Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells
A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection...
Gespeichert in:
| Veröffentlicht in: | Applied magnetic resonance 2020-04, Vol.51 (4), p.375-387 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 387 |
|---|---|
| container_issue | 4 |
| container_start_page | 375 |
| container_title | Applied magnetic resonance |
| container_volume | 51 |
| creator | Andrianov, V. V. Yafarova, G. G. Pashkevich, S. G. Tokalchik, Y. P. Dosina, M. O. Zamaro, A. S. Bogodvid, T. Kh Iyudin, V. S. Bazan, L. V. Kulchitsky, V. A. Gainutdinov, Kh. L. |
| description | A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection of mesenchymal stem cells (MSCs). Brain ischemia was simulated by ligation at the level of bifurcation of the common carotid arteries. It was found a significant reduction of NO content in the olfactory bulb of the brain of rats on the 1st and 2nd days after modeling of ischemia. The level of NO production was also reduced on the 1st and 2nd days after ischemia with MSCs’ administration as compared to intact animals. It was not found the significant difference of the NO content in rats after ischemia with MSCs’ administration relative to ischemic rats. The copper content in the olfactory bulb of the rat, which corresponds to the level of superoxide dismutase 1 and 3, tended to increase after modeling ischemia and remained for 2 days. The MSCs’ administration was accompanied by a significant increase in copper content on the 1st day after modeling of ischemia and by decrease of its content on 2nd day after ischemia. The experiments showed that MSCs’ administration did not affect the intensity of NO production on the 1st and 2nd days after the modeling of brain ischemia, but was accompanied by an increase in the antioxidant protection of the nervous tissue 1 day after ischemia. |
| doi_str_mv | 10.1007/s00723-020-01195-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2917907483</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2917907483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-53a739d408b8eeea54352e452a0acb3c3b0e3d937b2ebc3ca571dbedd5e865073</originalsourceid><addsrcrecordid>eNp9kcFu3CAURVGVSp2k_YGukLp2-jAm2MuJ1aaRkoyUtGuE4TlD6oEpMFLmk_qXYcaRssuGJ3jnXqR7CfnK4JwByO-pHDWvoIYKGOtEBR_Igl0wXkkB8oQsoOOy6ngjP5HTlJ4AmGiZXJD__Vr7R0w0jDSvkd65HJ2hq2dnkWpvaR-2W4xl-Iw-U-eP2Goatckh7unlbhqO6nud6WXUBViOuShug8XJ-cfDbn5_yDH8nV2vfY7a66QnurQb510q9-yCP9C3mNCb9X5Ttg8ZN7THaUqfycdRTwm_vM4z8ufnj9_9r-pmdXXdL28qw1mXK8G15J1toB1aRNSi4aLGRtQatBm44QMgtyWNocbBcKOFZHZAawW2FyUrfka-zb7bGP7tMGX1FHbRly9V3THZgWxaXqh6pkwMKUUc1Ta6jY57xUAdKlFzJapUoo6VKCgiPotSgUvq8c36HdULd4iQpw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2917907483</pqid></control><display><type>article</type><title>Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central Student</source><source>ProQuest Central Korea</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Andrianov, V. V. ; Yafarova, G. G. ; Pashkevich, S. G. ; Tokalchik, Y. P. ; Dosina, M. O. ; Zamaro, A. S. ; Bogodvid, T. Kh ; Iyudin, V. S. ; Bazan, L. V. ; Kulchitsky, V. A. ; Gainutdinov, Kh. L.</creator><creatorcontrib>Andrianov, V. V. ; Yafarova, G. G. ; Pashkevich, S. G. ; Tokalchik, Y. P. ; Dosina, M. O. ; Zamaro, A. S. ; Bogodvid, T. Kh ; Iyudin, V. S. ; Bazan, L. V. ; Kulchitsky, V. A. ; Gainutdinov, Kh. L.</creatorcontrib><description>A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection of mesenchymal stem cells (MSCs). Brain ischemia was simulated by ligation at the level of bifurcation of the common carotid arteries. It was found a significant reduction of NO content in the olfactory bulb of the brain of rats on the 1st and 2nd days after modeling of ischemia. The level of NO production was also reduced on the 1st and 2nd days after ischemia with MSCs’ administration as compared to intact animals. It was not found the significant difference of the NO content in rats after ischemia with MSCs’ administration relative to ischemic rats. The copper content in the olfactory bulb of the rat, which corresponds to the level of superoxide dismutase 1 and 3, tended to increase after modeling ischemia and remained for 2 days. The MSCs’ administration was accompanied by a significant increase in copper content on the 1st day after modeling of ischemia and by decrease of its content on 2nd day after ischemia. The experiments showed that MSCs’ administration did not affect the intensity of NO production on the 1st and 2nd days after the modeling of brain ischemia, but was accompanied by an increase in the antioxidant protection of the nervous tissue 1 day after ischemia.</description><identifier>ISSN: 0937-9347</identifier><identifier>EISSN: 1613-7507</identifier><identifier>DOI: 10.1007/s00723-020-01195-0</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Atoms and Molecules in Strong Fields ; Brain ; Brain research ; Carotid arteries ; Copper ; Experiments ; Hypoxia ; Ischemia ; Ketamine ; Laboratory animals ; Laser Matter Interaction ; Modelling ; Nervous system ; Nitric oxide ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Physics ; Physics and Astronomy ; Physiology ; Solid State Physics ; Spectroscopy/Spectrometry ; Spectrum analysis ; Stem cells ; Stroke ; Superoxide dismutase</subject><ispartof>Applied magnetic resonance, 2020-04, Vol.51 (4), p.375-387</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-53a739d408b8eeea54352e452a0acb3c3b0e3d937b2ebc3ca571dbedd5e865073</citedby><cites>FETCH-LOGICAL-c319t-53a739d408b8eeea54352e452a0acb3c3b0e3d937b2ebc3ca571dbedd5e865073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00723-020-01195-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917907483?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,21388,21389,21390,23255,27923,27924,33529,33702,33743,34004,34313,41487,42556,43658,43786,43804,43952,44066,51318,64384,64388,72240</link.rule.ids></links><search><creatorcontrib>Andrianov, V. V.</creatorcontrib><creatorcontrib>Yafarova, G. G.</creatorcontrib><creatorcontrib>Pashkevich, S. G.</creatorcontrib><creatorcontrib>Tokalchik, Y. P.</creatorcontrib><creatorcontrib>Dosina, M. O.</creatorcontrib><creatorcontrib>Zamaro, A. S.</creatorcontrib><creatorcontrib>Bogodvid, T. Kh</creatorcontrib><creatorcontrib>Iyudin, V. S.</creatorcontrib><creatorcontrib>Bazan, L. V.</creatorcontrib><creatorcontrib>Kulchitsky, V. A.</creatorcontrib><creatorcontrib>Gainutdinov, Kh. L.</creatorcontrib><title>Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells</title><title>Applied magnetic resonance</title><addtitle>Appl Magn Reson</addtitle><description>A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection of mesenchymal stem cells (MSCs). Brain ischemia was simulated by ligation at the level of bifurcation of the common carotid arteries. It was found a significant reduction of NO content in the olfactory bulb of the brain of rats on the 1st and 2nd days after modeling of ischemia. The level of NO production was also reduced on the 1st and 2nd days after ischemia with MSCs’ administration as compared to intact animals. It was not found the significant difference of the NO content in rats after ischemia with MSCs’ administration relative to ischemic rats. The copper content in the olfactory bulb of the rat, which corresponds to the level of superoxide dismutase 1 and 3, tended to increase after modeling ischemia and remained for 2 days. The MSCs’ administration was accompanied by a significant increase in copper content on the 1st day after modeling of ischemia and by decrease of its content on 2nd day after ischemia. The experiments showed that MSCs’ administration did not affect the intensity of NO production on the 1st and 2nd days after the modeling of brain ischemia, but was accompanied by an increase in the antioxidant protection of the nervous tissue 1 day after ischemia.</description><subject>Atoms and Molecules in Strong Fields</subject><subject>Brain</subject><subject>Brain research</subject><subject>Carotid arteries</subject><subject>Copper</subject><subject>Experiments</subject><subject>Hypoxia</subject><subject>Ischemia</subject><subject>Ketamine</subject><subject>Laboratory animals</subject><subject>Laser Matter Interaction</subject><subject>Modelling</subject><subject>Nervous system</subject><subject>Nitric oxide</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Physiology</subject><subject>Solid State Physics</subject><subject>Spectroscopy/Spectrometry</subject><subject>Spectrum analysis</subject><subject>Stem cells</subject><subject>Stroke</subject><subject>Superoxide dismutase</subject><issn>0937-9347</issn><issn>1613-7507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFu3CAURVGVSp2k_YGukLp2-jAm2MuJ1aaRkoyUtGuE4TlD6oEpMFLmk_qXYcaRssuGJ3jnXqR7CfnK4JwByO-pHDWvoIYKGOtEBR_Igl0wXkkB8oQsoOOy6ngjP5HTlJ4AmGiZXJD__Vr7R0w0jDSvkd65HJ2hq2dnkWpvaR-2W4xl-Iw-U-eP2Goatckh7unlbhqO6nud6WXUBViOuShug8XJ-cfDbn5_yDH8nV2vfY7a66QnurQb510q9-yCP9C3mNCb9X5Ttg8ZN7THaUqfycdRTwm_vM4z8ufnj9_9r-pmdXXdL28qw1mXK8G15J1toB1aRNSi4aLGRtQatBm44QMgtyWNocbBcKOFZHZAawW2FyUrfka-zb7bGP7tMGX1FHbRly9V3THZgWxaXqh6pkwMKUUc1Ta6jY57xUAdKlFzJapUoo6VKCgiPotSgUvq8c36HdULd4iQpw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Andrianov, V. V.</creator><creator>Yafarova, G. G.</creator><creator>Pashkevich, S. G.</creator><creator>Tokalchik, Y. P.</creator><creator>Dosina, M. O.</creator><creator>Zamaro, A. S.</creator><creator>Bogodvid, T. Kh</creator><creator>Iyudin, V. S.</creator><creator>Bazan, L. V.</creator><creator>Kulchitsky, V. A.</creator><creator>Gainutdinov, Kh. L.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20200401</creationdate><title>Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells</title><author>Andrianov, V. V. ; Yafarova, G. G. ; Pashkevich, S. G. ; Tokalchik, Y. P. ; Dosina, M. O. ; Zamaro, A. S. ; Bogodvid, T. Kh ; Iyudin, V. S. ; Bazan, L. V. ; Kulchitsky, V. A. ; Gainutdinov, Kh. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-53a739d408b8eeea54352e452a0acb3c3b0e3d937b2ebc3ca571dbedd5e865073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Atoms and Molecules in Strong Fields</topic><topic>Brain</topic><topic>Brain research</topic><topic>Carotid arteries</topic><topic>Copper</topic><topic>Experiments</topic><topic>Hypoxia</topic><topic>Ischemia</topic><topic>Ketamine</topic><topic>Laboratory animals</topic><topic>Laser Matter Interaction</topic><topic>Modelling</topic><topic>Nervous system</topic><topic>Nitric oxide</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Physiology</topic><topic>Solid State Physics</topic><topic>Spectroscopy/Spectrometry</topic><topic>Spectrum analysis</topic><topic>Stem cells</topic><topic>Stroke</topic><topic>Superoxide dismutase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrianov, V. V.</creatorcontrib><creatorcontrib>Yafarova, G. G.</creatorcontrib><creatorcontrib>Pashkevich, S. G.</creatorcontrib><creatorcontrib>Tokalchik, Y. P.</creatorcontrib><creatorcontrib>Dosina, M. O.</creatorcontrib><creatorcontrib>Zamaro, A. S.</creatorcontrib><creatorcontrib>Bogodvid, T. Kh</creatorcontrib><creatorcontrib>Iyudin, V. S.</creatorcontrib><creatorcontrib>Bazan, L. V.</creatorcontrib><creatorcontrib>Kulchitsky, V. A.</creatorcontrib><creatorcontrib>Gainutdinov, Kh. L.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Applied magnetic resonance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrianov, V. V.</au><au>Yafarova, G. G.</au><au>Pashkevich, S. G.</au><au>Tokalchik, Y. P.</au><au>Dosina, M. O.</au><au>Zamaro, A. S.</au><au>Bogodvid, T. Kh</au><au>Iyudin, V. S.</au><au>Bazan, L. V.</au><au>Kulchitsky, V. A.</au><au>Gainutdinov, Kh. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells</atitle><jtitle>Applied magnetic resonance</jtitle><stitle>Appl Magn Reson</stitle><date>2020-04-01</date><risdate>2020</risdate><volume>51</volume><issue>4</issue><spage>375</spage><epage>387</epage><pages>375-387</pages><issn>0937-9347</issn><eissn>1613-7507</eissn><abstract>A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection of mesenchymal stem cells (MSCs). Brain ischemia was simulated by ligation at the level of bifurcation of the common carotid arteries. It was found a significant reduction of NO content in the olfactory bulb of the brain of rats on the 1st and 2nd days after modeling of ischemia. The level of NO production was also reduced on the 1st and 2nd days after ischemia with MSCs’ administration as compared to intact animals. It was not found the significant difference of the NO content in rats after ischemia with MSCs’ administration relative to ischemic rats. The copper content in the olfactory bulb of the rat, which corresponds to the level of superoxide dismutase 1 and 3, tended to increase after modeling ischemia and remained for 2 days. The MSCs’ administration was accompanied by a significant increase in copper content on the 1st day after modeling of ischemia and by decrease of its content on 2nd day after ischemia. The experiments showed that MSCs’ administration did not affect the intensity of NO production on the 1st and 2nd days after the modeling of brain ischemia, but was accompanied by an increase in the antioxidant protection of the nervous tissue 1 day after ischemia.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00723-020-01195-0</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-9347 |
| ispartof | Applied magnetic resonance, 2020-04, Vol.51 (4), p.375-387 |
| issn | 0937-9347 1613-7507 |
| language | eng |
| recordid | cdi_proquest_journals_2917907483 |
| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); ProQuest Central Student; ProQuest Central Korea; ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Atoms and Molecules in Strong Fields Brain Brain research Carotid arteries Copper Experiments Hypoxia Ischemia Ketamine Laboratory animals Laser Matter Interaction Modelling Nervous system Nitric oxide Organic Chemistry Original Paper Physical Chemistry Physics Physics and Astronomy Physiology Solid State Physics Spectroscopy/Spectrometry Spectrum analysis Stem cells Stroke Superoxide dismutase |
| title | Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T05%3A50%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20of%20the%20Nitric%20Oxide%20and%20Copper%20Content%20in%20the%20Olfactory%20Bulbs%20of%20Rat%20Brain%20After%20Modeling%20of%20Brain%20Stroke%20and%20Intranasal%20Administration%20of%20Mesenchymal%20Stem%20Cells&rft.jtitle=Applied%20magnetic%20resonance&rft.au=Andrianov,%20V.%20V.&rft.date=2020-04-01&rft.volume=51&rft.issue=4&rft.spage=375&rft.epage=387&rft.pages=375-387&rft.issn=0937-9347&rft.eissn=1613-7507&rft_id=info:doi/10.1007/s00723-020-01195-0&rft_dat=%3Cproquest_cross%3E2917907483%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2917907483&rft_id=info:pmid/&rfr_iscdi=true |