Interpenetrating network of gelatin/acrylamide: a binary approach for sustained release and anti-ulcerent effect of RNT
In the present study, main complication associated with duodenal ulcer is bleeding that was due to frequent use of NSAIDs, which was treated by ranitidine HCL (RNT). For the targeted release of RNT, pH-sensitive gelatin/acrylamide networks were synthesized by free radical polymerization, and the eff...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2022-07, Vol.79 (7), p.5569-5585 |
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| creator | Ramzan, Nasreen Ranjha, Nazar Muhammad Hanif, Muhammad Bashir, Zakia Mahmood, Khalid Rehman, Sadia Latif, Hafsa Ameer, Nabeela Aziz, Mubashar Abbas, Ghulam |
| description | In the present study, main complication associated with duodenal ulcer is bleeding that was due to frequent use of NSAIDs, which was treated by ranitidine HCL (RNT). For the targeted release of RNT, pH-sensitive gelatin/acrylamide networks were synthesized by free radical polymerization, and the effect of different concentrations of initiator, monomer, polymer, and cross-linker on swelling was observed. Average molecular weight (Mc), volume fraction of the polymer
V
2
, solvent interaction parameter, and cross-linked density were calculated. FTIR and SEM studies were performed for the interaction and morphological studies of networks. Dissolution efficiency (DE) and percentage release of RNT were analyzed in acidic media as well as in alkaline phosphate buffer pH 7.5. 80% swelling in phosphate buffer of pH 7.5 in 12 h showed inverse behavior with the concentration of cross-linker and direct relation with the gelatin. Akaike information criteria (AIC) were used for the selection of one best model. Formulation AAm1Ge1 at pH 7.5 has the best fitting curve with maximum regression coefficient 0.94 and minimum 66 AIC values. 80% RNT release with non-Fickian behavior and was observed in all prepared networks. Proposed networks formulations can be used for the treatment of NSAIDs induced duodenal ulcer. |
| doi_str_mv | 10.1007/s00289-021-03831-6 |
| format | Article |
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V
2
, solvent interaction parameter, and cross-linked density were calculated. FTIR and SEM studies were performed for the interaction and morphological studies of networks. Dissolution efficiency (DE) and percentage release of RNT were analyzed in acidic media as well as in alkaline phosphate buffer pH 7.5. 80% swelling in phosphate buffer of pH 7.5 in 12 h showed inverse behavior with the concentration of cross-linker and direct relation with the gelatin. Akaike information criteria (AIC) were used for the selection of one best model. Formulation AAm1Ge1 at pH 7.5 has the best fitting curve with maximum regression coefficient 0.94 and minimum 66 AIC values. 80% RNT release with non-Fickian behavior and was observed in all prepared networks. Proposed networks formulations can be used for the treatment of NSAIDs induced duodenal ulcer.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-021-03831-6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acrylamide ; Biocompatibility ; Buffers ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Crosslinking ; Curve fitting ; Drug delivery systems ; Equilibrium ; Free radical polymerization ; Free radicals ; Gelatin ; Interaction parameters ; Interpenetrating networks ; Mechanical properties ; Molecular weight ; Networks ; Nonsteroidal anti-inflammatory drugs ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Polymer Sciences ; Polymerization ; Polymers ; Regression coefficients ; Soft and Granular Matter ; Solvents ; Sustained release ; Swelling ; Ulcers</subject><ispartof>Polymer bulletin (Berlin, Germany), 2022-07, Vol.79 (7), p.5569-5585</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-7df33eb5aa6c91755eb335c72e560398521f741e77179b41cf5f5e027c0dc3093</citedby><cites>FETCH-LOGICAL-c319t-7df33eb5aa6c91755eb335c72e560398521f741e77179b41cf5f5e027c0dc3093</cites><orcidid>0000-0002-2303-3804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-021-03831-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918003702?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Ramzan, Nasreen</creatorcontrib><creatorcontrib>Ranjha, Nazar Muhammad</creatorcontrib><creatorcontrib>Hanif, Muhammad</creatorcontrib><creatorcontrib>Bashir, Zakia</creatorcontrib><creatorcontrib>Mahmood, Khalid</creatorcontrib><creatorcontrib>Rehman, Sadia</creatorcontrib><creatorcontrib>Latif, Hafsa</creatorcontrib><creatorcontrib>Ameer, Nabeela</creatorcontrib><creatorcontrib>Aziz, Mubashar</creatorcontrib><creatorcontrib>Abbas, Ghulam</creatorcontrib><title>Interpenetrating network of gelatin/acrylamide: a binary approach for sustained release and anti-ulcerent effect of RNT</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>In the present study, main complication associated with duodenal ulcer is bleeding that was due to frequent use of NSAIDs, which was treated by ranitidine HCL (RNT). For the targeted release of RNT, pH-sensitive gelatin/acrylamide networks were synthesized by free radical polymerization, and the effect of different concentrations of initiator, monomer, polymer, and cross-linker on swelling was observed. Average molecular weight (Mc), volume fraction of the polymer
V
2
, solvent interaction parameter, and cross-linked density were calculated. FTIR and SEM studies were performed for the interaction and morphological studies of networks. Dissolution efficiency (DE) and percentage release of RNT were analyzed in acidic media as well as in alkaline phosphate buffer pH 7.5. 80% swelling in phosphate buffer of pH 7.5 in 12 h showed inverse behavior with the concentration of cross-linker and direct relation with the gelatin. Akaike information criteria (AIC) were used for the selection of one best model. Formulation AAm1Ge1 at pH 7.5 has the best fitting curve with maximum regression coefficient 0.94 and minimum 66 AIC values. 80% RNT release with non-Fickian behavior and was observed in all prepared networks. Proposed networks formulations can be used for the treatment of NSAIDs induced duodenal ulcer.</description><subject>Acrylamide</subject><subject>Biocompatibility</subject><subject>Buffers</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Crosslinking</subject><subject>Curve fitting</subject><subject>Drug delivery systems</subject><subject>Equilibrium</subject><subject>Free radical polymerization</subject><subject>Free radicals</subject><subject>Gelatin</subject><subject>Interaction parameters</subject><subject>Interpenetrating networks</subject><subject>Mechanical properties</subject><subject>Molecular weight</subject><subject>Networks</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Regression coefficients</subject><subject>Soft and Granular Matter</subject><subject>Solvents</subject><subject>Sustained release</subject><subject>Swelling</subject><subject>Ulcers</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9UE1LAzEQDaJg_fgDngKeo5Nkd7PxJsUvKAqi55BmJ3V1m61JSvHfm1rBm4dhPnjvzcwj5IzDBQdQlwlAtJqB4AxkKzlr9siEV7Jhoqr0PpkAV8CglfqQHKX0DqVvGj4hm4eQMa4wYI4292FBS7UZ4wcdPV3gsJ1dWhe_BrvsO7yils77YOMXtatVHK17o36MNK1Ttn3AjkYc0CakNnQlcs_Wg8OIIVP0Hl3e6j4_vpyQA2-HhKe_-Zi83t68TO_Z7OnuYXo9Y05ynZnqvJQ4r61tnOaqrnEuZe2UwLoBqdtacK8qjkpxpecVd772NYJQDjonQctjcr7TLcd-rjFl8z6uYygrjdC8BZAKREGJHcrFMaWI3qxivyxfGg5ma7DZGWyKwebHYNMUktyRUgGHBcY_6X9Y38W0fvg</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Ramzan, Nasreen</creator><creator>Ranjha, Nazar Muhammad</creator><creator>Hanif, Muhammad</creator><creator>Bashir, Zakia</creator><creator>Mahmood, Khalid</creator><creator>Rehman, Sadia</creator><creator>Latif, Hafsa</creator><creator>Ameer, Nabeela</creator><creator>Aziz, Mubashar</creator><creator>Abbas, Ghulam</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0002-2303-3804</orcidid></search><sort><creationdate>20220701</creationdate><title>Interpenetrating network of gelatin/acrylamide: a binary approach for sustained release and anti-ulcerent effect of RNT</title><author>Ramzan, Nasreen ; Ranjha, Nazar Muhammad ; Hanif, Muhammad ; Bashir, Zakia ; Mahmood, Khalid ; Rehman, Sadia ; Latif, Hafsa ; Ameer, Nabeela ; Aziz, Mubashar ; Abbas, Ghulam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-7df33eb5aa6c91755eb335c72e560398521f741e77179b41cf5f5e027c0dc3093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acrylamide</topic><topic>Biocompatibility</topic><topic>Buffers</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Crosslinking</topic><topic>Curve fitting</topic><topic>Drug delivery systems</topic><topic>Equilibrium</topic><topic>Free radical polymerization</topic><topic>Free radicals</topic><topic>Gelatin</topic><topic>Interaction parameters</topic><topic>Interpenetrating networks</topic><topic>Mechanical properties</topic><topic>Molecular weight</topic><topic>Networks</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Regression coefficients</topic><topic>Soft and Granular Matter</topic><topic>Solvents</topic><topic>Sustained release</topic><topic>Swelling</topic><topic>Ulcers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramzan, Nasreen</creatorcontrib><creatorcontrib>Ranjha, Nazar Muhammad</creatorcontrib><creatorcontrib>Hanif, Muhammad</creatorcontrib><creatorcontrib>Bashir, Zakia</creatorcontrib><creatorcontrib>Mahmood, Khalid</creatorcontrib><creatorcontrib>Rehman, Sadia</creatorcontrib><creatorcontrib>Latif, Hafsa</creatorcontrib><creatorcontrib>Ameer, Nabeela</creatorcontrib><creatorcontrib>Aziz, Mubashar</creatorcontrib><creatorcontrib>Abbas, Ghulam</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramzan, Nasreen</au><au>Ranjha, Nazar Muhammad</au><au>Hanif, Muhammad</au><au>Bashir, Zakia</au><au>Mahmood, Khalid</au><au>Rehman, Sadia</au><au>Latif, Hafsa</au><au>Ameer, Nabeela</au><au>Aziz, Mubashar</au><au>Abbas, Ghulam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interpenetrating network of gelatin/acrylamide: a binary approach for sustained release and anti-ulcerent effect of RNT</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. 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V
2
, solvent interaction parameter, and cross-linked density were calculated. FTIR and SEM studies were performed for the interaction and morphological studies of networks. Dissolution efficiency (DE) and percentage release of RNT were analyzed in acidic media as well as in alkaline phosphate buffer pH 7.5. 80% swelling in phosphate buffer of pH 7.5 in 12 h showed inverse behavior with the concentration of cross-linker and direct relation with the gelatin. Akaike information criteria (AIC) were used for the selection of one best model. Formulation AAm1Ge1 at pH 7.5 has the best fitting curve with maximum regression coefficient 0.94 and minimum 66 AIC values. 80% RNT release with non-Fickian behavior and was observed in all prepared networks. Proposed networks formulations can be used for the treatment of NSAIDs induced duodenal ulcer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-021-03831-6</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-2303-3804</orcidid></addata></record> |
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| ispartof | Polymer bulletin (Berlin, Germany), 2022-07, Vol.79 (7), p.5569-5585 |
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| subjects | Acrylamide Biocompatibility Buffers Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Crosslinking Curve fitting Drug delivery systems Equilibrium Free radical polymerization Free radicals Gelatin Interaction parameters Interpenetrating networks Mechanical properties Molecular weight Networks Nonsteroidal anti-inflammatory drugs Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Polymerization Polymers Regression coefficients Soft and Granular Matter Solvents Sustained release Swelling Ulcers |
| title | Interpenetrating network of gelatin/acrylamide: a binary approach for sustained release and anti-ulcerent effect of RNT |
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