Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots
The wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu 2 ZnSnS 4 quantum dots (CZTS QDs) to prevent i...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2023-10, Vol.80 (10), p.11273-11293 |
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| creator | Ceylan, Seda Küçükosman, Rıdvan Yurt, Fatma Özel, Derya Öztürk, İsmail Demir, Didem Ocakoglu, Kasim |
| description | The wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu
2
ZnSnS
4
quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV–Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing. |
| doi_str_mv | 10.1007/s00289-022-04615-2 |
| format | Article |
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2
ZnSnS
4
quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV–Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-022-04615-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Absorption spectroscopy ; Antimicrobial agents ; Biocompatibility ; Breeding grounds ; Cell culture ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chitosan ; Complex Fluids and Microfluidics ; Contact angle ; Copper ; E coli ; Ethanol ; Glycerol ; Heat resistance ; Investigations ; Mechanical properties ; Membranes ; Metal oxides ; Microorganisms ; Morphology ; Nanoparticles ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Polymer Sciences ; Polymers ; Polyvinyl alcohol ; Quantum dots ; Soft and Granular Matter ; Solvents ; Tissue engineering ; Wound healing ; Zinc</subject><ispartof>Polymer bulletin (Berlin, Germany), 2023-10, Vol.80 (10), p.11273-11293</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-285ea80a9bbd94ccd54cc55ccafe90b1b0fa678b33aa220a8c369872608765603</citedby><cites>FETCH-LOGICAL-c319t-285ea80a9bbd94ccd54cc55ccafe90b1b0fa678b33aa220a8c369872608765603</cites><orcidid>0000-0002-1088-7886</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-022-04615-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918136626?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Ceylan, Seda</creatorcontrib><creatorcontrib>Küçükosman, Rıdvan</creatorcontrib><creatorcontrib>Yurt, Fatma</creatorcontrib><creatorcontrib>Özel, Derya</creatorcontrib><creatorcontrib>Öztürk, İsmail</creatorcontrib><creatorcontrib>Demir, Didem</creatorcontrib><creatorcontrib>Ocakoglu, Kasim</creatorcontrib><title>Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>The wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu
2
ZnSnS
4
quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV–Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.</description><subject>Absorption spectroscopy</subject><subject>Antimicrobial agents</subject><subject>Biocompatibility</subject><subject>Breeding grounds</subject><subject>Cell culture</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chitosan</subject><subject>Complex Fluids and Microfluidics</subject><subject>Contact angle</subject><subject>Copper</subject><subject>E coli</subject><subject>Ethanol</subject><subject>Glycerol</subject><subject>Heat resistance</subject><subject>Investigations</subject><subject>Mechanical properties</subject><subject>Membranes</subject><subject>Metal oxides</subject><subject>Microorganisms</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>Quantum dots</subject><subject>Soft and Granular Matter</subject><subject>Solvents</subject><subject>Tissue engineering</subject><subject>Wound healing</subject><subject>Zinc</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1LAzEQhoMoWKt_wFPA89pJsptNjqX4BQUFqwcvIZvNuindbN2kSv-9qSt48zLDwPPOMA9ClwSuCUA5CwBUyAwozSDnpMjoEZqQnPGM5rk8RhMgJWQgmDxFZyGsIc2ckwlScx9d58zQV05vsDbRfbq4x9a32hvbWR9x3-Cn1_nMtC72QXvcuE0X8JeLLY6txbquXUrZA7d4Wz3jj532cdfhuo_hHJ00ehPsxW-fopfbm9XiPls-3j0s5svMMCJjRkVhtQAtq6qWuTF1kUpRGKMbK6EiFTSal6JiTGtKQQvDuBQl5SBKXnBgU3Q17t0O_cfOhqjW_W7w6aSikgjCOKc8UXSk0r8hDLZR28F1etgrAuogUo0iVRKpfkQqmkJsDIUE-3c7_K3-J_UNGuB2Ug</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Ceylan, Seda</creator><creator>Küçükosman, Rıdvan</creator><creator>Yurt, Fatma</creator><creator>Özel, Derya</creator><creator>Öztürk, İsmail</creator><creator>Demir, Didem</creator><creator>Ocakoglu, Kasim</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-1088-7886</orcidid></search><sort><creationdate>20231001</creationdate><title>Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots</title><author>Ceylan, Seda ; Küçükosman, Rıdvan ; Yurt, Fatma ; Özel, Derya ; Öztürk, İsmail ; Demir, Didem ; Ocakoglu, Kasim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-285ea80a9bbd94ccd54cc55ccafe90b1b0fa678b33aa220a8c369872608765603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorption spectroscopy</topic><topic>Antimicrobial agents</topic><topic>Biocompatibility</topic><topic>Breeding grounds</topic><topic>Cell culture</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chitosan</topic><topic>Complex Fluids and Microfluidics</topic><topic>Contact angle</topic><topic>Copper</topic><topic>E coli</topic><topic>Ethanol</topic><topic>Glycerol</topic><topic>Heat resistance</topic><topic>Investigations</topic><topic>Mechanical properties</topic><topic>Membranes</topic><topic>Metal oxides</topic><topic>Microorganisms</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Polyvinyl alcohol</topic><topic>Quantum dots</topic><topic>Soft and Granular Matter</topic><topic>Solvents</topic><topic>Tissue engineering</topic><topic>Wound healing</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceylan, Seda</creatorcontrib><creatorcontrib>Küçükosman, Rıdvan</creatorcontrib><creatorcontrib>Yurt, Fatma</creatorcontrib><creatorcontrib>Özel, Derya</creatorcontrib><creatorcontrib>Öztürk, İsmail</creatorcontrib><creatorcontrib>Demir, Didem</creatorcontrib><creatorcontrib>Ocakoglu, Kasim</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceylan, Seda</au><au>Küçükosman, Rıdvan</au><au>Yurt, Fatma</au><au>Özel, Derya</au><au>Öztürk, İsmail</au><au>Demir, Didem</au><au>Ocakoglu, Kasim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2023-10-01</date><risdate>2023</risdate><volume>80</volume><issue>10</issue><spage>11273</spage><epage>11293</epage><pages>11273-11293</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>The wound environment is a breeding ground for pathogens, and traditional wound dressing materials lack antibacterial properties. In this work, we aimed to develop PVA/chitosan (P/C)-based wound dressing scaffolds with anti-infective properties using Cu
2
ZnSnS
4
quantum dots (CZTS QDs) to prevent infections in the wound. CZTS quantum dots were prepared by a simple hydrothermal process and characterized using appropriate techniques such as TEM, XRD, FTIR spectrum, and UV–Vis absorption spectroscopy. CZTS QDs were subsequently loaded at different concentrations onto PVA/chitosan membranes (0, 1.6, 2.5 and 3.3% w/w, based on the total polymer quantity). The chemical structure, contact angle and mechanical properties of the membranes were analyzed, and their antimicrobial activities and cell viability were also investigated. The cytocompatibility of the membranes and cell morphology was investigated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM. Based on studies on the interactions between membranes and cells, it was determined that incorporation of CZTS QDs into the membrane did not cause toxicity. To the best of our knowledge, this is the first report on loading CZTS QDs into membranes for tissue engineering applications, and the overall findings suggest that CZTS QDs-integrated membranes might have potentially appealing uses as antimicrobial films for wound healing.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-022-04615-2</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0002-1088-7886</orcidid></addata></record> |
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| ispartof | Polymer bulletin (Berlin, Germany), 2023-10, Vol.80 (10), p.11273-11293 |
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| subjects | Absorption spectroscopy Antimicrobial agents Biocompatibility Breeding grounds Cell culture Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chitosan Complex Fluids and Microfluidics Contact angle Copper E coli Ethanol Glycerol Heat resistance Investigations Mechanical properties Membranes Metal oxides Microorganisms Morphology Nanoparticles Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Polymers Polyvinyl alcohol Quantum dots Soft and Granular Matter Solvents Tissue engineering Wound healing Zinc |
| title | Antimicrobial activity enhancement of PVA/chitosan films with the additive of CZTS quantum dots |
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