Functionalized Gold Nanoparticles Based Optical, Surface Plasmon Resonance-Based Sensor for the Direct Determination of Mitoxantrone Anti-cancer Agent from Real Samples
This study represents a simple and facile method for the fabrication of gold nanoparticles (AuNPs) using Cephradine (Cep) drug as a capping agent. Synthesized Cep-AuNPs have been characterized using different modern analytical techniques such as UV–Vis spectroscopy, X-ray diffractometry, and Atomic...
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| Veröffentlicht in: | Journal of cluster science 2022-01, Vol.33 (1), p.241-247 |
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| creator | Jagirani, Muhammad Saqaf Mahesar, Sarfaraz Ahmed Uddin, Siraj Sherazi, Syed Tufail Hussain Kori, Abdul Hameed Lakho, Saeed Ahmed Kalwar, Nazar Hussain Memon, Safia Sanam |
| description | This study represents a simple and facile method for the fabrication of gold nanoparticles (AuNPs) using Cephradine (Cep) drug as a capping agent. Synthesized Cep-AuNPs have been characterized using different modern analytical techniques such as UV–Vis spectroscopy, X-ray diffractometry, and Atomic Force Microscopy. The estimated average size of synthesized gold nanoparticles was found up to 30 nm. These Cep-AuNPs has been used for the highly selective and sensitive colorimetric sensing for the mitoxantrone (MX) detection. The linear range of proposed colorimetric sensor responded to MX in the range of 10–100 µg/L. The detection and quantification limit of the sensor was 3.5 µg/L and 11.9 µg/L, respectively. The developed sensor was highly selected and highly efficient for MX detection as compared with other coexisting compounds such as 5Florourical, Capecitabine, Methotrexate (MTX), Zoledronic Acid. This developed sensor was successfully applied for the detection of MX from the real biological samples. The developed colorimetric sensor is sensitive, selective, cheaper and no need for sample preparation and easy to operate. No need expansive instruments. |
| doi_str_mv | 10.1007/s10876-020-01948-8 |
| format | Article |
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No need expansive instruments.</description><subject>Anticancer properties</subject><subject>Biological properties</subject><subject>Cancer</subject><subject>Catalysis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Colorimetry</subject><subject>Gold</subject><subject>Inorganic Chemistry</subject><subject>Methotrexate</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Pharmaceuticals</subject><subject>Physical Chemistry</subject><subject>Sensors</subject><subject>Spectrum analysis</subject><subject>Surface plasmon resonance</subject><subject>Synthesis</subject><issn>1040-7278</issn><issn>1572-8862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UcuOFDEMbCGQWBZ-gFMkroTNa7qT47BPpIVFDJwjT-IsvepOmiQjAV_EZ5KhkbhxsGzLVWXL1XUvOXvDGRvOCmd66CkTjDJulKb6UXfCN4OgWvficauZYnQQg37aPSvlgTFmtJQn3a-rQ3R1TBGm8Sd6cp0mTz5ATAvkOroJC3kLpQ3ultbC9JrsDjmAQ_JxgjKnSD5haezokK7AHcaSMgkt6lckF2NGV8kFVszzGOG4i6RA3o81fYdYc4pItrGO1B1FMtneY6wk5DQ3aZjIDualnfG8exJgKvjibz7tvlxdfj6_obd31-_Ot7fUSW4qDT0Mim2C6QN3g_R-A5pB8L1X3vhB7cN-CMEYJZXce8kBUbjeaAegBOuVPO1erbpLTt8OWKp9SIfc3lOsMFxLJvSGNZRYUS6nUjIGu-RxhvzDcmaPjtjVEdscsX8csbqR5EoqDRzvMf-T_g_rNzmXkgA</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Jagirani, Muhammad Saqaf</creator><creator>Mahesar, Sarfaraz Ahmed</creator><creator>Uddin, Siraj</creator><creator>Sherazi, Syed Tufail Hussain</creator><creator>Kori, Abdul Hameed</creator><creator>Lakho, Saeed Ahmed</creator><creator>Kalwar, Nazar Hussain</creator><creator>Memon, Safia Sanam</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20220101</creationdate><title>Functionalized Gold Nanoparticles Based Optical, Surface Plasmon Resonance-Based Sensor for the Direct Determination of Mitoxantrone Anti-cancer Agent from Real Samples</title><author>Jagirani, Muhammad Saqaf ; 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Synthesized Cep-AuNPs have been characterized using different modern analytical techniques such as UV–Vis spectroscopy, X-ray diffractometry, and Atomic Force Microscopy. The estimated average size of synthesized gold nanoparticles was found up to 30 nm. These Cep-AuNPs has been used for the highly selective and sensitive colorimetric sensing for the mitoxantrone (MX) detection. The linear range of proposed colorimetric sensor responded to MX in the range of 10–100 µg/L. The detection and quantification limit of the sensor was 3.5 µg/L and 11.9 µg/L, respectively. The developed sensor was highly selected and highly efficient for MX detection as compared with other coexisting compounds such as 5Florourical, Capecitabine, Methotrexate (MTX), Zoledronic Acid. This developed sensor was successfully applied for the detection of MX from the real biological samples. The developed colorimetric sensor is sensitive, selective, cheaper and no need for sample preparation and easy to operate. No need expansive instruments.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10876-020-01948-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Anticancer properties Biological properties Cancer Catalysis Chemistry Chemistry and Materials Science Colorimetry Gold Inorganic Chemistry Methotrexate Nanochemistry Nanoparticles Original Paper Pharmaceuticals Physical Chemistry Sensors Spectrum analysis Surface plasmon resonance Synthesis |
| title | Functionalized Gold Nanoparticles Based Optical, Surface Plasmon Resonance-Based Sensor for the Direct Determination of Mitoxantrone Anti-cancer Agent from Real Samples |
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