The effect of aliphatic esters on the formation and degradation behavior of PLGA-based in situ forming system
The purpose of this study was to investigate the effect of three aliphatic esters, ethyl heptanoate, methyl heptanoate, and ethyl nonanoate on the in vitro degradation behavior of in situ forming systems. In situ forming implants based on 33% (w/w) poly (lactide-co-glycolide) (PLGA)/57% (w/w) N -met...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2011-05, Vol.66 (8), p.1063-1073 |
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| creator | Mashak, A. Mobedi, H. Ziaee, F. Nekoomanesh, M. |
| description | The purpose of this study was to investigate the effect of three aliphatic esters, ethyl heptanoate, methyl heptanoate, and ethyl nonanoate on the in vitro degradation behavior of in situ forming systems. In situ forming implants based on 33% (w/w) poly (lactide-co-glycolide) (PLGA)/57% (w/w)
N
-methyl-2-pyrrolidone (NMP)/10% (w/w) esters were prepared after injection of the final formulation in phosphate buffer solution (pH 7.4, 0.2 M) at 37 °C. The influence of additives on the implants formation, morphology, and also on their in vitro degradation behaviors over a period of 45 days was investigated. The degraded matrices were evaluated to determine morphological analysis by SEM and
1
H-NMR study. The solution of degradation medium was studied to indicate NMP removal and altering acidity. The results showed that the additives generated a high porous structure and caused the fast phase inversion. However, the
1
H-NMR spectra indicated that ester additives remained in the matrices during degradation periods. The results of the acidity study showed that the degradation rates in the matrices containing esters were higher than the control matrix. In addition, it is shown that esters with lower molecular weight have affected the polymer degradation more efficiently than higher molecular weight esters. |
| doi_str_mv | 10.1007/s00289-010-0386-7 |
| format | Article |
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N
-methyl-2-pyrrolidone (NMP)/10% (w/w) esters were prepared after injection of the final formulation in phosphate buffer solution (pH 7.4, 0.2 M) at 37 °C. The influence of additives on the implants formation, morphology, and also on their in vitro degradation behaviors over a period of 45 days was investigated. The degraded matrices were evaluated to determine morphological analysis by SEM and
1
H-NMR study. The solution of degradation medium was studied to indicate NMP removal and altering acidity. The results showed that the additives generated a high porous structure and caused the fast phase inversion. However, the
1
H-NMR spectra indicated that ester additives remained in the matrices during degradation periods. The results of the acidity study showed that the degradation rates in the matrices containing esters were higher than the control matrix. In addition, it is shown that esters with lower molecular weight have affected the polymer degradation more efficiently than higher molecular weight esters.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-010-0386-7</identifier><identifier>CODEN: POBUDR</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Additives ; Aliphatic compounds ; Applied sciences ; Biological and medical sciences ; Buffer solutions ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Complex Fluids and Microfluidics ; Degradation ; Drug delivery systems ; Esters ; Exact sciences and technology ; General pharmacology ; Implants ; Medical sciences ; Molecular weight ; Morphology ; NMR ; Nuclear magnetic resonance ; Organic Chemistry ; Organic polymers ; Original Paper ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physical Chemistry ; Physicochemistry of polymers ; Polymer Sciences ; Polymers ; Properties and characterization ; Scanning electron microscopy ; Soft and Granular Matter ; Solidification ; Solvents ; Special properties (catalyst, reagent or carrier) ; Transplants & implants</subject><ispartof>Polymer bulletin (Berlin, Germany), 2011-05, Vol.66 (8), p.1063-1073</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-c37d6f979c97666da11b0e59afa6112117bcdaeaa59f98ea4a930b08ace8729b3</citedby><cites>FETCH-LOGICAL-c346t-c37d6f979c97666da11b0e59afa6112117bcdaeaa59f98ea4a930b08ace8729b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-010-0386-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917986633?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21386,27922,27923,33742,41486,42555,43803,51317,64383,64387,72239</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24123176$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Mashak, A.</creatorcontrib><creatorcontrib>Mobedi, H.</creatorcontrib><creatorcontrib>Ziaee, F.</creatorcontrib><creatorcontrib>Nekoomanesh, M.</creatorcontrib><title>The effect of aliphatic esters on the formation and degradation behavior of PLGA-based in situ forming system</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>The purpose of this study was to investigate the effect of three aliphatic esters, ethyl heptanoate, methyl heptanoate, and ethyl nonanoate on the in vitro degradation behavior of in situ forming systems. In situ forming implants based on 33% (w/w) poly (lactide-co-glycolide) (PLGA)/57% (w/w)
N
-methyl-2-pyrrolidone (NMP)/10% (w/w) esters were prepared after injection of the final formulation in phosphate buffer solution (pH 7.4, 0.2 M) at 37 °C. The influence of additives on the implants formation, morphology, and also on their in vitro degradation behaviors over a period of 45 days was investigated. The degraded matrices were evaluated to determine morphological analysis by SEM and
1
H-NMR study. The solution of degradation medium was studied to indicate NMP removal and altering acidity. The results showed that the additives generated a high porous structure and caused the fast phase inversion. However, the
1
H-NMR spectra indicated that ester additives remained in the matrices during degradation periods. The results of the acidity study showed that the degradation rates in the matrices containing esters were higher than the control matrix. In addition, it is shown that esters with lower molecular weight have affected the polymer degradation more efficiently than higher molecular weight esters.</description><subject>Additives</subject><subject>Aliphatic compounds</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Buffer solutions</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Complex Fluids and Microfluidics</subject><subject>Degradation</subject><subject>Drug delivery systems</subject><subject>Esters</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Implants</subject><subject>Medical sciences</subject><subject>Molecular weight</subject><subject>Morphology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic Chemistry</subject><subject>Organic polymers</subject><subject>Original Paper</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Chemistry</subject><subject>Physicochemistry of polymers</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Properties and characterization</subject><subject>Scanning electron microscopy</subject><subject>Soft and Granular Matter</subject><subject>Solidification</subject><subject>Solvents</subject><subject>Special properties (catalyst, reagent or carrier)</subject><subject>Transplants & implants</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UMFKAzEQDaJgrX6At4B4XM1stsnmWIpWoaCHeg6z2aRN6e7WZCv0703doicvM7zMe28mj5BbYA_AmHyMjOWlyhiwjPFSZPKMjKDgIsuLQp2TEQOZJiVXl-Qqxg1LWAgYkWa5ttQ6Z01PO0dx63dr7L2hNvY2RNq1tE8M14UmPSeEbU1ruwpYD7iya_zyXTiq3xfzaVZhtDX1LY2-3_8Ifbui8ZD8mmty4XAb7c2pj8nH89Ny9pIt3uavs-kiM7wQfaqyFk5JZVS6UtQIUDE7UehQAOQAsjI1WsSJcqq0WKDirGIlGlvKXFV8TO4G313oPvfpK3rT7UObVupcgVSlEJwnFgwsE7oYg3V6F3yD4aCB6WOqekhVp1T1MVUtk-b-5IzR4NYFbI2Pv8K8gJynaBMvH3gxjdqVDX8X_G_-DaYMh70</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Mashak, A.</creator><creator>Mobedi, H.</creator><creator>Ziaee, F.</creator><creator>Nekoomanesh, M.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20110501</creationdate><title>The effect of aliphatic esters on the formation and degradation behavior of PLGA-based in situ forming system</title><author>Mashak, A. ; Mobedi, H. ; Ziaee, F. ; Nekoomanesh, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-c37d6f979c97666da11b0e59afa6112117bcdaeaa59f98ea4a930b08ace8729b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Additives</topic><topic>Aliphatic compounds</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Buffer solutions</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>Complex Fluids and Microfluidics</topic><topic>Degradation</topic><topic>Drug delivery systems</topic><topic>Esters</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Implants</topic><topic>Medical sciences</topic><topic>Molecular weight</topic><topic>Morphology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic Chemistry</topic><topic>Organic polymers</topic><topic>Original Paper</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Chemistry</topic><topic>Physicochemistry of polymers</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Properties and characterization</topic><topic>Scanning electron microscopy</topic><topic>Soft and Granular Matter</topic><topic>Solidification</topic><topic>Solvents</topic><topic>Special properties (catalyst, reagent or carrier)</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mashak, A.</creatorcontrib><creatorcontrib>Mobedi, H.</creatorcontrib><creatorcontrib>Ziaee, F.</creatorcontrib><creatorcontrib>Nekoomanesh, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mashak, A.</au><au>Mobedi, H.</au><au>Ziaee, F.</au><au>Nekoomanesh, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of aliphatic esters on the formation and degradation behavior of PLGA-based in situ forming system</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2011-05-01</date><risdate>2011</risdate><volume>66</volume><issue>8</issue><spage>1063</spage><epage>1073</epage><pages>1063-1073</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><coden>POBUDR</coden><abstract>The purpose of this study was to investigate the effect of three aliphatic esters, ethyl heptanoate, methyl heptanoate, and ethyl nonanoate on the in vitro degradation behavior of in situ forming systems. In situ forming implants based on 33% (w/w) poly (lactide-co-glycolide) (PLGA)/57% (w/w)
N
-methyl-2-pyrrolidone (NMP)/10% (w/w) esters were prepared after injection of the final formulation in phosphate buffer solution (pH 7.4, 0.2 M) at 37 °C. The influence of additives on the implants formation, morphology, and also on their in vitro degradation behaviors over a period of 45 days was investigated. The degraded matrices were evaluated to determine morphological analysis by SEM and
1
H-NMR study. The solution of degradation medium was studied to indicate NMP removal and altering acidity. The results showed that the additives generated a high porous structure and caused the fast phase inversion. However, the
1
H-NMR spectra indicated that ester additives remained in the matrices during degradation periods. The results of the acidity study showed that the degradation rates in the matrices containing esters were higher than the control matrix. In addition, it is shown that esters with lower molecular weight have affected the polymer degradation more efficiently than higher molecular weight esters.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><doi>10.1007/s00289-010-0386-7</doi><tpages>11</tpages></addata></record> |
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| ispartof | Polymer bulletin (Berlin, Germany), 2011-05, Vol.66 (8), p.1063-1073 |
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| source | ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Additives Aliphatic compounds Applied sciences Biological and medical sciences Buffer solutions Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chromatography Complex Fluids and Microfluidics Degradation Drug delivery systems Esters Exact sciences and technology General pharmacology Implants Medical sciences Molecular weight Morphology NMR Nuclear magnetic resonance Organic Chemistry Organic polymers Original Paper Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Physicochemistry of polymers Polymer Sciences Polymers Properties and characterization Scanning electron microscopy Soft and Granular Matter Solidification Solvents Special properties (catalyst, reagent or carrier) Transplants & implants |
| title | The effect of aliphatic esters on the formation and degradation behavior of PLGA-based in situ forming system |
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