Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin
Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of re...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2020-11, Vol.77 (11), p.5615-5629 |
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| creator | Nadem, Sara Ziyadi, Hakimeh Hekmati, Malak Baghali, Mitra |
| description | Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. The prepared mats of nanofibers were characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared and contact angle analysis. The in vitro drug release from nanofibers into the phosphate-buffered saline solution was measured by high-performance liquid chromatography at a wavelength of 210 nm. The in vitro drug release showed that cross-linked nanofibers had a lower drug release rate in a longer time. |
| doi_str_mv | 10.1007/s00289-019-03027-z |
| format | Article |
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First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. The prepared mats of nanofibers were characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared and contact angle analysis. The in vitro drug release from nanofibers into the phosphate-buffered saline solution was measured by high-performance liquid chromatography at a wavelength of 210 nm. The in vitro drug release showed that cross-linked nanofibers had a lower drug release rate in a longer time.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-019-03027-z</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aluminum ; Antibiotics ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Complex Fluids and Microfluidics ; Contact angle ; Crosslinking ; Drug carriers ; Drug delivery systems ; Electrospinning ; Fourier transforms ; Gram-positive bacteria ; High performance liquid chromatography ; Infrared analysis ; Mechanical properties ; Microscopy ; Nanofibers ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Polymer Sciences ; Polymers ; Polyvinyl alcohol ; Potassium ; Saline solutions ; Skin ; Soft and Granular Matter ; Temperature</subject><ispartof>Polymer bulletin (Berlin, Germany), 2020-11, Vol.77 (11), p.5615-5629</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-dbb422238fad1270e09c88b0b4fbed5f0d7a3fbdd73635c5f0900022af8c773b3</citedby><cites>FETCH-LOGICAL-c356t-dbb422238fad1270e09c88b0b4fbed5f0d7a3fbdd73635c5f0900022af8c773b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-019-03027-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918027025?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,27924,27925,33744,41488,42557,43805,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Nadem, Sara</creatorcontrib><creatorcontrib>Ziyadi, Hakimeh</creatorcontrib><creatorcontrib>Hekmati, Malak</creatorcontrib><creatorcontrib>Baghali, Mitra</creatorcontrib><title>Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. The prepared mats of nanofibers were characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared and contact angle analysis. The in vitro drug release from nanofibers into the phosphate-buffered saline solution was measured by high-performance liquid chromatography at a wavelength of 210 nm. The in vitro drug release showed that cross-linked nanofibers had a lower drug release rate in a longer time.</description><subject>Aluminum</subject><subject>Antibiotics</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Complex Fluids and Microfluidics</subject><subject>Contact angle</subject><subject>Crosslinking</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Electrospinning</subject><subject>Fourier transforms</subject><subject>Gram-positive bacteria</subject><subject>High performance liquid chromatography</subject><subject>Infrared analysis</subject><subject>Mechanical properties</subject><subject>Microscopy</subject><subject>Nanofibers</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Polyvinyl alcohol</subject><subject>Potassium</subject><subject>Saline solutions</subject><subject>Skin</subject><subject>Soft and Granular Matter</subject><subject>Temperature</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kE1LAzEQhoMoWKt_wFPAix6ik2R3s3uU4icFL3oO-axbt5uatML215u6gjcPwzDD-87wPgidU7imAOImAbC6IUBzcWCC7A7QhBa8IqwomkM0ASqAQM2bY3SS0hLyXFV0gp5nMaREurb_cBavQzdcfrX90GHVmfAeuivcqz74VruYsErYxu0CGxVj6yIOHpvstGo1mLY_RUdedcmd_fYperu_e509kvnLw9Psdk4ML6sNsVoXjDFee2UpE-CgMXWtQRdeO1t6sEJxr60VvOKlyYsGcjqmfG2E4JpP0cV4dx3D59aljVyGbezzS8kaWuf0wMqsYqPK7ANG5-U6tisVB0lB7pnJkZnMzOQPM7nLJj6aUhb3Cxf_Tv_j-ga-dW_7</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Nadem, Sara</creator><creator>Ziyadi, Hakimeh</creator><creator>Hekmati, Malak</creator><creator>Baghali, Mitra</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20201101</creationdate><title>Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin</title><author>Nadem, Sara ; Ziyadi, Hakimeh ; Hekmati, Malak ; Baghali, Mitra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-dbb422238fad1270e09c88b0b4fbed5f0d7a3fbdd73635c5f0900022af8c773b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminum</topic><topic>Antibiotics</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Complex Fluids and Microfluidics</topic><topic>Contact angle</topic><topic>Crosslinking</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Electrospinning</topic><topic>Fourier transforms</topic><topic>Gram-positive bacteria</topic><topic>High performance liquid chromatography</topic><topic>Infrared analysis</topic><topic>Mechanical properties</topic><topic>Microscopy</topic><topic>Nanofibers</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Polyvinyl alcohol</topic><topic>Potassium</topic><topic>Saline solutions</topic><topic>Skin</topic><topic>Soft and Granular Matter</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadem, Sara</creatorcontrib><creatorcontrib>Ziyadi, Hakimeh</creatorcontrib><creatorcontrib>Hekmati, Malak</creatorcontrib><creatorcontrib>Baghali, Mitra</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadem, Sara</au><au>Ziyadi, Hakimeh</au><au>Hekmati, Malak</au><au>Baghali, Mitra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2020-11-01</date><risdate>2020</risdate><volume>77</volume><issue>11</issue><spage>5615</spage><epage>5629</epage><pages>5615-5629</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. 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| subjects | Aluminum Antibiotics Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography Complex Fluids and Microfluidics Contact angle Crosslinking Drug carriers Drug delivery systems Electrospinning Fourier transforms Gram-positive bacteria High performance liquid chromatography Infrared analysis Mechanical properties Microscopy Nanofibers Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Polymers Polyvinyl alcohol Potassium Saline solutions Skin Soft and Granular Matter Temperature |
| title | Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin |
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