New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging
MRI on fluorine-19 is an effective tool for imaging and monitoring phagocytic cells (macrophages, stem cells, etc.) This method is based on the visualization of perfluorocarbon (PFC) emulsions, which nanoparticles undergo endocytosis by macrophages in an organism. The liver and spleen are main place...
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| Veröffentlicht in: | Applied magnetic resonance 2020-12, Vol.51 (12), p.1625-1635 |
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| creator | Pavlova, Olga S. Gulyaev, Mikhail V. Anisimov, Nikolay V. Silachev, Denis N. Gervits, Lev L. Pirogov, Yury A. |
| description | MRI on fluorine-19 is an effective tool for imaging and monitoring phagocytic cells (macrophages, stem cells, etc.) This method is based on the visualization of perfluorocarbon (PFC) emulsions, which nanoparticles undergo endocytosis by macrophages in an organism. The liver and spleen are main places of emulsion accumulation, but not the only ones. The purpose of our study was to identify organs (besides the liver and spleen) that can accumulate PFC emulsions sufficiently for
19
F MRI. We studied the biodistribution of PFC emulsion in rats after two different methods of its introduction into an organism (intravenously and intraperitoneally). It was shown that PFC emulsions are accumulated by the thymus and the nearest lymph nodes in the sufficient amount (around 2% of the total intraperitoneally injected dose) to be visualized. It turned out that PFC emulsion is accumulated more in thymus after intraperitoneal injection in comparison with intravenous injection. This is due to the differences in the capture of emulsion by macrophages when it is initially injected into the bloodstream or the abdomen. |
| doi_str_mv | 10.1007/s00723-020-01242-w |
| format | Article |
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19
F MRI. We studied the biodistribution of PFC emulsion in rats after two different methods of its introduction into an organism (intravenously and intraperitoneally). It was shown that PFC emulsions are accumulated by the thymus and the nearest lymph nodes in the sufficient amount (around 2% of the total intraperitoneally injected dose) to be visualized. It turned out that PFC emulsion is accumulated more in thymus after intraperitoneal injection in comparison with intravenous injection. This is due to the differences in the capture of emulsion by macrophages when it is initially injected into the bloodstream or the abdomen.</description><identifier>ISSN: 0937-9347</identifier><identifier>EISSN: 1613-7507</identifier><identifier>DOI: 10.1007/s00723-020-01242-w</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Atoms and Molecules in Strong Fields ; Biodistribution ; Emulsions ; Fluorine ; Laboratory animals ; Laser Matter Interaction ; Liver ; Lymphatic system ; Macrophages ; Organic Chemistry ; Original Paper ; Perfluorocarbons ; Physical Chemistry ; Physics ; Physics and Astronomy ; Solid State Physics ; Spectroscopy/Spectrometry ; SPINUS2020 ; Spleen ; Stem cells ; Thymus gland</subject><ispartof>Applied magnetic resonance, 2020-12, Vol.51 (12), p.1625-1635</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-4b62213c73fc7af7f517d8bfe8409b5eb45ca259955213cb1b6ef1787e57399b3</citedby><cites>FETCH-LOGICAL-c319t-4b62213c73fc7af7f517d8bfe8409b5eb45ca259955213cb1b6ef1787e57399b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00723-020-01242-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917986161?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>Pavlova, Olga S.</creatorcontrib><creatorcontrib>Gulyaev, Mikhail V.</creatorcontrib><creatorcontrib>Anisimov, Nikolay V.</creatorcontrib><creatorcontrib>Silachev, Denis N.</creatorcontrib><creatorcontrib>Gervits, Lev L.</creatorcontrib><creatorcontrib>Pirogov, Yury A.</creatorcontrib><title>New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging</title><title>Applied magnetic resonance</title><addtitle>Appl Magn Reson</addtitle><description>MRI on fluorine-19 is an effective tool for imaging and monitoring phagocytic cells (macrophages, stem cells, etc.) This method is based on the visualization of perfluorocarbon (PFC) emulsions, which nanoparticles undergo endocytosis by macrophages in an organism. The liver and spleen are main places of emulsion accumulation, but not the only ones. The purpose of our study was to identify organs (besides the liver and spleen) that can accumulate PFC emulsions sufficiently for
19
F MRI. We studied the biodistribution of PFC emulsion in rats after two different methods of its introduction into an organism (intravenously and intraperitoneally). It was shown that PFC emulsions are accumulated by the thymus and the nearest lymph nodes in the sufficient amount (around 2% of the total intraperitoneally injected dose) to be visualized. It turned out that PFC emulsion is accumulated more in thymus after intraperitoneal injection in comparison with intravenous injection. This is due to the differences in the capture of emulsion by macrophages when it is initially injected into the bloodstream or the abdomen.</description><subject>Atoms and Molecules in Strong Fields</subject><subject>Biodistribution</subject><subject>Emulsions</subject><subject>Fluorine</subject><subject>Laboratory animals</subject><subject>Laser Matter Interaction</subject><subject>Liver</subject><subject>Lymphatic system</subject><subject>Macrophages</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Perfluorocarbons</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Solid State Physics</subject><subject>Spectroscopy/Spectrometry</subject><subject>SPINUS2020</subject><subject>Spleen</subject><subject>Stem cells</subject><subject>Thymus gland</subject><issn>0937-9347</issn><issn>1613-7507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kF9LwzAUxYMoOKdfwKeCz9H8aZrGtzk2HQwVnc8h6ZLZsTYzt2Xs29tawTdf7oVzzzkXfghdU3JLCZF30A3GMWEEE8pShg8naEQzyrEURJ6iEVFcYsVTeY4uALaEUJFTOULvz-6QTGDvigaS4JOHMqxLaGJp26YMdS-9uuh3bYihMNF20qxqd9DdICnr5M00cJ-sPo9VC8miMpuy3lyiM2924K5-9xh9zGer6RNevjwuppMlLjhVDU5txhjlheS-kMZLL6hc59a7PCXKCmdTURgmlBKit1lqM-epzKUTkitl-RjdDL37GL5aB43ehjbW3UvNFJUqz3oCY8QGVxEDQHRe72NZmXjUlOgenh7g6Q6e_oGnD12IDyHozPXGxb_qf1Lf6Z9yhA</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Pavlova, Olga S.</creator><creator>Gulyaev, Mikhail V.</creator><creator>Anisimov, Nikolay V.</creator><creator>Silachev, Denis N.</creator><creator>Gervits, Lev L.</creator><creator>Pirogov, Yury A.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20201201</creationdate><title>New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging</title><author>Pavlova, Olga S. ; Gulyaev, Mikhail V. ; Anisimov, Nikolay V. ; Silachev, Denis N. ; Gervits, Lev L. ; Pirogov, Yury A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-4b62213c73fc7af7f517d8bfe8409b5eb45ca259955213cb1b6ef1787e57399b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Atoms and Molecules in Strong Fields</topic><topic>Biodistribution</topic><topic>Emulsions</topic><topic>Fluorine</topic><topic>Laboratory animals</topic><topic>Laser Matter Interaction</topic><topic>Liver</topic><topic>Lymphatic system</topic><topic>Macrophages</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Perfluorocarbons</topic><topic>Physical Chemistry</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Solid State Physics</topic><topic>Spectroscopy/Spectrometry</topic><topic>SPINUS2020</topic><topic>Spleen</topic><topic>Stem cells</topic><topic>Thymus gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pavlova, Olga S.</creatorcontrib><creatorcontrib>Gulyaev, Mikhail V.</creatorcontrib><creatorcontrib>Anisimov, Nikolay V.</creatorcontrib><creatorcontrib>Silachev, Denis N.</creatorcontrib><creatorcontrib>Gervits, Lev L.</creatorcontrib><creatorcontrib>Pirogov, Yury A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Applied magnetic resonance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavlova, Olga S.</au><au>Gulyaev, Mikhail V.</au><au>Anisimov, Nikolay V.</au><au>Silachev, Denis N.</au><au>Gervits, Lev L.</au><au>Pirogov, Yury A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging</atitle><jtitle>Applied magnetic resonance</jtitle><stitle>Appl Magn Reson</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>51</volume><issue>12</issue><spage>1625</spage><epage>1635</epage><pages>1625-1635</pages><issn>0937-9347</issn><eissn>1613-7507</eissn><abstract>MRI on fluorine-19 is an effective tool for imaging and monitoring phagocytic cells (macrophages, stem cells, etc.) This method is based on the visualization of perfluorocarbon (PFC) emulsions, which nanoparticles undergo endocytosis by macrophages in an organism. 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19
F MRI. We studied the biodistribution of PFC emulsion in rats after two different methods of its introduction into an organism (intravenously and intraperitoneally). It was shown that PFC emulsions are accumulated by the thymus and the nearest lymph nodes in the sufficient amount (around 2% of the total intraperitoneally injected dose) to be visualized. It turned out that PFC emulsion is accumulated more in thymus after intraperitoneal injection in comparison with intravenous injection. This is due to the differences in the capture of emulsion by macrophages when it is initially injected into the bloodstream or the abdomen.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00723-020-01242-w</doi><tpages>11</tpages></addata></record> |
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| subjects | Atoms and Molecules in Strong Fields Biodistribution Emulsions Fluorine Laboratory animals Laser Matter Interaction Liver Lymphatic system Macrophages Organic Chemistry Original Paper Perfluorocarbons Physical Chemistry Physics Physics and Astronomy Solid State Physics Spectroscopy/Spectrometry SPINUS2020 Spleen Stem cells Thymus gland |
| title | New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging |
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