Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin
In this study, novel alginate–ferula gum-based hydrogel beads with an antibacterial property which is attributed to the ferula gum were prepared by the ionic interactions method. The hydrogel beads were optimized using the Taguchi experimental design; the effect of the amount of ferula gum, the conc...
Gespeichert in:
Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2021-07, Vol.78 (7), p.3667-3685 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 3685 |
---|---|
container_issue | 7 |
container_start_page | 3667 |
container_title | Polymer bulletin (Berlin, Germany) |
container_volume | 78 |
creator | Seyed Dorraji, M. S. Rasoulifard, M. H. Madadi, S. Doosti, M. Chiti, H. Mousavi, S. N. |
description | In this study, novel alginate–ferula gum-based hydrogel beads with an antibacterial property which is attributed to the ferula gum were prepared by the ionic interactions method. The hydrogel beads were optimized using the Taguchi experimental design; the effect of the amount of ferula gum, the concentration of calcium chloride, and the amount of sodium alginate were investigated on the time required to release 50% of quercetin (Quer) from the hydrogel beads. In summary, ferula gum, calcium chloride, and sodium alginate have impacts on the time required to release 50% of Quer from the hydrogel beads, respectively. Hydrogel beads morphology was determined by XRD, DSC, FE-SEM, and FTIR analyses. The FE-SEM images confirmed that the presence of ferula gum reduces the hydrogel beads pores which reduce drug release rate over a long period. The antibacterial activity of the obtained sample was tested against
Staphylococcus aureus
and
Escherichia coli
, the results exhibited the remarkable antibacterial activity of hydrogel beads containing ferula gum. The hydrogel beads water content was calculated to be 487.34%. Quer release was examined in a buffer medium (pH = 7.4) for 60 h. Quer release from the hydrogel beads was slow and controlled. The release curves were nicely fitted by the Higuchi equation and the release followed by diffusion phenomenon or Fickian’s laws of diffusion. |
doi_str_mv | 10.1007/s00289-020-03293-2 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2918047878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918047878</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-472b57f974eef645a0f76ed031e5f6dc9ed0e1af2bb0e36b57ae2ea9bb3bebaa3</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMoOI6-gKuA62ounV6WMniDARfqOpy0J50MnXRMWqE730F8QZ_E1BHcuTq3__sP_IScc3bJGcuvAmOiKBMmWMKkKGUiDsiMpzJLRJqWh2TGeB5PhSyPyUkIGxbnLOMz8vk0un6NwQYKrqb4Bu0Ave0c7QyNB4rG2Mqiq8ZpA663GqoevYWWrsfadw22VCPUgWoIWNOITlzoajtsKbSNddDj1_uHQT-0QJu4NZ2nNbYwRr3HFiM4ub8O6CvsrTslRwbagGe_dU5ebm-el_fJ6vHuYXm9Siq5yPokzYVe5KbMU0STpQtgJs-wZpLjwmR1VcYeORihNUOZRS2gQCi1lho1gJyTi73vznfxeejVphu8iy-VKHnB0rzIi6gSe1XluxA8GrXzdgt-VJypKX61j1_F-NVP_EpESO6hEMWuQf9n_Q_1DZtgjZM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918047878</pqid></control><display><type>article</type><title>Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin</title><source>SpringerNature Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Seyed Dorraji, M. S. ; Rasoulifard, M. H. ; Madadi, S. ; Doosti, M. ; Chiti, H. ; Mousavi, S. N.</creator><creatorcontrib>Seyed Dorraji, M. S. ; Rasoulifard, M. H. ; Madadi, S. ; Doosti, M. ; Chiti, H. ; Mousavi, S. N.</creatorcontrib><description>In this study, novel alginate–ferula gum-based hydrogel beads with an antibacterial property which is attributed to the ferula gum were prepared by the ionic interactions method. The hydrogel beads were optimized using the Taguchi experimental design; the effect of the amount of ferula gum, the concentration of calcium chloride, and the amount of sodium alginate were investigated on the time required to release 50% of quercetin (Quer) from the hydrogel beads. In summary, ferula gum, calcium chloride, and sodium alginate have impacts on the time required to release 50% of Quer from the hydrogel beads, respectively. Hydrogel beads morphology was determined by XRD, DSC, FE-SEM, and FTIR analyses. The FE-SEM images confirmed that the presence of ferula gum reduces the hydrogel beads pores which reduce drug release rate over a long period. The antibacterial activity of the obtained sample was tested against
Staphylococcus aureus
and
Escherichia coli
, the results exhibited the remarkable antibacterial activity of hydrogel beads containing ferula gum. The hydrogel beads water content was calculated to be 487.34%. Quer release was examined in a buffer medium (pH = 7.4) for 60 h. Quer release from the hydrogel beads was slow and controlled. The release curves were nicely fitted by the Higuchi equation and the release followed by diffusion phenomenon or Fickian’s laws of diffusion.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-020-03293-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bioavailability ; Biopolymers ; Calcium chloride ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Design of experiments ; Design optimization ; Drug delivery systems ; E coli ; Ethanol ; Fourier transforms ; Hydrogels ; Ionic interactions ; Moisture content ; Morphology ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Polymer Sciences ; Polymers ; Scanning electron microscopy ; Sodium ; Sodium alginate ; Soft and Granular Matter</subject><ispartof>Polymer bulletin (Berlin, Germany), 2021-07, Vol.78 (7), p.3667-3685</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-472b57f974eef645a0f76ed031e5f6dc9ed0e1af2bb0e36b57ae2ea9bb3bebaa3</citedby><cites>FETCH-LOGICAL-c356t-472b57f974eef645a0f76ed031e5f6dc9ed0e1af2bb0e36b57ae2ea9bb3bebaa3</cites><orcidid>0000-0002-8712-1838</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-020-03293-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918047878?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,27924,27925,33744,41488,42557,43805,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Seyed Dorraji, M. S.</creatorcontrib><creatorcontrib>Rasoulifard, M. H.</creatorcontrib><creatorcontrib>Madadi, S.</creatorcontrib><creatorcontrib>Doosti, M.</creatorcontrib><creatorcontrib>Chiti, H.</creatorcontrib><creatorcontrib>Mousavi, S. N.</creatorcontrib><title>Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>In this study, novel alginate–ferula gum-based hydrogel beads with an antibacterial property which is attributed to the ferula gum were prepared by the ionic interactions method. The hydrogel beads were optimized using the Taguchi experimental design; the effect of the amount of ferula gum, the concentration of calcium chloride, and the amount of sodium alginate were investigated on the time required to release 50% of quercetin (Quer) from the hydrogel beads. In summary, ferula gum, calcium chloride, and sodium alginate have impacts on the time required to release 50% of Quer from the hydrogel beads, respectively. Hydrogel beads morphology was determined by XRD, DSC, FE-SEM, and FTIR analyses. The FE-SEM images confirmed that the presence of ferula gum reduces the hydrogel beads pores which reduce drug release rate over a long period. The antibacterial activity of the obtained sample was tested against
Staphylococcus aureus
and
Escherichia coli
, the results exhibited the remarkable antibacterial activity of hydrogel beads containing ferula gum. The hydrogel beads water content was calculated to be 487.34%. Quer release was examined in a buffer medium (pH = 7.4) for 60 h. Quer release from the hydrogel beads was slow and controlled. The release curves were nicely fitted by the Higuchi equation and the release followed by diffusion phenomenon or Fickian’s laws of diffusion.</description><subject>Bioavailability</subject><subject>Biopolymers</subject><subject>Calcium chloride</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Design of experiments</subject><subject>Design optimization</subject><subject>Drug delivery systems</subject><subject>E coli</subject><subject>Ethanol</subject><subject>Fourier transforms</subject><subject>Hydrogels</subject><subject>Ionic interactions</subject><subject>Moisture content</subject><subject>Morphology</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Scanning electron microscopy</subject><subject>Sodium</subject><subject>Sodium alginate</subject><subject>Soft and Granular Matter</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kMtKxDAUhoMoOI6-gKuA62ounV6WMniDARfqOpy0J50MnXRMWqE730F8QZ_E1BHcuTq3__sP_IScc3bJGcuvAmOiKBMmWMKkKGUiDsiMpzJLRJqWh2TGeB5PhSyPyUkIGxbnLOMz8vk0un6NwQYKrqb4Bu0Ave0c7QyNB4rG2Mqiq8ZpA663GqoevYWWrsfadw22VCPUgWoIWNOITlzoajtsKbSNddDj1_uHQT-0QJu4NZ2nNbYwRr3HFiM4ub8O6CvsrTslRwbagGe_dU5ebm-el_fJ6vHuYXm9Siq5yPokzYVe5KbMU0STpQtgJs-wZpLjwmR1VcYeORihNUOZRS2gQCi1lho1gJyTi73vznfxeejVphu8iy-VKHnB0rzIi6gSe1XluxA8GrXzdgt-VJypKX61j1_F-NVP_EpESO6hEMWuQf9n_Q_1DZtgjZM</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Seyed Dorraji, M. S.</creator><creator>Rasoulifard, M. H.</creator><creator>Madadi, S.</creator><creator>Doosti, M.</creator><creator>Chiti, H.</creator><creator>Mousavi, S. N.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-8712-1838</orcidid></search><sort><creationdate>20210701</creationdate><title>Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin</title><author>Seyed Dorraji, M. S. ; Rasoulifard, M. H. ; Madadi, S. ; Doosti, M. ; Chiti, H. ; Mousavi, S. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-472b57f974eef645a0f76ed031e5f6dc9ed0e1af2bb0e36b57ae2ea9bb3bebaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bioavailability</topic><topic>Biopolymers</topic><topic>Calcium chloride</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Design of experiments</topic><topic>Design optimization</topic><topic>Drug delivery systems</topic><topic>E coli</topic><topic>Ethanol</topic><topic>Fourier transforms</topic><topic>Hydrogels</topic><topic>Ionic interactions</topic><topic>Moisture content</topic><topic>Morphology</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Scanning electron microscopy</topic><topic>Sodium</topic><topic>Sodium alginate</topic><topic>Soft and Granular Matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seyed Dorraji, M. S.</creatorcontrib><creatorcontrib>Rasoulifard, M. H.</creatorcontrib><creatorcontrib>Madadi, S.</creatorcontrib><creatorcontrib>Doosti, M.</creatorcontrib><creatorcontrib>Chiti, H.</creatorcontrib><creatorcontrib>Mousavi, S. N.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seyed Dorraji, M. S.</au><au>Rasoulifard, M. H.</au><au>Madadi, S.</au><au>Doosti, M.</au><au>Chiti, H.</au><au>Mousavi, S. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>78</volume><issue>7</issue><spage>3667</spage><epage>3685</epage><pages>3667-3685</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>In this study, novel alginate–ferula gum-based hydrogel beads with an antibacterial property which is attributed to the ferula gum were prepared by the ionic interactions method. The hydrogel beads were optimized using the Taguchi experimental design; the effect of the amount of ferula gum, the concentration of calcium chloride, and the amount of sodium alginate were investigated on the time required to release 50% of quercetin (Quer) from the hydrogel beads. In summary, ferula gum, calcium chloride, and sodium alginate have impacts on the time required to release 50% of Quer from the hydrogel beads, respectively. Hydrogel beads morphology was determined by XRD, DSC, FE-SEM, and FTIR analyses. The FE-SEM images confirmed that the presence of ferula gum reduces the hydrogel beads pores which reduce drug release rate over a long period. The antibacterial activity of the obtained sample was tested against
Staphylococcus aureus
and
Escherichia coli
, the results exhibited the remarkable antibacterial activity of hydrogel beads containing ferula gum. The hydrogel beads water content was calculated to be 487.34%. Quer release was examined in a buffer medium (pH = 7.4) for 60 h. Quer release from the hydrogel beads was slow and controlled. The release curves were nicely fitted by the Higuchi equation and the release followed by diffusion phenomenon or Fickian’s laws of diffusion.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-020-03293-2</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-8712-1838</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0170-0839 |
ispartof | Polymer bulletin (Berlin, Germany), 2021-07, Vol.78 (7), p.3667-3685 |
issn | 0170-0839 1436-2449 |
language | eng |
recordid | cdi_proquest_journals_2918047878 |
source | SpringerNature Journals; ProQuest Central UK/Ireland; ProQuest Central |
subjects | Bioavailability Biopolymers Calcium chloride Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Design of experiments Design optimization Drug delivery systems E coli Ethanol Fourier transforms Hydrogels Ionic interactions Moisture content Morphology Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Polymers Scanning electron microscopy Sodium Sodium alginate Soft and Granular Matter |
title | Synthesis and evaluation of the efficiency of antibacterial hydrogel beads based on the sodium alginate–ferula gum for delayed release of quercetin |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A40%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20evaluation%20of%20the%20efficiency%20of%20antibacterial%20hydrogel%20beads%20based%20on%20the%20sodium%20alginate%E2%80%93ferula%20gum%20for%20delayed%20release%20of%20quercetin&rft.jtitle=Polymer%20bulletin%20(Berlin,%20Germany)&rft.au=Seyed%20Dorraji,%20M.%20S.&rft.date=2021-07-01&rft.volume=78&rft.issue=7&rft.spage=3667&rft.epage=3685&rft.pages=3667-3685&rft.issn=0170-0839&rft.eissn=1436-2449&rft_id=info:doi/10.1007/s00289-020-03293-2&rft_dat=%3Cproquest_cross%3E2918047878%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2918047878&rft_id=info:pmid/&rfr_iscdi=true |