Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release
Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hy...
Gespeichert in:
| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2015-11, Vol.72 (11), p.2739-2756 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2756 |
|---|---|
| container_issue | 11 |
| container_start_page | 2739 |
| container_title | Polymer bulletin (Berlin, Germany) |
| container_volume | 72 |
| creator | El-Arnaouty, M. B. Abdel Ghaffar, A. M. Aboulfotouh, Maysara E. Taher, N. H. Taha, Ahmed A. |
| description | Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4–7.5 was investigated. It is found that the swelling behavior of Poly(BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates. |
| doi_str_mv | 10.1007/s00289-015-1433-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2917873839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2917873839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-1d9cc046fc234d962067ecc265747760cd6da009905cf40446008b3f4a2c2ea83</originalsourceid><addsrcrecordid>eNp1kM1KAzEURoMoWKsP4C7gRhdjbzJpZmYpxT8oKKLrkCZ3OlOmk5qki_ENfGtTRnDl6t5LzvcFDiGXDG4ZQDELALysMmDzjIk8z9gRmaRFZlyI6phMgBWQQZlXp-QshA2kW0o2Id9v2rY6tq6nYehjg6ENVPeWmkZ7bSL69mt8djV9dd1wvdrHoaNbjI02fuh0xNm4bFuLN9S4XaK2KWdoM1jv1tiNjQ3utG_7RPTRu65DS63fr6nHDnXAc3JS6y7gxe-cko-H-_fFU7Z8eXxe3C0zI3geM2YrY0DI2vBc2EpykAUaw-W8EEUhwVhpNUBVwdzUAoSQAOUqr4XmhqMu8ym5Gnt33n3uMUS1cXvfpy8Vr1hRFnmylCg2Usa7EDzWaufbrfaDYqAOxtVoXCXj6mBcsZThYyYktl-j_2v-P_QDyiWGkQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2917873839</pqid></control><display><type>article</type><title>Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release</title><source>Springer Nature - Complete Springer Journals</source><source>ProQuest Central</source><creator>El-Arnaouty, M. B. ; Abdel Ghaffar, A. M. ; Aboulfotouh, Maysara E. ; Taher, N. H. ; Taha, Ahmed A.</creator><creatorcontrib>El-Arnaouty, M. B. ; Abdel Ghaffar, A. M. ; Aboulfotouh, Maysara E. ; Taher, N. H. ; Taha, Ahmed A.</creatorcontrib><description>Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4–7.5 was investigated. It is found that the swelling behavior of Poly(BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates.</description><identifier>ISSN: 0170-0839</identifier><identifier>EISSN: 1436-2449</identifier><identifier>DOI: 10.1007/s00289-015-1433-1</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acrylamide ; Anticoagulants ; Aqueous solutions ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Copolymerization ; Drug dosages ; Equilibrium ; Gelation ; Heparin ; Hydrogels ; Organic Chemistry ; Original Paper ; Physical Chemistry ; Polymer Sciences ; Polymers ; Radiation ; Radiation dosage ; Radiation effects ; Soft and Granular Matter ; Swelling</subject><ispartof>Polymer bulletin (Berlin, Germany), 2015-11, Vol.72 (11), p.2739-2756</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-1d9cc046fc234d962067ecc265747760cd6da009905cf40446008b3f4a2c2ea83</citedby><cites>FETCH-LOGICAL-c423t-1d9cc046fc234d962067ecc265747760cd6da009905cf40446008b3f4a2c2ea83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00289-015-1433-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917873839?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,41464,42533,43781,51294</link.rule.ids></links><search><creatorcontrib>El-Arnaouty, M. B.</creatorcontrib><creatorcontrib>Abdel Ghaffar, A. M.</creatorcontrib><creatorcontrib>Aboulfotouh, Maysara E.</creatorcontrib><creatorcontrib>Taher, N. H.</creatorcontrib><creatorcontrib>Taha, Ahmed A.</creatorcontrib><title>Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release</title><title>Polymer bulletin (Berlin, Germany)</title><addtitle>Polym. Bull</addtitle><description>Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4–7.5 was investigated. It is found that the swelling behavior of Poly(BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates.</description><subject>Acrylamide</subject><subject>Anticoagulants</subject><subject>Aqueous solutions</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Copolymerization</subject><subject>Drug dosages</subject><subject>Equilibrium</subject><subject>Gelation</subject><subject>Heparin</subject><subject>Hydrogels</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Radiation</subject><subject>Radiation dosage</subject><subject>Radiation effects</subject><subject>Soft and Granular Matter</subject><subject>Swelling</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kM1KAzEURoMoWKsP4C7gRhdjbzJpZmYpxT8oKKLrkCZ3OlOmk5qki_ENfGtTRnDl6t5LzvcFDiGXDG4ZQDELALysMmDzjIk8z9gRmaRFZlyI6phMgBWQQZlXp-QshA2kW0o2Id9v2rY6tq6nYehjg6ENVPeWmkZ7bSL69mt8djV9dd1wvdrHoaNbjI02fuh0xNm4bFuLN9S4XaK2KWdoM1jv1tiNjQ3utG_7RPTRu65DS63fr6nHDnXAc3JS6y7gxe-cko-H-_fFU7Z8eXxe3C0zI3geM2YrY0DI2vBc2EpykAUaw-W8EEUhwVhpNUBVwdzUAoSQAOUqr4XmhqMu8ym5Gnt33n3uMUS1cXvfpy8Vr1hRFnmylCg2Usa7EDzWaufbrfaDYqAOxtVoXCXj6mBcsZThYyYktl-j_2v-P_QDyiWGkQ</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>El-Arnaouty, M. B.</creator><creator>Abdel Ghaffar, A. M.</creator><creator>Aboulfotouh, Maysara E.</creator><creator>Taher, N. H.</creator><creator>Taha, Ahmed A.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20151101</creationdate><title>Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release</title><author>El-Arnaouty, M. B. ; Abdel Ghaffar, A. M. ; Aboulfotouh, Maysara E. ; Taher, N. H. ; Taha, Ahmed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-1d9cc046fc234d962067ecc265747760cd6da009905cf40446008b3f4a2c2ea83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acrylamide</topic><topic>Anticoagulants</topic><topic>Aqueous solutions</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Copolymerization</topic><topic>Drug dosages</topic><topic>Equilibrium</topic><topic>Gelation</topic><topic>Heparin</topic><topic>Hydrogels</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Radiation</topic><topic>Radiation dosage</topic><topic>Radiation effects</topic><topic>Soft and Granular Matter</topic><topic>Swelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Arnaouty, M. B.</creatorcontrib><creatorcontrib>Abdel Ghaffar, A. M.</creatorcontrib><creatorcontrib>Aboulfotouh, Maysara E.</creatorcontrib><creatorcontrib>Taher, N. H.</creatorcontrib><creatorcontrib>Taha, Ahmed A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Arnaouty, M. B.</au><au>Abdel Ghaffar, A. M.</au><au>Aboulfotouh, Maysara E.</au><au>Taher, N. H.</au><au>Taha, Ahmed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2015-11-01</date><risdate>2015</risdate><volume>72</volume><issue>11</issue><spage>2739</spage><epage>2756</epage><pages>2739-2756</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4–7.5 was investigated. It is found that the swelling behavior of Poly(BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-015-1433-1</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0170-0839 |
| ispartof | Polymer bulletin (Berlin, Germany), 2015-11, Vol.72 (11), p.2739-2756 |
| issn | 0170-0839 1436-2449 |
| language | eng |
| recordid | cdi_proquest_journals_2917873839 |
| source | Springer Nature - Complete Springer Journals; ProQuest Central |
| subjects | Acrylamide Anticoagulants Aqueous solutions Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Copolymerization Drug dosages Equilibrium Gelation Heparin Hydrogels Organic Chemistry Original Paper Physical Chemistry Polymer Sciences Polymers Radiation Radiation dosage Radiation effects Soft and Granular Matter Swelling |
| title | Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T16%3A42%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Radiation%20synthesis%20and%20characterization%20of%20Poly(butyl%20methacrylate/acrylamide)%20copolymeric%20hydrogels%20and%20heparin%20controlled%20drug%20release&rft.jtitle=Polymer%20bulletin%20(Berlin,%20Germany)&rft.au=El-Arnaouty,%20M.%20B.&rft.date=2015-11-01&rft.volume=72&rft.issue=11&rft.spage=2739&rft.epage=2756&rft.pages=2739-2756&rft.issn=0170-0839&rft.eissn=1436-2449&rft_id=info:doi/10.1007/s00289-015-1433-1&rft_dat=%3Cproquest_cross%3E2917873839%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2917873839&rft_id=info:pmid/&rfr_iscdi=true |