Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism
Patients with hypothyroidism always suffer from neuropsychiatric symptoms such as lack of concentration, anxiety, and depression. Recent studies show that the glutamatergic system is the key part to neuropsychiatric accommodation, although the fundamental process of the dysfunction is not well under...
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| Veröffentlicht in: | Applied magnetic resonance 2014, Vol.45 (1), p.83-92 |
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| creator | Gong, Yan Bai, Zhilan Liu, Xinxin Zhang, Qiujuan Wang, Shejiao Liu, Feng Dai, Xiaoqing |
| description | Patients with hypothyroidism always suffer from neuropsychiatric symptoms such as lack of concentration, anxiety, and depression. Recent studies show that the glutamatergic system is the key part to neuropsychiatric accommodation, although the fundamental process of the dysfunction is not well understood. Therefore, our study is devoted to investigate the change of brain metabolisms by focusing on glutamate concentration in patients with hypothyroidism. Using proton magnetic resonance spectroscopy, we try to find out the possible correlation between hypothyroidism and glutamatergic system. Twenty-one untreated hypothyroidism patients and 21 age- and gender-matched controls were included in this study. Posterior cingulate cortex is the region of interest and was examined by magnetic resonance spectroscopy with a technique referred as TE-averaged PRESS at 3T field strength. The intensity of glutamate, choline,
N
-acetylaspartate and creatine was assessed utilizing jMRUI v4.0 software. Hypothyroid patients showed an increase of glutamate (
p
= 0.013) and choline (
p
= 0.01) in the posterior cingulate cortex compared with controls. Signal intensity of glutamate and choline increased in the region of the posterior cingulate cortex in patients with hypothyroidism. This change indicated a potential role of glutamate in the brain dysfunction in hypothyroidism, and a possible immunological mechanisms effect on Cho’s level. |
| doi_str_mv | 10.1007/s00723-013-0500-8 |
| format | Article |
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N
-acetylaspartate and creatine was assessed utilizing jMRUI v4.0 software. Hypothyroid patients showed an increase of glutamate (
p
= 0.013) and choline (
p
= 0.01) in the posterior cingulate cortex compared with controls. Signal intensity of glutamate and choline increased in the region of the posterior cingulate cortex in patients with hypothyroidism. This change indicated a potential role of glutamate in the brain dysfunction in hypothyroidism, and a possible immunological mechanisms effect on Cho’s level.</description><identifier>ISSN: 0937-9347</identifier><identifier>EISSN: 1613-7507</identifier><identifier>DOI: 10.1007/s00723-013-0500-8</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Atoms and Molecules in Strong Fields ; Brain ; Choline ; Creatine ; Emotional disorders ; Field strength ; Hormones ; Hypothyroidism ; Immunology ; Laser Matter Interaction ; Localization ; Magnetic resonance spectroscopy ; Metabolism ; Metabolites ; Mood disorders ; Organic Chemistry ; Physical Chemistry ; Physics ; Physics and Astronomy ; Proton magnetic resonance ; Software ; Solid State Physics ; Spectroscopy/Spectrometry ; Spectrum analysis ; Thyroid gland</subject><ispartof>Applied magnetic resonance, 2014, Vol.45 (1), p.83-92</ispartof><rights>Springer-Verlag Wien 2013</rights><rights>Springer-Verlag Wien 2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-fa8d704ba82f169ecdd45307378fd9b19da3a05212fa8fabbe56e4697ef89aaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00723-013-0500-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918135310?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Bai, Zhilan</creatorcontrib><creatorcontrib>Liu, Xinxin</creatorcontrib><creatorcontrib>Zhang, Qiujuan</creatorcontrib><creatorcontrib>Wang, Shejiao</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Dai, Xiaoqing</creatorcontrib><title>Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism</title><title>Applied magnetic resonance</title><addtitle>Appl Magn Reson</addtitle><description>Patients with hypothyroidism always suffer from neuropsychiatric symptoms such as lack of concentration, anxiety, and depression. Recent studies show that the glutamatergic system is the key part to neuropsychiatric accommodation, although the fundamental process of the dysfunction is not well understood. Therefore, our study is devoted to investigate the change of brain metabolisms by focusing on glutamate concentration in patients with hypothyroidism. Using proton magnetic resonance spectroscopy, we try to find out the possible correlation between hypothyroidism and glutamatergic system. Twenty-one untreated hypothyroidism patients and 21 age- and gender-matched controls were included in this study. Posterior cingulate cortex is the region of interest and was examined by magnetic resonance spectroscopy with a technique referred as TE-averaged PRESS at 3T field strength. The intensity of glutamate, choline,
N
-acetylaspartate and creatine was assessed utilizing jMRUI v4.0 software. Hypothyroid patients showed an increase of glutamate (
p
= 0.013) and choline (
p
= 0.01) in the posterior cingulate cortex compared with controls. Signal intensity of glutamate and choline increased in the region of the posterior cingulate cortex in patients with hypothyroidism. This change indicated a potential role of glutamate in the brain dysfunction in hypothyroidism, and a possible immunological mechanisms effect on Cho’s level.</description><subject>Atoms and Molecules in Strong Fields</subject><subject>Brain</subject><subject>Choline</subject><subject>Creatine</subject><subject>Emotional disorders</subject><subject>Field strength</subject><subject>Hormones</subject><subject>Hypothyroidism</subject><subject>Immunology</subject><subject>Laser Matter Interaction</subject><subject>Localization</subject><subject>Magnetic resonance spectroscopy</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mood disorders</subject><subject>Organic Chemistry</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Proton magnetic resonance</subject><subject>Software</subject><subject>Solid State Physics</subject><subject>Spectroscopy/Spectrometry</subject><subject>Spectrum analysis</subject><subject>Thyroid gland</subject><issn>0937-9347</issn><issn>1613-7507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kF1LwzAUhoMoOKc_wLuA19WkaZv0UoZugw3Fj-uQtidbRpd0SXvRf29GBa-8OF_wPuccXoTuKXmkhPCnEFPKEkJj5IQk4gLNaBEnnhN-iWakZDwpWcav0U0IB0JoLiifodPa1h5UgAa_u9CDN87jhbG7oVU94GU79Op47pRt8GLvWmMBbyMw-IhUI96qnYXe1PgDgrPK1oA_O6h770LtuhEbi1dj5_r96J1pTDjeoiut2gB3v3WOvl9fvharZPO2XC-eN0mdFqJPtBINJ1mlRKppUULdNFnOCGdc6KasaNkopkie0jQqtaoqyAvIipKDFqVSms3Rw7S38-40QOjlwQ3expMyLamgLGeURBWdVHV8OHjQsvPmqPwoKZFnZ-XkrIzOyrOzUkQmnZgQtXYH_m_z_9APKex-BQ</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Gong, Yan</creator><creator>Bai, Zhilan</creator><creator>Liu, Xinxin</creator><creator>Zhang, Qiujuan</creator><creator>Wang, Shejiao</creator><creator>Liu, Feng</creator><creator>Dai, Xiaoqing</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>2014</creationdate><title>Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism</title><author>Gong, Yan ; Bai, Zhilan ; Liu, Xinxin ; Zhang, Qiujuan ; Wang, Shejiao ; Liu, Feng ; Dai, Xiaoqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-fa8d704ba82f169ecdd45307378fd9b19da3a05212fa8fabbe56e4697ef89aaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Atoms and Molecules in Strong Fields</topic><topic>Brain</topic><topic>Choline</topic><topic>Creatine</topic><topic>Emotional disorders</topic><topic>Field strength</topic><topic>Hormones</topic><topic>Hypothyroidism</topic><topic>Immunology</topic><topic>Laser Matter Interaction</topic><topic>Localization</topic><topic>Magnetic resonance spectroscopy</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Mood disorders</topic><topic>Organic Chemistry</topic><topic>Physical Chemistry</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Proton magnetic resonance</topic><topic>Software</topic><topic>Solid State Physics</topic><topic>Spectroscopy/Spectrometry</topic><topic>Spectrum analysis</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Bai, Zhilan</creatorcontrib><creatorcontrib>Liu, Xinxin</creatorcontrib><creatorcontrib>Zhang, Qiujuan</creatorcontrib><creatorcontrib>Wang, Shejiao</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Dai, Xiaoqing</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Materials Science Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Applied magnetic resonance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Yan</au><au>Bai, Zhilan</au><au>Liu, Xinxin</au><au>Zhang, Qiujuan</au><au>Wang, Shejiao</au><au>Liu, Feng</au><au>Dai, Xiaoqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism</atitle><jtitle>Applied magnetic resonance</jtitle><stitle>Appl Magn Reson</stitle><date>2014</date><risdate>2014</risdate><volume>45</volume><issue>1</issue><spage>83</spage><epage>92</epage><pages>83-92</pages><issn>0937-9347</issn><eissn>1613-7507</eissn><abstract>Patients with hypothyroidism always suffer from neuropsychiatric symptoms such as lack of concentration, anxiety, and depression. Recent studies show that the glutamatergic system is the key part to neuropsychiatric accommodation, although the fundamental process of the dysfunction is not well understood. Therefore, our study is devoted to investigate the change of brain metabolisms by focusing on glutamate concentration in patients with hypothyroidism. Using proton magnetic resonance spectroscopy, we try to find out the possible correlation between hypothyroidism and glutamatergic system. Twenty-one untreated hypothyroidism patients and 21 age- and gender-matched controls were included in this study. Posterior cingulate cortex is the region of interest and was examined by magnetic resonance spectroscopy with a technique referred as TE-averaged PRESS at 3T field strength. The intensity of glutamate, choline,
N
-acetylaspartate and creatine was assessed utilizing jMRUI v4.0 software. Hypothyroid patients showed an increase of glutamate (
p
= 0.013) and choline (
p
= 0.01) in the posterior cingulate cortex compared with controls. Signal intensity of glutamate and choline increased in the region of the posterior cingulate cortex in patients with hypothyroidism. This change indicated a potential role of glutamate in the brain dysfunction in hypothyroidism, and a possible immunological mechanisms effect on Cho’s level.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00723-013-0500-8</doi><tpages>10</tpages></addata></record> |
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| subjects | Atoms and Molecules in Strong Fields Brain Choline Creatine Emotional disorders Field strength Hormones Hypothyroidism Immunology Laser Matter Interaction Localization Magnetic resonance spectroscopy Metabolism Metabolites Mood disorders Organic Chemistry Physical Chemistry Physics Physics and Astronomy Proton magnetic resonance Software Solid State Physics Spectroscopy/Spectrometry Spectrum analysis Thyroid gland |
| title | Increased Posterior Cingulate Glutamate and Choline Measured by Magnetic Resonance Spectroscopy in Hypothyroidism |
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