Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior
Oligoaniline (OANI) was prepared using chemical oxidative method using ascorbic acid as a dopant and ammonium persulfate as an oxidant. As-synthesized OANI was subjected for the preparation of various drug composites. All the synthesized compounds were characterized by FTIR, 1 HNMR, TGA, GPC, etc. T...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2019-05, Vol.76 (5), p.2439-2451 |
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| container_title | Polymer bulletin (Berlin, Germany) |
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| creator | Kashyap, Gunjan Meghwal, Kiran Ameta, Chetna Ameta, Rakshit Punjabi, Pinki B. |
| description | Oligoaniline (OANI) was prepared using chemical oxidative method using ascorbic acid as a dopant and ammonium persulfate as an oxidant. As-synthesized OANI was subjected for the preparation of various drug composites. All the synthesized compounds were characterized by FTIR,
1
HNMR, TGA, GPC, etc. The thermal stability of the compounds was determined by TGA. The molecular weight was determined by GPC. Antibacterial studies of the synthesized compounds were investigated against four Gram-positive (
Staphylococcus aureus
MTCC 96,
Streptococcus pyogenes
MTCC 442,
B
.
subtilis
MTCC 441 and
S. mutans
MTCC 890) and four Gram-negative (
Escherichia coli
MTCC 443,
Pseudomonas aeruginosa
MTCC 1688,
KL. pneumoniae
MTCC 109 and
S. typhi
MTCC 98) bacteria based on their clinical and pharmacological importance. Some of the synthesized compounds showed excellent antibacterial activity as compared to individual bacterial activity of OANI and drugs to be used for preparation of composites. |
| doi_str_mv | 10.1007/s00289-018-2502-z |
| format | Article |
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1
HNMR, TGA, GPC, etc. The thermal stability of the compounds was determined by TGA. The molecular weight was determined by GPC. Antibacterial studies of the synthesized compounds were investigated against four Gram-positive (
Staphylococcus aureus
MTCC 96,
Streptococcus pyogenes
MTCC 442,
B
.
subtilis
MTCC 441 and
S. mutans
MTCC 890) and four Gram-negative (
Escherichia coli
MTCC 443,
Pseudomonas aeruginosa
MTCC 1688,
KL. pneumoniae
MTCC 109 and
S. typhi
MTCC 98) bacteria based on their clinical and pharmacological importance. Some of the synthesized compounds showed excellent antibacterial activity as compared to individual bacterial activity of OANI and drugs to be used for preparation of composites.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-018-2502-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alcohol ; Ammonium peroxodisulfate ; Antibiotics ; Antimicrobial agents ; Ascorbic acid ; Bacteria ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Composite materials ; E coli ; Gram-negative bacteria ; Gram-positive bacteria ; Molecular weight ; Organic Chemistry ; Original Paper ; Oxidation ; Oxidizing agents ; Physical Chemistry ; Polymer Sciences ; Polymerization ; Polymers ; Soft and Granular Matter ; Thermal stability ; Vacuum distillation</subject><ispartof>Polymer bulletin (Berlin, Germany), 2019-05, Vol.76 (5), p.2439-2451</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-d4402319a1e9276181298e1b67e5f1ed9c462e3fdce864fef6840711df48b35e3</citedby><cites>FETCH-LOGICAL-c353t-d4402319a1e9276181298e1b67e5f1ed9c462e3fdce864fef6840711df48b35e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-018-2502-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918067671?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,27923,27924,33743,41487,42556,43804,51318,64384,64388,72240</link.rule.ids></links><search><creatorcontrib>Kashyap, Gunjan</creatorcontrib><creatorcontrib>Meghwal, Kiran</creatorcontrib><creatorcontrib>Ameta, Chetna</creatorcontrib><creatorcontrib>Ameta, Rakshit</creatorcontrib><creatorcontrib>Punjabi, Pinki B.</creatorcontrib><title>Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>Oligoaniline (OANI) was prepared using chemical oxidative method using ascorbic acid as a dopant and ammonium persulfate as an oxidant. As-synthesized OANI was subjected for the preparation of various drug composites. All the synthesized compounds were characterized by FTIR,
1
HNMR, TGA, GPC, etc. The thermal stability of the compounds was determined by TGA. The molecular weight was determined by GPC. Antibacterial studies of the synthesized compounds were investigated against four Gram-positive (
Staphylococcus aureus
MTCC 96,
Streptococcus pyogenes
MTCC 442,
B
.
subtilis
MTCC 441 and
S. mutans
MTCC 890) and four Gram-negative (
Escherichia coli
MTCC 443,
Pseudomonas aeruginosa
MTCC 1688,
KL. pneumoniae
MTCC 109 and
S. typhi
MTCC 98) bacteria based on their clinical and pharmacological importance. Some of the synthesized compounds showed excellent antibacterial activity as compared to individual bacterial activity of OANI and drugs to be used for preparation of composites.</description><subject>Alcohol</subject><subject>Ammonium peroxodisulfate</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Ascorbic acid</subject><subject>Bacteria</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Composite materials</subject><subject>E coli</subject><subject>Gram-negative bacteria</subject><subject>Gram-positive bacteria</subject><subject>Molecular weight</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Oxidation</subject><subject>Oxidizing agents</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Soft and Granular Matter</subject><subject>Thermal stability</subject><subject>Vacuum distillation</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kE1LAzEQhoMoWKs_wFvAq9FMNs1mj1L8goIH9RyyyWybst3UZFdof71bKnjyNMzwvs_AQ8g18DvgvLzPnAtdMQ6aiRkXbH9CJiALxYSU1SmZcCg547qozslFzms-7krBhLTvu65fYQ6Zxoba7GKqg6PWBc983KKnsQ3LaLvQhg5vaegz9WlYUhc325hDj5naztPcD353QIywkMZTH2rrekzBtrTGlf0OMV2Ss8a2Ga9-55R8Pj1-zF_Y4u35df6wYK6YFT3zUnJRQGUBK1Eq0CAqjVCrEmcNoK-cVAKLxjvUSjbYKC15CeAbqetihsWU3By52xS_Bsy9WcchdeNLIyrQXJWqhDEFx5RLMeeEjdmmsLFpZ4Cbg1RzlGpGqeYg1ezHjjh28pjtlpj-yP-XfgDUGXu0</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Kashyap, Gunjan</creator><creator>Meghwal, Kiran</creator><creator>Ameta, Chetna</creator><creator>Ameta, Rakshit</creator><creator>Punjabi, Pinki B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20190501</creationdate><title>Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior</title><author>Kashyap, Gunjan ; Meghwal, Kiran ; Ameta, Chetna ; Ameta, Rakshit ; Punjabi, Pinki B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-d4402319a1e9276181298e1b67e5f1ed9c462e3fdce864fef6840711df48b35e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Ammonium peroxodisulfate</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Ascorbic acid</topic><topic>Bacteria</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Composite materials</topic><topic>E coli</topic><topic>Gram-negative bacteria</topic><topic>Gram-positive bacteria</topic><topic>Molecular weight</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Oxidation</topic><topic>Oxidizing agents</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Soft and Granular Matter</topic><topic>Thermal stability</topic><topic>Vacuum distillation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashyap, Gunjan</creatorcontrib><creatorcontrib>Meghwal, Kiran</creatorcontrib><creatorcontrib>Ameta, Chetna</creatorcontrib><creatorcontrib>Ameta, Rakshit</creatorcontrib><creatorcontrib>Punjabi, Pinki B.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashyap, Gunjan</au><au>Meghwal, Kiran</au><au>Ameta, Chetna</au><au>Ameta, Rakshit</au><au>Punjabi, Pinki B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2019-05-01</date><risdate>2019</risdate><volume>76</volume><issue>5</issue><spage>2439</spage><epage>2451</epage><pages>2439-2451</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>Oligoaniline (OANI) was prepared using chemical oxidative method using ascorbic acid as a dopant and ammonium persulfate as an oxidant. As-synthesized OANI was subjected for the preparation of various drug composites. All the synthesized compounds were characterized by FTIR,
1
HNMR, TGA, GPC, etc. The thermal stability of the compounds was determined by TGA. The molecular weight was determined by GPC. Antibacterial studies of the synthesized compounds were investigated against four Gram-positive (
Staphylococcus aureus
MTCC 96,
Streptococcus pyogenes
MTCC 442,
B
.
subtilis
MTCC 441 and
S. mutans
MTCC 890) and four Gram-negative (
Escherichia coli
MTCC 443,
Pseudomonas aeruginosa
MTCC 1688,
KL. pneumoniae
MTCC 109 and
S. typhi
MTCC 98) bacteria based on their clinical and pharmacological importance. Some of the synthesized compounds showed excellent antibacterial activity as compared to individual bacterial activity of OANI and drugs to be used for preparation of composites.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-018-2502-z</doi><tpages>13</tpages></addata></record> |
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| ispartof | Polymer bulletin (Berlin, Germany), 2019-05, Vol.76 (5), p.2439-2451 |
| issn | 0170-0839 1436-2449 |
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| source | ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Alcohol Ammonium peroxodisulfate Antibiotics Antimicrobial agents Ascorbic acid Bacteria Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Composite materials E coli Gram-negative bacteria Gram-positive bacteria Molecular weight Organic Chemistry Original Paper Oxidation Oxidizing agents Physical Chemistry Polymer Sciences Polymerization Polymers Soft and Granular Matter Thermal stability Vacuum distillation |
| title | Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior |
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