Alginate–zein composite modified with metal organic framework for sulfasalazine delivery
Metal–organic frameworks (MOFs) have promising prospects as drug nanocarriers but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate–zein (SA-ZN) nanocomposites modified metal–organic framework were developed and used...
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| Veröffentlicht in: | Chemical papers 2024, Vol.78 (1), p.565-575 |
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| creator | Asadollahi, Tannaz Moatakef Kazemi, Negar Halajian, Sara |
| description | Metal–organic frameworks (MOFs) have promising prospects as drug nanocarriers but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate–zein (SA-ZN) nanocomposites modified metal–organic framework were developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery and reduced side effects of, thus improving its bioavailability SSZ. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). Based on the results, the Zn
2
(BDC)
2
(DABCO) MOFs were dispersed in biopolymers. In addition, the antibacterial properties of samples have been studied against
Staphylococcus aureus
and
Pseudomonas aeruginosa
. The results showed that the drug-loaded MOF/SA-ZN has a higher antibacterial activity against
S. aureus
gram-positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer-modified MOF-based drug delivery platforms and antibacterial agents. |
| doi_str_mv | 10.1007/s11696-023-03110-w |
| format | Article |
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2
(BDC)
2
(DABCO) MOFs were dispersed in biopolymers. In addition, the antibacterial properties of samples have been studied against
Staphylococcus aureus
and
Pseudomonas aeruginosa
. The results showed that the drug-loaded MOF/SA-ZN has a higher antibacterial activity against
S. aureus
gram-positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer-modified MOF-based drug delivery platforms and antibacterial agents.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-023-03110-w</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Bioavailability ; Biochemistry ; Biocompatibility ; Biomedical materials ; Biopolymers ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Fourier transforms ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Metal-organic frameworks ; Nanocomposites ; Original Paper ; Side effects ; Sodium alginate ; Zein</subject><ispartof>Chemical papers, 2024, Vol.78 (1), p.565-575</ispartof><rights>The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-fda1f03fff87d652dfa0c23baf71d623871da57e049d572749276528ddca0d903</citedby><cites>FETCH-LOGICAL-c319t-fda1f03fff87d652dfa0c23baf71d623871da57e049d572749276528ddca0d903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-023-03110-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-023-03110-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Asadollahi, Tannaz</creatorcontrib><creatorcontrib>Moatakef Kazemi, Negar</creatorcontrib><creatorcontrib>Halajian, Sara</creatorcontrib><title>Alginate–zein composite modified with metal organic framework for sulfasalazine delivery</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>Metal–organic frameworks (MOFs) have promising prospects as drug nanocarriers but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate–zein (SA-ZN) nanocomposites modified metal–organic framework were developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery and reduced side effects of, thus improving its bioavailability SSZ. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). Based on the results, the Zn
2
(BDC)
2
(DABCO) MOFs were dispersed in biopolymers. In addition, the antibacterial properties of samples have been studied against
Staphylococcus aureus
and
Pseudomonas aeruginosa
. The results showed that the drug-loaded MOF/SA-ZN has a higher antibacterial activity against
S. aureus
gram-positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer-modified MOF-based drug delivery platforms and antibacterial agents.</description><subject>Bioavailability</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biopolymers</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Fourier transforms</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Metal-organic frameworks</subject><subject>Nanocomposites</subject><subject>Original Paper</subject><subject>Side effects</subject><subject>Sodium alginate</subject><subject>Zein</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAYRS0EEqXwAkyWmA2f7cROxqriT6rEAguLZWK7uCRxsVOiduIdeEOehECQ2Jjucu690kHolMI5BZAXiVJRCgKME-CUAun30IRyLkgJMt9HE-BCEMFzdoiOUloBZBnkMEGPs3rpW93Zz_ePnfUtrkKzDsl3FjfBeOetwb3vnnFjO13jEJe69RV2UTe2D_EFuxBx2tROJ13rnW8tNrb2bzZuj9GB03WyJ785RQ9Xl_fzG7K4u76dzxak4rTsiDOaOuDOuUIakTPjNFSMP2knqRGMF0PoXFrISpNLJrOSyQErjKk0mBL4FJ2Nu-sYXjc2dWoVNrEdLhUracFylnE2UGykqhhSitapdfSNjltFQX07VKNDNThUPw5VP5T4WEoD3C5t_Jv-p_UFXdB3eA</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Asadollahi, Tannaz</creator><creator>Moatakef Kazemi, Negar</creator><creator>Halajian, Sara</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>2024</creationdate><title>Alginate–zein composite modified with metal organic framework for sulfasalazine delivery</title><author>Asadollahi, Tannaz ; Moatakef Kazemi, Negar ; Halajian, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-fda1f03fff87d652dfa0c23baf71d623871da57e049d572749276528ddca0d903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bioavailability</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biopolymers</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Fourier transforms</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Metal-organic frameworks</topic><topic>Nanocomposites</topic><topic>Original Paper</topic><topic>Side effects</topic><topic>Sodium alginate</topic><topic>Zein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asadollahi, Tannaz</creatorcontrib><creatorcontrib>Moatakef Kazemi, Negar</creatorcontrib><creatorcontrib>Halajian, Sara</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asadollahi, Tannaz</au><au>Moatakef Kazemi, Negar</au><au>Halajian, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alginate–zein composite modified with metal organic framework for sulfasalazine delivery</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2024</date><risdate>2024</risdate><volume>78</volume><issue>1</issue><spage>565</spage><epage>575</epage><pages>565-575</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>Metal–organic frameworks (MOFs) have promising prospects as drug nanocarriers but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate–zein (SA-ZN) nanocomposites modified metal–organic framework were developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery and reduced side effects of, thus improving its bioavailability SSZ. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). Based on the results, the Zn
2
(BDC)
2
(DABCO) MOFs were dispersed in biopolymers. In addition, the antibacterial properties of samples have been studied against
Staphylococcus aureus
and
Pseudomonas aeruginosa
. The results showed that the drug-loaded MOF/SA-ZN has a higher antibacterial activity against
S. aureus
gram-positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer-modified MOF-based drug delivery platforms and antibacterial agents.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-023-03110-w</doi><tpages>11</tpages></addata></record> |
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| subjects | Bioavailability Biochemistry Biocompatibility Biomedical materials Biopolymers Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Fourier transforms Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Metal-organic frameworks Nanocomposites Original Paper Side effects Sodium alginate Zein |
| title | Alginate–zein composite modified with metal organic framework for sulfasalazine delivery |
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