Development and optimization of ganciclovir-loaded carbopol topical gel by response surface methodology for enhanced skin permeation

Low permeability is one of the barriers to the bioavailability of drugs through the oral route. The purpose of the present study was to design and optimize a sustained release and highly permeable hydrogel formulation of ganciclovir (GCV) by using response surface methodology (RSM). Carbopol 934P wa...

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Veröffentlicht in:	Polymer bulletin (Berlin, Germany) Germany), 2023-11, Vol.80 (11), p.11817-11844
Hauptverfasser:	Siddique, Waqar, Zaman, Muhammad, Waheed, Sadaf, Sarfraz, Rai Muhammad, Bashir, Sajid, Minhas, Muhammad Usman, Farooq, Umar, Saeed, Asad
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Characterization and Evaluation of Materials Chemicals Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Design Design optimization Drug delivery systems Fourier transforms Hydrogels Irritation Laboratories Lag time Lipids Oleic acid Optimization Organic Chemistry Original Paper Parameters Permeation Physical Chemistry Polymer Sciences Propylene Response surface methodology Rheological properties Skin Soft and Granular Matter Solvents Sustained release Transdermal medication Viscosity
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