Fabrication of hesperidin self-micro-emulsifying nutraceutical delivery system embedded in sodium alginate beads to elicit gastric stability
Poor bioavailability of hesperidin (HES) due to its gastric instability and low aqueous solubility limits its clinical application. The objective of presented work was to incorporate self-microemulsifying drug delivery system of HES (SMEDDS-HES) into alginate beads. The alginate beads were character...
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| Veröffentlicht in: | Polymer bulletin (Berlin, Germany) Germany), 2022, Vol.79 (1), p.605-626 |
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| creator | Dangre, Pankaj V. Dusad, Poorva P. Singh, Alok D. Surana, Sanjay J. Chaturvedi, Kaushalendra K. Chalikwar, Shailesh S. |
| description | Poor bioavailability of hesperidin (HES) due to its gastric instability and low aqueous solubility limits its clinical application. The objective of presented work was to incorporate self-microemulsifying drug delivery system of HES (SMEDDS-HES) into alginate beads. The alginate beads were characterized for their size and morphology by using motic microscopy and scanning electron microscopy. The selected beads formulation (BF 7) revealed particle size (1.3 ± 0.117 mm), entrapment efficiency (87.4 ± 2.2%), circularity (0.9987), aspect ratio (0.9950), and swelling index (81.75 ± 2.14%). The encapsulation of HES in beads was assured by Fourier transform infrared spectroscopy study. The in vitro drug release kinetic of beads was performed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The results revealed negligible release of HES (3.52 ± 0.8%) from beads in SGF after 2 h, and in SIF (after 8 h), the beads showed burst release (72.52 ± 3.5%) of HES. Antidiabetic and histopathological studies on experimental rat revealed promising hypoglycemic activity of beads which sought for its ability to protect HES in the stomach. The shelf life of optimized bead formulation was estimated 1079 days suggesting excellent stability of HES after encapsulation. Finally, developed beads formulation was considered a promising approach in oral delivery of HES. |
| doi_str_mv | 10.1007/s00289-020-03507-7 |
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The objective of presented work was to incorporate self-microemulsifying drug delivery system of HES (SMEDDS-HES) into alginate beads. The alginate beads were characterized for their size and morphology by using motic microscopy and scanning electron microscopy. The selected beads formulation (BF 7) revealed particle size (1.3 ± 0.117 mm), entrapment efficiency (87.4 ± 2.2%), circularity (0.9987), aspect ratio (0.9950), and swelling index (81.75 ± 2.14%). The encapsulation of HES in beads was assured by Fourier transform infrared spectroscopy study. The in vitro drug release kinetic of beads was performed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The results revealed negligible release of HES (3.52 ± 0.8%) from beads in SGF after 2 h, and in SIF (after 8 h), the beads showed burst release (72.52 ± 3.5%) of HES. Antidiabetic and histopathological studies on experimental rat revealed promising hypoglycemic activity of beads which sought for its ability to protect HES in the stomach. The shelf life of optimized bead formulation was estimated 1079 days suggesting excellent stability of HES after encapsulation. 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Bull</addtitle><description>Poor bioavailability of hesperidin (HES) due to its gastric instability and low aqueous solubility limits its clinical application. The objective of presented work was to incorporate self-microemulsifying drug delivery system of HES (SMEDDS-HES) into alginate beads. The alginate beads were characterized for their size and morphology by using motic microscopy and scanning electron microscopy. The selected beads formulation (BF 7) revealed particle size (1.3 ± 0.117 mm), entrapment efficiency (87.4 ± 2.2%), circularity (0.9987), aspect ratio (0.9950), and swelling index (81.75 ± 2.14%). The encapsulation of HES in beads was assured by Fourier transform infrared spectroscopy study. The in vitro drug release kinetic of beads was performed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The results revealed negligible release of HES (3.52 ± 0.8%) from beads in SGF after 2 h, and in SIF (after 8 h), the beads showed burst release (72.52 ± 3.5%) of HES. Antidiabetic and histopathological studies on experimental rat revealed promising hypoglycemic activity of beads which sought for its ability to protect HES in the stomach. The shelf life of optimized bead formulation was estimated 1079 days suggesting excellent stability of HES after encapsulation. Finally, developed beads formulation was considered a promising approach in oral delivery of HES.</description><subject>Antidiabetics</subject><subject>Aspect ratio</subject><subject>Bioavailability</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Drug delivery systems</subject><subject>Encapsulation</subject><subject>Entrapment</subject><subject>Fourier transforms</subject><subject>Functional foods & nutraceuticals</subject><subject>Microscopy</subject><subject>Morphology</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Particle size</subject><subject>Permeability</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Shelf life</subject><subject>Sodium</subject><subject>Sodium alginate</subject><subject>Soft and Granular Matter</subject><subject>Stability</subject><subject>Surfactants</subject><issn>0170-0839</issn><issn>1436-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMtKBDEQRYMoOD5-wFXAdTSP7k56KeILBDe6DumkMmbox5ikhf4HP9qMI7hzVRR1zy04CF0wesUoldeJUq5aQjklVNRUEnmAVqwSDeFV1R6iFWWynJRoj9FJShta9qZhK_R1b7oYrMlhGvHk8TukLcTgwogT9J4MwcaJwDD3KfgljGs8zjkaC3MuVI8d9OET4oLTkjIMGIYOnAOHdwWTC_OATb8Oo8mAOzAu4TzhwtiQ8dqkXH7jlE0X-pCXM3TkTZ_g_Heeorf7u9fbR_L88vB0e_NMrGBtJpJRoNB4pXinGuAgLO-cdaypfA3euVr4CpiUjVLKKA7Odq2grlbAOitqcYou973bOH3MkLLeTHMcy0vNWyaVFLLapfg-VQykFMHrbQyDiYtmVO-s6711XazrH-taFkjsoVTC4xriX_U_1DecJIlQ</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Dangre, Pankaj V.</creator><creator>Dusad, Poorva P.</creator><creator>Singh, Alok D.</creator><creator>Surana, Sanjay J.</creator><creator>Chaturvedi, Kaushalendra K.</creator><creator>Chalikwar, Shailesh S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><orcidid>https://orcid.org/0000-0003-1550-1310</orcidid></search><sort><creationdate>2022</creationdate><title>Fabrication of hesperidin self-micro-emulsifying nutraceutical delivery system embedded in sodium alginate beads to elicit gastric stability</title><author>Dangre, Pankaj V. ; Dusad, Poorva P. ; Singh, Alok D. ; Surana, Sanjay J. ; Chaturvedi, Kaushalendra K. ; Chalikwar, Shailesh S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-710e0e6f882b86e2e3c2bdcd164f5efdd53f4e1776888a82edcb930d58e1bc353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antidiabetics</topic><topic>Aspect ratio</topic><topic>Bioavailability</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Drug delivery systems</topic><topic>Encapsulation</topic><topic>Entrapment</topic><topic>Fourier transforms</topic><topic>Functional foods & nutraceuticals</topic><topic>Microscopy</topic><topic>Morphology</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Particle size</topic><topic>Permeability</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Shelf life</topic><topic>Sodium</topic><topic>Sodium alginate</topic><topic>Soft and Granular Matter</topic><topic>Stability</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dangre, Pankaj V.</creatorcontrib><creatorcontrib>Dusad, Poorva P.</creatorcontrib><creatorcontrib>Singh, Alok D.</creatorcontrib><creatorcontrib>Surana, Sanjay J.</creatorcontrib><creatorcontrib>Chaturvedi, Kaushalendra K.</creatorcontrib><creatorcontrib>Chalikwar, Shailesh S.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Polymer bulletin (Berlin, Germany)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dangre, Pankaj V.</au><au>Dusad, Poorva P.</au><au>Singh, Alok D.</au><au>Surana, Sanjay J.</au><au>Chaturvedi, Kaushalendra K.</au><au>Chalikwar, Shailesh S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of hesperidin self-micro-emulsifying nutraceutical delivery system embedded in sodium alginate beads to elicit gastric stability</atitle><jtitle>Polymer bulletin (Berlin, Germany)</jtitle><stitle>Polym. Bull</stitle><date>2022</date><risdate>2022</risdate><volume>79</volume><issue>1</issue><spage>605</spage><epage>626</epage><pages>605-626</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><abstract>Poor bioavailability of hesperidin (HES) due to its gastric instability and low aqueous solubility limits its clinical application. The objective of presented work was to incorporate self-microemulsifying drug delivery system of HES (SMEDDS-HES) into alginate beads. The alginate beads were characterized for their size and morphology by using motic microscopy and scanning electron microscopy. The selected beads formulation (BF 7) revealed particle size (1.3 ± 0.117 mm), entrapment efficiency (87.4 ± 2.2%), circularity (0.9987), aspect ratio (0.9950), and swelling index (81.75 ± 2.14%). The encapsulation of HES in beads was assured by Fourier transform infrared spectroscopy study. The in vitro drug release kinetic of beads was performed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The results revealed negligible release of HES (3.52 ± 0.8%) from beads in SGF after 2 h, and in SIF (after 8 h), the beads showed burst release (72.52 ± 3.5%) of HES. Antidiabetic and histopathological studies on experimental rat revealed promising hypoglycemic activity of beads which sought for its ability to protect HES in the stomach. The shelf life of optimized bead formulation was estimated 1079 days suggesting excellent stability of HES after encapsulation. Finally, developed beads formulation was considered a promising approach in oral delivery of HES.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-020-03507-7</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0003-1550-1310</orcidid></addata></record> |
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| subjects | Antidiabetics Aspect ratio Bioavailability Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Drug delivery systems Encapsulation Entrapment Fourier transforms Functional foods & nutraceuticals Microscopy Morphology Organic Chemistry Original Paper Particle size Permeability Physical Chemistry Polymer Sciences Shelf life Sodium Sodium alginate Soft and Granular Matter Stability Surfactants |
| title | Fabrication of hesperidin self-micro-emulsifying nutraceutical delivery system embedded in sodium alginate beads to elicit gastric stability |
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