjDNapQ2j3OgyKYHWMVI2Rqhyn-olUDZnERlLM4O7Dhj_pf1jfYrR5nw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918302996</pqid></control><display><type>article</type><title>The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central Student</source><source>SpringerNature Journals</source><source>ProQuest Central Korea</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Meabed, Omayma M. ; Shamaa, Ali ; Abdelrahman, Ibrahim Y. ; El-Sayyed, Gharieb S. ; Mohammed, Saher S.</creator><creatorcontrib>Meabed, Omayma M. ; Shamaa, Ali ; Abdelrahman, Ibrahim Y. ; El-Sayyed, Gharieb S. ; Mohammed, Saher S.</creatorcontrib><description>Decreasing the salivary flow rate manifested by xerostomia occurs early during the irradiation treatment. The duration of depressed salivary function varies among patients. Various histopathological changes occur in the salivary glands. The current study was performed to investigate and compare between the possible anti-radiotherapeutic effect of the gamma rays-synthesized curcumin nanoparticles (Cur NPs), and chitosan nanoparticles (Cs NPs). They were utilized to overcome the histopathological changes associated with radiation therapy in albino rats’ parotid glands. Sixty adult male Albino rats were utilized, fifteen as control group, fifteen as radiated group and thirty as Cur NPs and Cs NPs treatment groups. The parotid glands were dissected and examined histologically, immunohistochemically for vascular endothelial growth factor (VEGF) as well as histo-morphometrically. The histological results proved the antiradio-therapeutic effect of Cur NPs, and Cs NPs, with the least degenerative changes in the Cur NPs treated group. A high significant increase in VEGF was recorded in the radiated group as compared to the other treated groups. Cs NPs have proved to be an anti-radiotherapeutic and anti-oxidant substrate in treating the histopathological changes in radiated parotid glands of albino rats. However, it was lagging behind Cur NPs in all analyses but non-significant differences between them have been recorded.
Graphical Abstract</description><identifier>ISSN: 1040-7278</identifier><identifier>EISSN: 1572-8862</identifier><identifier>DOI: 10.1007/s10876-022-02281-y</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Cancer therapies ; Catalysis ; Chemistry ; Chemistry and Materials Science ; Chitosan ; Comparative studies ; Cytokines ; Exocrine glands ; Gamma rays ; Growth factors ; Inorganic Chemistry ; Nanochemistry ; Nanoparticles ; Original Paper ; Oxidative stress ; Oxidizing agents ; Physical Chemistry ; Radiation ; Radiation therapy ; Salivary glands ; Substrates</subject><ispartof>Journal of cluster science, 2023-03, Vol.34 (2), p.977-989</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-7196331f8fc7341495ac95555a420982a61ab6efcbd0c0d7bfb9a3937a1b5d93</citedby><cites>FETCH-LOGICAL-c363t-7196331f8fc7341495ac95555a420982a61ab6efcbd0c0d7bfb9a3937a1b5d93</cites><orcidid>0000-0001-5410-7936 ; 0000-0002-6333-7431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10876-022-02281-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918302996?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,21390,21391,23256,27924,27925,33530,33703,33744,34005,34314,41488,42557,43659,43787,43805,43953,44067,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Meabed, Omayma M.</creatorcontrib><creatorcontrib>Shamaa, Ali</creatorcontrib><creatorcontrib>Abdelrahman, Ibrahim Y.</creatorcontrib><creatorcontrib>El-Sayyed, Gharieb S.</creatorcontrib><creatorcontrib>Mohammed, Saher S.</creatorcontrib><title>The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study</title><title>Journal of cluster science</title><addtitle>J Clust Sci</addtitle><description>Decreasing the salivary flow rate manifested by xerostomia occurs early during the irradiation treatment. The duration of depressed salivary function varies among patients. Various histopathological changes occur in the salivary glands. The current study was performed to investigate and compare between the possible anti-radiotherapeutic effect of the gamma rays-synthesized curcumin nanoparticles (Cur NPs), and chitosan nanoparticles (Cs NPs). They were utilized to overcome the histopathological changes associated with radiation therapy in albino rats’ parotid glands. Sixty adult male Albino rats were utilized, fifteen as control group, fifteen as radiated group and thirty as Cur NPs and Cs NPs treatment groups. The parotid glands were dissected and examined histologically, immunohistochemically for vascular endothelial growth factor (VEGF) as well as histo-morphometrically. The histological results proved the antiradio-therapeutic effect of Cur NPs, and Cs NPs, with the least degenerative changes in the Cur NPs treated group. A high significant increase in VEGF was recorded in the radiated group as compared to the other treated groups. Cs NPs have proved to be an anti-radiotherapeutic and anti-oxidant substrate in treating the histopathological changes in radiated parotid glands of albino rats. However, it was lagging behind Cur NPs in all analyses but non-significant differences between them have been recorded.
Graphical Abstract</description><subject>Animals</subject><subject>Cancer therapies</subject><subject>Catalysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chitosan</subject><subject>Comparative studies</subject><subject>Cytokines</subject><subject>Exocrine glands</subject><subject>Gamma rays</subject><subject>Growth factors</subject><subject>Inorganic Chemistry</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><subject>Oxidizing agents</subject><subject>Physical Chemistry</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Salivary glands</subject><subject>Substrates</subject><issn>1040-7278</issn><issn>1572-8862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UEtLAzEQDqJgrf4BTwHP0Tx2N4m3UmoVior2HrLZxG5pNzXJCvvvTV3BmwPDDMP3GD4Argm-JRjzu0iw4BXClB5bEDScgAkpOUVCVPQ077jAiFMuzsFFjFuMsRSMTcB2vbFw4Zw1CXoHn3Xnkdm0yUfdQd01v5c-mH7fdtB38E03rU62ga86-NQ2cLnLuHhkz3Z12_mMSPEezv3-oINO7ZeF76lvhktw5vQu2qvfOQXrh8V6_ohWL8un-WyFDKtYQpzIijHihDOcFaSQpTayzKULmp-muiK6rqwzdYMNbnjtaqmZZFyTumwkm4KbUfYQ_GdvY1Jb34cuOyoqiWCYymwwBXREmeBjDNapQ2j3OgyKYHWMVI2Rqhyn-olUDZnERlLM4O7Dhj_pf1jfYrR5nw</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Meabed, Omayma M.</creator><creator>Shamaa, Ali</creator><creator>Abdelrahman, Ibrahim Y.</creator><creator>El-Sayyed, Gharieb S.</creator><creator>Mohammed, Saher S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0001-5410-7936</orcidid><orcidid>https://orcid.org/0000-0002-6333-7431</orcidid></search><sort><creationdate>20230301</creationdate><title>The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study</title><author>Meabed, Omayma M. ; Shamaa, Ali ; Abdelrahman, Ibrahim Y. ; El-Sayyed, Gharieb S. ; Mohammed, Saher S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-7196331f8fc7341495ac95555a420982a61ab6efcbd0c0d7bfb9a3937a1b5d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Cancer therapies</topic><topic>Catalysis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chitosan</topic><topic>Comparative studies</topic><topic>Cytokines</topic><topic>Exocrine glands</topic><topic>Gamma rays</topic><topic>Growth factors</topic><topic>Inorganic Chemistry</topic><topic>Nanochemistry</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Oxidative stress</topic><topic>Oxidizing agents</topic><topic>Physical Chemistry</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Salivary glands</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meabed, Omayma M.</creatorcontrib><creatorcontrib>Shamaa, Ali</creatorcontrib><creatorcontrib>Abdelrahman, Ibrahim Y.</creatorcontrib><creatorcontrib>El-Sayyed, Gharieb S.</creatorcontrib><creatorcontrib>Mohammed, Saher S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cluster science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meabed, Omayma M.</au><au>Shamaa, Ali</au><au>Abdelrahman, Ibrahim Y.</au><au>El-Sayyed, Gharieb S.</au><au>Mohammed, Saher S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study</atitle><jtitle>Journal of cluster science</jtitle><stitle>J Clust Sci</stitle><date>2023-03-01</date><risdate>2023</risdate><volume>34</volume><issue>2</issue><spage>977</spage><epage>989</epage><pages>977-989</pages><issn>1040-7278</issn><eissn>1572-8862</eissn><abstract>Decreasing the salivary flow rate manifested by xerostomia occurs early during the irradiation treatment. The duration of depressed salivary function varies among patients. Various histopathological changes occur in the salivary glands. The current study was performed to investigate and compare between the possible anti-radiotherapeutic effect of the gamma rays-synthesized curcumin nanoparticles (Cur NPs), and chitosan nanoparticles (Cs NPs). They were utilized to overcome the histopathological changes associated with radiation therapy in albino rats’ parotid glands. Sixty adult male Albino rats were utilized, fifteen as control group, fifteen as radiated group and thirty as Cur NPs and Cs NPs treatment groups. The parotid glands were dissected and examined histologically, immunohistochemically for vascular endothelial growth factor (VEGF) as well as histo-morphometrically. The histological results proved the antiradio-therapeutic effect of Cur NPs, and Cs NPs, with the least degenerative changes in the Cur NPs treated group. A high significant increase in VEGF was recorded in the radiated group as compared to the other treated groups. Cs NPs have proved to be an anti-radiotherapeutic and anti-oxidant substrate in treating the histopathological changes in radiated parotid glands of albino rats. However, it was lagging behind Cur NPs in all analyses but non-significant differences between them have been recorded.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10876-022-02281-y</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5410-7936</orcidid><orcidid>https://orcid.org/0000-0002-6333-7431</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1040-7278 |
| ispartof | Journal of cluster science, 2023-03, Vol.34 (2), p.977-989 |
| issn | 1040-7278 1572-8862 |
| language | eng |
| recordid | cdi_proquest_journals_2918302996 |
| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); ProQuest Central Student; SpringerNature Journals; ProQuest Central Korea; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | Animals Cancer therapies Catalysis Chemistry Chemistry and Materials Science Chitosan Comparative studies Cytokines Exocrine glands Gamma rays Growth factors Inorganic Chemistry Nanochemistry Nanoparticles Original Paper Oxidative stress Oxidizing agents Physical Chemistry Radiation Radiation therapy Salivary glands Substrates |
| title | The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T04%3A28%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Nano-chitosan%20and%20Nano-curcumin%20on%20Radiated%20Parotid%20Glands%20of%20Albino%20Rats:%20Comparative%20Study&rft.jtitle=Journal%20of%20cluster%20science&rft.au=Meabed,%20Omayma%20M.&rft.date=2023-03-01&rft.volume=34&rft.issue=2&rft.spage=977&rft.epage=989&rft.pages=977-989&rft.issn=1040-7278&rft.eissn=1572-8862&rft_id=info:doi/10.1007/s10876-022-02281-y&rft_dat=%3Cproquest_cross%3E2918302996%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2918302996&rft_id=info:pmid/&rfr_iscdi=true |